A5061672936- Neuroblastoma Research and Treatments
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Histone Deacetylase Inhibitors Research
- Signaling Pathways in Disease
- RNA Research and Splicing
- Cell death mechanisms and regulation
- Peptidase Inhibition and Analysis
- Proteoglycans and glycosaminoglycans research
- Cancer Research and Treatments
- Neonatal Respiratory Health Research
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- Testicular diseases and treatments
- Ubiquitin and proteasome pathways
- Glycosylation and Glycoproteins Research
- Helicobacter pylori-related gastroenterology studies
- Urological Disorders and Treatments
- Mechanisms of cancer metastasis
- Curcumin's Biomedical Applications
- Esophageal Cancer Research and Treatment
- Pediatric Urology and Nephrology Studies
- Cancer-related gene regulation
Huazhong University of Science and Technology
2016-2025
Union Hospital
2016-2025
Union Hospital
2014-2024
Wuhan Union Hospital
2005-2023
Zhengzhou Children's Hospital
2021
Zhengzhou University
2021
Center for Genomic Science
2015
Xi'an Jiaotong University
2012
Academy of Military Medical Sciences
2010
University of Oxford
2008-2009
Argonaute 2 (AGO2), the core component of microRNA (miRNA)-induced silencing complex, plays a compelling role in tumorigenesis and aggressiveness. However, mechanisms regulating functions AGO2 cancer still remain elusive. Herein, we indentify one intronic circular RNA (circRNA) generated from gene (circAGO2) as novel regulator AGO2-miRNA complexes progression. CircAGO2 is up-regulated gastric cancer, colon prostate neuroblastoma, associated with poor prognosis patients. promotes growth,...
Circular RNAs (circRNAs), a subclass of non-coding RNAs, play essential roles in tumorigenesis and aggressiveness. Our previous study has identified that circAGO2 drives gastric cancer progression through activating human antigen R (HuR), protein stabilizing AU-rich element-containing mRNAs. However, the functions underlying mechanisms circRNAs derived from HuR remain elusive.CircRNAs were detected by real-time quantitative RT-PCR validated Sanger sequencing. Biotin-labeled RNA pull-down,...
Circular RNAs (circRNA), a subclass of noncoding RNA characterized by covalently closed continuous loops, play emerging roles in tumorigenesis and aggressiveness. However, the functions underlying mechanisms circRNA regulating Wnt/β-catenin signaling cancer progression remain elusive. Here, we screen cis-acting generated β-catenin (CTNNB1)/transcription factor 7-like 2 genes identify one intronic derived from CTNNB1 (circ-CTNNB1) as novel driver progression. Circ-CTNNB1 was predominantly...
Abstract Matrix metalloproteinase (MMP)-14 is the only membrane-anchored MMP that plays a critical role in tumor metastasis and angiogenesis. However, mechanisms underlying MMP-14 expression tumors still remain largely unknown. In this study, immunostaining was identified 29/42 neuroblastoma tissues, which correlated with clinicopathologic features shorter patients' survival. subtotal 20 cases, microRNA 9 (miR-9) downregulated inversely expression. Bioinformatics analysis revealed putative...
Recent evidence shows that altered microRNA-9 (miR-9) expression is implicated in the progression of gastric cancer. However, exact roles and underlying mechanisms miR-9 proliferation, invasion metastasis cancer still remain unknown. In this study, was found to be down-regulated inversely correlated with cyclin D1 v-ets erythroblastosis virus E26 oncogene homolog 1 (Ets1) tissues cell lines. Bioinformatics analysis revealed putative binding sites 3′-untranslated regions (3′-UTR) Ets1 mRNA....
Article11 November 2019Open Access Source DataTransparent process Therapeutic targeting of circ-CUX1/EWSR1/MAZ axis inhibits glycolysis and neuroblastoma progression Huanhuan Li Department Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University Science Technology, Wuhan, Hubei Province, China Search for more papers by this author Feng Yang Anpei Hu Xiaojing Wang Clinical Center Human Genomic Research, Erhu Fang Yajun Chen Pathology, Dan Huajie Song Jianqun Yanhua Guo...
Long noncoding RNAs (lncRNA) play essential roles in tumor progression. However, the functions of lncRNAs tumorigenesis and aggressiveness neuroblastoma still remain to be determined. Here, we report identification lncRNA pancEts-1 as a novel driver progression by using public microarray dataset. LncRNA promoted growth, invasion, metastasis cells vitro vivo Mechanistically, bound hnRNPK facilitate its physical interaction with β-catenin, whereas stabilized β-catenin inhibiting...
Macroautophagy/autophagy is a conserved cellular process associated with tumorigenesis and aggressiveness, while mechanisms regulating expression of autophagic machinery genes in cancers still remain elusive. Herein, we identified E2F4 (E2F transcription factor 4) as novel transcriptional activator cytoprotective autophagy crucial for zinc homeostasis cancer cells. Gain- loss-of-function studies showed that promoted cell cycle-dependent manner, resulting facilitated degradation MT...
