Abstract Sea‐land breeze (SLB) is particularly important in coastal regions and can affect weather conditions air quality. However, previous research on SLB has predominantly focused specific locations, with varying methodologies used to identify days (SLBDs), leading a limited understanding of long‐term trends across extensive areas. Here, unified method for gridded reanalysis dataset SLBDs proposed the first time, trend, influencing factors, effects pollutant recirculation over China are...

Abstract This study investigates the connection between key sea surface temperature (SST) anomalies in North Pacific during boreal spring (February-April, FMA) and subsequent South China Sea (SCS) summer monsoon (SCSSM) onset. The SST anomalies, similar to meridional mode (PMM), referred as PMM + mode, is defined new impact factor on SCSSM It found that (February-March-April, has a significant positive correlation with May onset date, which weakly affected by ENSO previous winter. A strong...

Benign central airway stenosis poses a significant challenge to respiratory and thoracic surgeons due the high recurrence rate associated with current treatment methods, causing severe breathing difficulties potentially life-threatening complications. This article aims investigate therapeutic efficacy prospects of using coblation in management benign adults. Moreover, pathogenesis was deeply explored provide better guidance for future clinical treatments.

To investigate the clinicopathological characteristics and genetic mutations of SMARCA4-deficient lung adenocarcinoma.

Lymphomatoid papulosis (LyP) with DUSP22 rearrangement is an uncommon subtype of lymphomatoid featured histologically by two distinct patterns epidermotropic cells, weakly CD30+ small- to medium-sized T-cells and a dermal infiltrate strongly medium- large-sized T-cells. detected more frequently in anaplastic large cell lymphoma (ALCL) than LyP. Primary cutaneous (pcALCL) cases can also show similar biphasic CD30 staining pattern. LyP has indolent clinical course pcALCL likely regress without...

Abstract Unlike prior researches focusing on interannual or interdecadal changes of the Northwest Pacific subtropical high (NWPSH), this paper emphasizes in relationship between May‐June and July‐August NWPSH. The correlation coefficients them are 0.66 (passing 99.9% confidence level) 0.12 during 1979–2002 2003–2023. Therefore, NWPSH has a strong connection with East Asian precipitation 1979–2002, but not variations due to ENSO. During eastern‐type ENSO winter, having longer durations, can...

To investigate the diagnostic features of pulmonary sclerosing pneumocytoma (PSP) in needle biopsy specimens so as to improve preoperative accuracy and prevent misdiagnoses.

The underlying regulating mechanisms of miR-105-5p/PTEN in colon cancer (CC) progression are still unknown. MiR-105-5p and PTEN expressions were determined using RT-PCR. protein levels examined by western blot. Also, the contents inflammatory cytokines (IL-1β, TNF-α, IL-6) measured via ELISA. An inflammation model was constructed LPS. NF-κB p65 expression assessed immunofluorescence assay. A xenograft tumor BALB/c nude mice. functions miR-105-5p investigated establishing a model, H&E...

Abstract Compared to interannual and interdecadal variations, inadequate attention has been given intraseasonal changes in the summer northwest Pacific subtropical high (NWPSH). During 1981–2005, north Indian Ocean (NIO) NWPSH exhibit significant relationships from June August, while influences of Boreal Summer Intraseasonal Oscillation 1 (BSISO1) August differ its impacts July, resulting a correlation between August. The models capture NIO's roles but underestimate BSISO1's influences,...

Objective: To investigate the role of microRNA-139-5p (miR-139-5p) in occurrence and development esophageal squamous cell carcinoma (ESCC) its effects on proliferation invasion ESCC cells molecular mechanisms. Methods: Seventy-five cases tissues paired normal were obtained from thoracic surgery First Affiliated Hospital Zhengzhou University February 2017 to March 2018. Experiment was divided into two group: (n=75) (n=75).GEO datasets real-time quantitative PCR (qRT-PCR) used detect...

Objective: To investigate the clinicopathological features of pulmonary epithelioid hemangioendothelioma (PEHE). Methods: Eighteen cases PEHE were collected from August 2011 to December 2018 at First Affiliated Hospital Zhengzhou University. All retrospectively studied by hematoxylin and eosin staining immunohistochemistry (IHC). The reviewed; status CAMTA1 TFE3 gene was analyzed patients' outcome followed up. Results: Of 18 cases, there 11 males 7 females with a male female ratio 1.6 1.0....

Objective: To investigate the clinicopathologic features and prognosis of mediastinal T lymphoblastic lymphoma/leukemia (T-LBL/ALL). Methods: Sixty-one patients with T-LBL/ALL diagnosed at First Affiliated Hospital Zhengzhou University from August 1, 2011 to December 31, 2018 were enrolled. Their clinical, pathological, imaging retrospectively analyzed. Results: Of 61 T-LBL/ALL, 46 male 15 female, a female ratio approximately 3∶1, aged 5 71 years (median 24 years, average 24.5 years)....

