The present study elucidates the protective efficacy of red ginseng polysaccharide (RGP) against septic-associated acute lung injury (ALI), a critical condition exacerbated by oxidative stress and endoplasmic reticulum (ER) stress. Utilizing lipopolysaccharide (LPS)-induced mouse cellular models, we assessed pathology through histological staining, scoring, wet-to-dry ratios along with inflammatory cytokine levels. Cell viability apoptosis were quantified using cell counting kit-8 TUNEL...

Background Disulfidptosis and ferroptosis are forms of programmed cell death that may be associated with the pathogenesis periodontitis. Our study developed periodontitis-associated biomarkers combining disulfidptosis ferroptosis, which provides a new perspective on Methods Firstly, we obtained periodontitis dataset from public databases found disulfidptosis- ferroptosis-related differentially expressed transcripts based transcript sets. After that, tissue for were using three machine...

Abstract The telomeric protein TRF2, involving in and extratelomeric DNA damage response, has been previously reported to facilitate multidrug resistance (MDR) gastric cancer cells by interfering ATM-dependent response induced anticancer drugs. Rap1 is the TRF2-interacting shelterin complex. Complex formation between TRF2 essential for their function telomere end protection. Here we focus on effects of Both expression were upregulated SGC7901 its MDR variant SGC7901/VCR after etoposide...

The two commonly used diagnostic methods for taurodontism are susceptible to aging changes, mastication wear and other factors. Therefore, this study proposed an improved method taurodontism, compared it with the previous as a supplement diagnosis.

Background Radiomics has been extensively applied in predicting Ki‐67 breast cancer (BC). However, this is often confined to the exploration of a single sequence, without considering varying sensitivity and specificity among different sequences. Purpose To develop nomogram based on dual‐sequence MRI derived radiomic features combined with clinical characteristics for assessing expression BC. Study Type Retrospective. Population 227 females (average age, 51 years) 233 lesions pathologically...

Purpose: Although brain metastasis (BM) from gastric cancer (GC) is relatively uncommon, its incidence has been increasing owing to advancements in treatment modalities. Unfortunately, patients diagnosed with BM have poor life expectancy. Our study aims establish a predictive model for advanced patients, thus enabling the timely diagnosis of metastasis. Patients and Methods: The clinicopathological features cohort which included 40 GC metastasis, 32 whom First Affiliated Hospital Nanchang...

BACKGROUND The combination of magnetic compression anastomosis (MCA) and endoscopy has been used to treat biliary stricture after liver transplantation. However, its use for the treatment complex obstruction major abdominal trauma not reported. This case report describes successful MCA resulting from trauma. CASE SUMMARY A 23-year-old man underwent surgery (repair rupture, right half colon resection, ileostomy) following a car accident one year ago. drainage tube, positioned at Winslow...

Objective: To investigate the clinicopathological features, molecular genetics, treatment and prognosis of Burkitt-like lymphoma with 11q aberration (BLL-11q). Methods: Six cases BLL-11q diagnosed at First Affiliated Hospital Zhengzhou University, from January 2016 to 2020 were reviewed analyzed using hematoxylin-eosin staining, immunohistochemistry, EBER in situ hybridization fluorescence hybridization. Clinical information including follow-up data was collected analyzed. Results: The...

Objective: To investigate the clinicopathological features of pulmonary epithelioid hemangioendothelioma (PEHE). Methods: Eighteen cases PEHE were collected from August 2011 to December 2018 at First Affiliated Hospital Zhengzhou University. All retrospectively studied by hematoxylin and eosin staining immunohistochemistry (IHC). The reviewed; status CAMTA1 TFE3 gene was analyzed patients' outcome followed up. Results: Of 18 cases, there 11 males 7 females with a male female ratio 1.6 1.0....

Objective: To investigate the expression of microRNA-140-5p (miR-140-5p) in esophageal squamous cell carcinoma (ESCC) and its role proliferation invasion ESCC. Methods: Real-time quantitative PCR (qPCR) was used to detect levels miR-140-5p ESCC tissues cells. Negative control mimic were transfected into Eca109 KYSE70 CCK-8 kit Transwell assay employed examine changes ability after transfection, respectively. The dual-luciferase reporter assess interaction with Glut1. Western blot utilized...

Objective: To study clinical features of rheumatoid arthritis (RA) patients with peripheral neuropathy (PN). Methods: The data 46 RA PN in the First Affiliated Hospital Zhengzhou University from August 2012 to 2019 were retrospectively analyzed, including manifestations, laboratory and imaging results, previous treatment, treatment outcome. other 92 without at same period selected as controls. Results: In PN, male female ratio was 1∶2.1 an average age (59.1±11.8) years. course 102.0...

OBJECTIVE To investigate the biologic effects of Bcl-XL antisense oligodeoxynucleotide (ASODN) transfected into cultured esophageal carcinoma cells and human xenograft in nude mice. METHODS Cationic liposome-mediated ASODN was used to transfect cells. RT-PCR, Western blot, MTT assay, flow cytometry in-situ apoptosis detection (TUNEL detection) were systematically study biological vitro vivo. RESULTS assay showed that proliferation group decreased significantly as compared with control (P <...

To investigate how Chinese rheumatologists treated patients with rheumatoid arthritis (RA). We performed a survey on the choices of first-line and second-line anti-RA therapies, prescription methotrexate glucocorticoids, assessment disease activity frequencies follow-up at Asia Pacific League Associations for Rheumatology meeting 2016 in Shanghai. The majority (85.1%) preferred as treatment. As alternative agents, 71.0% chose leflunomide or sulfasalazine. If was not tolerable, only 8.6%...

Objective: To evaluate the medium-and long-term outcomes of cardiac assist devices after coronary artery bypass grafting (CABG) in patients with left ventricular dysfunction. Methods: From January 2012 to May 2018, a total 127 low ejection fraction (LVEF) value (≤40%) undergoing CABG Department Cardiovascular Surgery First Affiliated Hospital Zhengzhou University were selected. Meanwhile, another 2 454 cases LVEF>55% also enrolled as controls. Clinical data intra-aortic balloon pump (IABP)...

Objective: To investigate the clinicopathological features and molecular genetics of cyclin D1-negative mantle cell lymphoma (MCL). Methods: The CyclinD1-negative MCL diagnosed between January 2016 July 2021 at First Affiliated Hospital Zhengzhou University were analyzed using immunohistochemistry fluorescence in situ hybridization. Clinical information was collected analyzed. Results: A total five Cyclin cases from all 212 patients (5/212, 2.4%)were included. There three male two female...

Objective: To study the clinicopathologic features and MYD88 L265P mutation status of intravascular large B cell lymphoma (IVLBCL). Methods: Fourteen cases IVLBCLs were diagnosed from March 2014 to December 2019 at First Affiliated Hospital Zhengzhou University. The prognosis analyzed. Epstein-Barr virus encoded RNAs detected using in situ hybridization Sanger sequencing, respectively. follow-up data obtained by telephone interview. Results: There 6 males 8 females with a median age 62 years...