A5038003086- Advancements in Battery Materials
- Advanced Battery Materials and Technologies
- Plant-based Medicinal Research
- Hepatitis B Virus Studies
- Advanced Battery Technologies Research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Advanced Biosensing Techniques and Applications
- Cancer-related gene regulation
- RNA Interference and Gene Delivery
- Fibroblast Growth Factor Research
- Hepatitis C virus research
- Kruppel-like factors research
- Immune Response and Inflammation
- Neurological Disease Mechanisms and Treatments
- Mass Spectrometry Techniques and Applications
- Advanced Proteomics Techniques and Applications
- Immunotherapy and Immune Responses
- Drug-Induced Hepatotoxicity and Protection
- Alkaloids: synthesis and pharmacology
- RNA regulation and disease
- Monoclonal and Polyclonal Antibodies Research
- Tracheal and airway disorders
- Immune cells in cancer
- Advanced biosensing and bioanalysis techniques
Jiujiang University
2024-2025
Southern Medical University
2021-2025
Nanfang Hospital
2021-2025
Shenyang Medical College
2025
China University of Geosciences
2022-2025
First Affiliated Hospital of Harbin Medical University
2025
First Affiliated Hospital of Guangzhou Medical University
2023-2024
State Key Laboratory of Respiratory Disease
2023-2024
Guangzhou Medical University
2023-2024
Guangzhou Experimental Station
2024
Immunohistochemistry (IHC) combined with fluorescence microscopy provides an important and widely used tool for researchers pathologists to image multiple biomarkers in tissue specimens. However, multiplex IHC using standard is generally limited 3–5 different biomarkers, hyperspectral or multispectral methods 8. We report the development of a new technology based on novel photocleavable mass-tags (PC-MTs) facile antibody labeling, which enables highly multiplexed MALDI mass spectrometric...
Vascular dementia (VD) is a prevalent cognitive disorder among the elderly. Its pathological mechanism encompasses neuronal damage, synaptic dysfunction, vascular abnormalities, neuroinflammation, and oxidative stress, others. In recent years, extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) have garnered significant attention as an emerging therapeutic strategy. Current research indicates that MSC-derived (MSC-EVs) play pivotal role in both diagnosis treatment of VD....
Composite polymer electrolytes (CPEs) with high security and mechanical flexibility are needed for all-solid-state lithium-metal batteries (LMBs). However, their practical application is hindered by the increasing demand high-power high-areal-energy-density storage solutions. Herein, a high-powered CPE relying on poly(ε-caprolactone) (PCL) as matrix developed. The binding energy of Li+-PCL predicted to be −130.163 kcal·mol–1 via density functional theory calculations, which implies...
Abstract Background Genome-wide changes in DNA methylation are an epigenetic phenomenon that can lead to the development of disease. The study global utilizes technology requires both expensive equipment and highly specialized skill sets. Methods We have designed developed assay, CpG lobal, which is easy-to-use, does not utilize PCR, radioactivity equipment. lobal methyl-sensitive restriction enzymes, HRP Neutravidin detect biotinylated nucleotides incorporated end-fill reaction a...
Characterization of nonpolar lipids is crucial due to their essential biological functions and ability exist in various isomeric forms. In this study, we introduce the N-H aziridination method target carbon-carbon double bonds (C═C bonds) sterol lipids. The resulting fragments are readily dissociated upon collision-induced dissociation, generating specific fragment ions for C═C bond position determination fingerprint backbone characterization. This significantly enhances lipid ionization...
Hypoxia contributes to cancer progression through various molecular mechanisms and hepatocellular carcinoma (HCC) is one of the most hypoxic malignancies. Hypoxia-inducible gene domain protein-1a (HIGD1A) typically induced via epigenetic regulation promotes tumor cell survival during hypoxia. However, role HIGD1A in HCC remains unknown. expression was determined 24 pairs human samples para-tumorous tissues. Loss-of-function experiments were conducted both vivo vitro explore proliferation...
The Hypoxia inducible gene domain family member 2A (HIGD2A) protein is indispensable for the assembly of mitochondrial respiratory supercomplex, which has been implicated in cell proliferation and survival under hypoxic conditions. Because liver a naturally low oxygen microenvironment, role HIGD2A development hepatocellular carcinoma (HCC) remains largely unknown.Gene expression data clinical information were obtained from multiple public databases. A lentivirus-mediated knockdown approach...
ABSTRACT Sepsis is an aggressive and life-threatening systemic inflammatory response with a high mortality. Inflammation coagulation play crucial roles in the pathogenesis of sepsis mutually promoting manner. Unlike other single-target molecular therapies that have no obvious effects on clinical sepsis, bone marrow stromal cell (BMSC) therapy offers broader spectrum activities ranging from immune inflammation suppression to tissue regeneration. In this report, we demonstrate BMSC injection...
A multifunctional interlayer with Mg, LiF, and Li 3 N has been in situ constructed on the surface of LATP via a facile drop-casting method, which restrains decomposition improves interfacial stability during cycling.
Colorectal cancer (CRC) is the second leading cause of deaths in US and Western world. Despite increased screening advances treatment, mortality rate (ca. 50,000/year) high national health-care burden for CRC are likely to remain unless an effective non-invasive test instituted a large segment population. Blood-based protein biomarkers hold great promise early disease diagnosis personalized medicine; yet robust reproducible multiplexing platforms methodologies have lagged behind their...