Heparanase (HPSE) is the endogenous endoglycosidase that degrades heparan sulfate proteoglycans and promotes tumor growth, invasion, metastasis angiogenesis. Our previous studies have shown HPSE highly expressed in neuroblastoma (NB), most common extracranial solid childhood. However, underlying regulatory mechanisms remain largely unknown. In this study, we identified one binding site of microRNA-558 (miR-558) within promoter. NB tissues cell lines, miR-558 was up-regulated positively...
Cheng C, Lu X, Wang G, Zheng L, Shu Zhu S, Liu K, Wu Tong Q. Expression of SATB1 and heparanase in gastric cancer its relationship to clinicopathologic features. APMIS 2010; 118: 855–63. The purpose this study was investigate the expression special AT‐rich binding protein 1 (SATB1) human as well factors. Specimens from 102 patients who underwent radical gastrectomy between 2000 2002 were studied by immunohistochemistry for expression. positively expressed 48.0% 51.0% cases, respectively....
Abstract Recent evidence shows that v-ets erythroblastosis virus E26 oncogene homolog 1 (Ets1) is implicated in tumor development and progression. However, the clinical potentials underlying mechanisms of Ets1 gastric cancer progression metastasis remain largely unknown. In this study, immunostaining was identified 56 84 (66.7%) tissues, which correlated with invasion metastasis. specimens cell lines, miRNA-145 (miR-145) downregulated inversely expression. Bioinformatics analysis luciferase...
Abstract Recent evidence shows the emerging roles of promoter-targeting endogenous microRNAs (miRNAs) in regulating gene transcription. However, miRNAs affecting transcription matrix metalloproteinase 14 ( MMP-14 ) gastric cancer remain unknown. Herein, through integrative mining public datasets, we identified adjacent targeting sites Yin Yang 1 (YY1) and miRNA-584-3p (miR-584-3p) within promoter. We demonstrated that YY1 directly targeted promoter to facilitate its expression cells. In...
Neuroblastoma (NB) is the most common extracranial tumor in childhood. Recent studies have implicated emerging roles of long noncoding RNAs (lncRNAs) tumorigenesis and aggressiveness. However, functions targets risk-associated lncRNAs NB progression still remain to be determined. Herein, through mining public microarray datasets, we identify lncRNA forkhead box D3 antisense RNA 1 (FOXD3-AS1) as an independent prognostic marker for favorable outcome patients. FOXD3-AS1 downregulated tissues...
Aerobic glycolysis is a hallmark of metabolic reprogramming that contributes to tumor progression. However, the mechanisms regulating expression glycolytic genes in neuroblastoma (NB), most common extracranial solid childhood, still remain elusive.Crucial transcriptional regulators and their downstream were identified by integrative analysis publicly available profiling dataset. In vitro vivo assays undertaken explore biological effects underlying NB cells. Survival was performed using...
Abstract Background Metabolic reprogramming sustains tumorigenesis and aggressiveness of neuroblastoma (NB), the most common extracranial malignancy in childhood, while underlying mechanisms therapeutic approaches still remain elusive. Methods Circular RNAs (circRNAs) were validated by Sanger sequencing. Co-immunoprecipitation, mass spectrometry, chromatin immunoprecipitation (ChIP) sequencing, RNA sequencing assays applied to explore protein interaction target genes. Gene expression...
Objective Given the high prevalence of non-alcoholic fatty liver disease (NAFLD) and its potential to progress fibrosis, it is crucial identify presence NAFLD in patients guide their subsequent management. However, current availability non-invasive biomarkers for remains limited. Therefore, further investigation needed develop NAFLD. Methods A retrospective analysis was conducted on 11,883 admitted Healthcare Center, Union Hospital, Tongji Medical College, Huazhong University Science...
Abstract Background A series of studies have demonstrated the emerging involvement transfer RNA (tRNA) processing during progression tumours. Nevertheless, roles and regulating mechanisms tRNA genes in neuroblastoma (NB), prevalent malignant tumour outside brain children, are yet unknown. Methods Analysis multi‐omics results was conducted to identify crucial regulators downstream genes. Co‐immunoprecipitation mass spectrometry methods were utilised measure interaction between proteins. The...
The transcription factor forkhead box D3 (FOXD3) plays a crucial role in the development of neural crest cells. However, function and underlying mechanisms FOXD3 progression neuroblastoma (NB), an embryonal tumor that is derived from crest, still remain largely unknown. Here, we report important oncosuppressor NB tumorigenicity aggressiveness. We found was down-regulated tissues cell lines. Patients with high expression have greater survival probability. Over-expression or knockdown...