A5014877023- Gastrointestinal Tumor Research and Treatment
- Lymphoma Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Renal Diseases and Glomerulopathies
- Metastasis and carcinoma case studies
- Cancer Immunotherapy and Biomarkers
- Liver Disease Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Immune Cell Function and Interaction
- Vascular Tumors and Angiosarcomas
- Meta-analysis and systematic reviews
Guangzhou Medical University
2024
First Affiliated Hospital of Zhengzhou University
2021-2024
Southern University of Science and Technology
2024
Background. In this research, programmed cell death protein 1 (PD-1) inhibitors, including toripalimab, sintilimab, and camrelizumab, were evaluated for the treatment of non-small-cell lung cancer (NSCLC). Methods. This retrospective research was conducted on patients with locally advanced NSCLC receiving various PD-1 inhibitors between April 2019 March 2023. Results. total, ORR DCR 167 included in 40.72% (68/167) 92.81% (155/167), respectively, while statistical median PFS 13.90 months (95%...
To investigate the clinicopathological, immunophenotypic and molecular genetic characteristics, differential diagnosis of NTRK-rearranged spindle cell neoplasms (NTRK-RSCNs) in gastrointestinal tract.
Objective: To investigate the clinicopathological features, molecular genetics, treatment and prognosis of Burkitt-like lymphoma with 11q aberration (BLL-11q). Methods: Six cases BLL-11q diagnosed at First Affiliated Hospital Zhengzhou University, from January 2016 to 2020 were reviewed analyzed using hematoxylin-eosin staining, immunohistochemistry, EBER in situ hybridization fluorescence hybridization. Clinical information including follow-up data was collected analyzed. Results: The...
目的： 探讨血管免疫母细胞性T细胞淋巴瘤（AITL）累及胃肠道的临床病理学特点、诊断及预后。 方法： 收集郑州大学第一附属医院2021年9月诊断的1例肠道活检的AITL，复习临床特点，行HE染色、免疫组织化学、EB病毒编码的RNA（EBER）原位杂交、T细胞受体（TCR）基因重排（BIOMED2法）及二代测序检测1 166个基因，并复习总结文献中报道的AITL累及胃肠道的特征。 结果： 患者女，53岁，肠镜示回盲部至直肠多发结节状、息肉样隆起；HE示典型AITL的形态，肿瘤主要浸润黏膜固有层，局部侵及黏膜下层，未见固有腺体侵犯及黏膜表面溃疡；免疫组织化学：肿瘤细胞表达T系标志物（CD3、CD4、CD5）及滤泡辅助T细胞标志物（PD-1及CXCL13），CD21示滤泡树突状细胞网增生紊乱，Ki-67阳性指数约40%；EBER原位杂交见散在细胞阳性；二代测序检测发现3组融合基因：EIF4E3-FOXP1、RP11-434C1.1-ETV6、RP11-380O24.1-SRGAP3。随访2个月，患者化疗1个疗程后因肠出血死亡。 结论：...