Objective: To investigate the expression of microRNA-140-5p (miR-140-5p) in esophageal squamous cell carcinoma (ESCC) and its role proliferation invasion ESCC. Methods: Real-time quantitative PCR (qPCR) was used to detect levels miR-140-5p ESCC tissues cells. Negative control mimic were transfected into Eca109 KYSE70 CCK-8 kit Transwell assay employed examine changes ability after transfection, respectively. The dual-luciferase reporter assess interaction with Glut1. Western blot utilized...

目的： 探讨胸腺类癌的临床病理特征，并对其预后及影响因素进行分析。 方法： 收集郑州大学第一附属医院2011年8月至2020年10月诊断的25例胸腺类癌，分析其临床病理特征及预后，并对1例多发性内分泌腺瘤病1型（MEN1）患者及其子的外周血进行基因遗传学分析。 结果：...

Rationale: Birt-Hogg-Dubé (BHD) syndrome is a rare autosomal recessive genetic disorder caused mainly by mutations in the tumor suppressor FLCN gene. Tumors are frequently benign and develop skin, lungs, kidney, other organs, leading to variety of phenotypes that make early diagnoses BHD challenging. Patient concerns: A 51-year-old female was admitted Shanghai Seventh People Hospital due chest congestion dyspnea had persisted for 3 years aggravated 1 month. She been diagnosed with...

患儿 男，9岁，因“血压升高13个月”就诊于首都儿科研究所，病初最高血压184/122 mmHg（1 mmHg=0.133 kPa），口服3种降压药物，血压仍在2级以上，腹部增强CT发现右肾中极楔形灌注减低区，肾动脉造影见右肾上前段的一支叶间动脉狭窄，行肾分支动脉栓塞术，用微球及弹簧圈栓塞成功，无并发症发生。术后6 d患儿血肾素浓度恢复正常，心脏超声左心房内径恢复正常，左心室质量指数降至正常，肾功能正常。术后6个月随访，降压药物调整为2种，血压控制在2级以下，分肾功能正常。.

目的： 探讨原发于消化道CIC重排肉瘤的临床病理学特征。 方法： 回顾性分析2例原发于消化道的CIC重排肉瘤，包括病理学形态、免疫表型、遗传学特征及生存预后，并复习相关文献。 结果： 2例均为男性，年龄分别为44岁和54岁；肿瘤分别位于小肠和直肠，直径8.0 cm和9.0 cm。低倍镜下肿瘤呈分叶状或结节状，可见纤维性间隔和大片坏死。高倍镜下瘤细胞小至中等大，圆形或卵圆形，核形不规则，可见核分裂象，部分可见核仁。免疫组织化学显示2例均弥漫表达WT1，灶性表达CD99，Ki-67阳性指数分别为50%、70%。采用断裂分离探针荧光原位杂交（FISH）检测发现2例均有CIC基因断裂。2例分别于术后半个月、6个月发生远处转移，转移部位包括肺、腹腔及盆腔；1例于术后1个月死亡，1例存活。 结论： 发生在消化道的CIC重排肉瘤，组织病理学形态与尤因肉瘤较相似，免疫组织化学常表达WT1和CD99，确诊需借助FISH检测，患者预后较差。.

报道1例椎管内室管膜瘤转移至心脏的病例。患者男，65岁。入院后发现右心房占位性病变，以“黏液瘤”行肿块切除。镜下观察：肿瘤细胞排列呈片状，可见室管膜腔隙，肿瘤细胞立方形或多角形，细胞核卵圆形，胞质丰富嗜酸性。患者3年后再次入院，CT发现全身多处静脉内瘤栓及骨质多发转移。行髂骨穿刺活检见大量血管周围假菊形团。两次标本免疫组织化学均胶质纤维酸性蛋白、S-100蛋白阳性，上皮细胞膜抗原核旁点状阳性，N-MYC基因未见扩增。患者第二次入院穿刺确诊后行化疗1个周期，出院后4个月死亡。.

Abstract Purpose The aim was to investigate the safety and efficacy of 125 I brachytherapy as consolidative local therapy for patients with synchonous oligometastatic non-small cell lung cancer (sOM-NSCLC) without progression after first-line chemotherapy plus PD-1 inhibitors treatment percutaneous. Materials Methods We retrospective analyzed 38 (31 male [81.6%], 7 women [18.4%], median age 66 years,range:[47-77 years] ) sOM-NSCLC epidermal growth factor receptor (EGFR) or anaplastic...