A5100402026- Microtubule and mitosis dynamics
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Photosynthetic Processes and Mechanisms
- Axon Guidance and Neuronal Signaling
- Pluripotent Stem Cells Research
- Cellular transport and secretion
- RNA modifications and cancer
- Nanoplatforms for cancer theranostics
- DNA Repair Mechanisms
- Autophagy in Disease and Therapy
- Cellular Mechanics and Interactions
- Metabolism, Diabetes, and Cancer
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Genetic factors in colorectal cancer
- Pancreatic function and diabetes
- Hippo pathway signaling and YAP/TAZ
- Alzheimer's disease research and treatments
- Nuclear Receptors and Signaling
- Cancer Research and Treatments
- Plant nutrient uptake and metabolism
- Genomics and Chromatin Dynamics
Ruijin Hospital
2024
Shanghai Jiao Tong University
2024
Southern Medical University
2021-2023
Nanfang Hospital
2023
Tongji University
2022
First Affiliated Hospital of Anhui Medical University
2022
Anhui Medical University
2022
Community Link
2022
University of Hong Kong
2012-2019
Shenzhen Institutes of Advanced Technology
2019
NudE and NudEL are related proteins that interact with cytoplasmic dynein LIS1. Their functional relationship involvement in LIS1 regulation not completely understood. We find each localize to mitotic kinetochores before dynein, dynactin, ZW10, exhibit additional temporal spatial differences distribution from the motor protein. Inhibition of caused metaphase arrest misoriented chromosomes defective microtubule attachment. Dynein dynactin were both displaced by injection an anti-NudE/NudEL...
The Hypoxia inducible gene domain family member 2A (HIGD2A) protein is indispensable for the assembly of mitochondrial respiratory supercomplex, which has been implicated in cell proliferation and survival under hypoxic conditions. Because liver a naturally low oxygen microenvironment, role HIGD2A development hepatocellular carcinoma (HCC) remains largely unknown.Gene expression data clinical information were obtained from multiple public databases. A lentivirus-mediated knockdown approach...
Aurora kinases are overexpressed in many cancers and targets for anticancer drugs. The yeast homolog of B kinase, IPL1, was found to be a ploidy-specific lethality gene. Given that polyploidization is common feature cancers, we hypothesized also sensitizes mammalian cells inhibition kinases. Using two models apparent diploid vs. tetraploid cell lines (one based on the hepatocellular carcinoma line Hep3B another untransformed mouse fibroblasts), were more sensitive than their counterparts....
Understanding how glucose transporter isoform 4 (GLUT4) redistributes to the plasma membrane during insulin stimulation is a major goal of research. GLUT4 molecules normally reside in numerous intracellular compartments, including specialized storage vesicles and early/recycling endosomes. It unclear these diverse compartments respond deliver membrane. For example, do they fuse with each other first or remain as separate different trafficking characteristics? Our recent live cell imaging...
Lung cancer (LC) is one of the most common malignancies worldwide with low 5-year survival rate. The mechanism spindle and kinetochore-associated complex subunit 3 (SKA3) in LC tumorgenesis remains largely unclear. expression SKA3 cells was detected by quantitative PCR. Cell proliferation, migration cell cycle were evaluated functional assays including 5-ethynyl-2'-deoxyuridine, wound healing, transwell flow cytometry analysis. Bioinformatics analysis, chromatin immunoprecipitation,...
FYCO1, an autophagy adaptor, plays essential role in the trafficking toward plus-end of microtubules and fusion autophagosomes. Autophagic dysfunction is involved numerous disease states, including cancers. Previous studies have implicated FYCO1 as one critical genes adenoma to carcinoma transition, but biological function mechanism carcinogenesis remain unclear. This study aims elucidate up- downregulation mediating tumor effects HeLa cells. Functionally, promotes cellular migration,...
Centromere protein L (CENPL) is involved in the mitotic process of eukaryotic cells and development various types cancer. However, its role hepatocellular carcinoma (HCC) remains unclear. This study aimed to investigate expression clinical significance CENPL HCC, explore involvement regulating HCC cell proliferation, apoptosis, cycle, glycolysis both vivo vitro. was analyzed normal liver tissues using The Cancer Genome Atlas, Gene Expression Omnibus mining, real-time quantitative polymerase...
Background: Progressive axon degeneration is a common pathological feature of neurodegenerative diseases. Cdc42 member the Rho GTPase family that participates in axonogenesis. GSK-3β serine/threonine kinase highly implicated neuronal development and neurodegeneration. This study aimed to examine whether cdc42 promotes axonogenesis by regulating activity. Methods: Hippocampal neurons were isolated from neonatal Sprague-Dawley rats transfected with designated plasmid vectors alter activities...