A5088215267- Reproductive Health and Technologies
- Multiple Sclerosis Research Studies
- Assisted Reproductive Technology and Twin Pregnancy
- Ovarian function and disorders
- Reproductive Biology and Fertility
- Genetic Mapping and Diversity in Plants and Animals
- Systemic Lupus Erythematosus Research
- Acute Lymphoblastic Leukemia research
- HIV-related health complications and treatments
- Hemoglobinopathies and Related Disorders
- Prenatal Screening and Diagnostics
- Global Maternal and Child Health
- Child Nutrition and Water Access
- Interprofessional Education and Collaboration
- Hemophilia Treatment and Research
- Parasites and Host Interactions
- Folate and B Vitamins Research
- RNA regulation and disease
- Chronic Myeloid Leukemia Treatments
- Mycobacterium research and diagnosis
- Genetic and phenotypic traits in livestock
- Mental Health and Patient Involvement
- Ultrasound and Hyperthermia Applications
- Peripheral Neuropathies and Disorders
- HIV/AIDS drug development and treatment
Ono Pharmaceutical (United States)
2014-2025
Counties Manukau District Health Board
2016-2024
Pfizer (United States)
2023-2024
Merck (Germany)
2014-2023
Laerdal (Norway)
2023
Research & Development Institute
2023
Merck & Co., Inc., Rahway, NJ, USA (United States)
2021
Merck Serono (Italy)
2014-2020
Middlemore Hospital
2017
University at Buffalo, State University of New York
2015
Genome-wide association studies for complex diseases will produce genotypes on hundreds of thousands single nucleotide polymorphisms (SNPs). A logical first approach to dealing with massive numbers SNPs is use some test screen the SNPs, retaining only those that meet criterion further study. For example, can be ranked by p-value, and lowest p-values retained. When have large interaction effects but small marginal in a population, they are unlikely retained when univariate tests used...
Abstract There has been a great interest and few successes in the identification of complex disease susceptibility genes recent years. Association studies, where large number single‐nucleotide polymorphisms (SNPs) are typed sample cases controls to determine which associated with specific disease, provide powerful approach for gene mapping. Genes those studies may contain numbers SNPs that classical statistical methods cannot handle simultaneously without requiring prohibitively sizes. By...
Multiple sclerosis (MS) is a debilitating autoimmune disease of the CNS, which characterized by demyelination and axonal injury frequently preceded demyelinating event called clinically isolated syndrome (CIS). Despite importance B cells autoantibodies in MS pathology, their target specificities remain largely unknown. For an agnostic comprehensive evaluation MS, we developed employed what believe to be novel autoantigen discovery technology, Antigenome Platform. This Platform...
Summary. BDDrFVIII is a B‐domain deleted recombinant factor VIII (rFVIII) product for haemophilia A. Manufacture uniquely includes purification chromatography by synthetic‐affinity ligand rather than murine‐based monoclonal antibody, as well an albumin‐free cell culture process. was studied in 204 patients, including 62 subjects <16 years old, two studies. A double‐blind, randomized, pharmacokinetic (PK) crossover study, utilizing central laboratory assay (one‐stage (OS)) both drug...
The redesign of the physical workplace according to activity-based working (ABW) principles has potential influence employee health and outcomes. This natural experiment examined changes in accelerometer-derived activity, self-reported eating behaviours, productivity, satisfaction before (March November 2014) six nine months after moving an ABW compared a comparison (n = 146 at baseline (56% ABW, aged 40.1 ± 8.5 years, 72% female). Interviews were also conducted with 21 participants....
Background and Objectives: Oral cladribine tablet (CladT) therapy is efficacious for relapsing multiple sclerosis (MS). However, the mechanisms by which exerts benefit in MS remain unclear, particularly regarding its effects on compartmentalized inflammation within cerebrospinal fluid (CSF). Methods: Transcriptional profiles along with T B lymphocyte receptor repertoires from CSF blood were obtained single cell sequencing methods a site participating phase IV clinical trial investigating...
A number of studies have begun to investigate the characteristics cocaine abusers who are admitted outpatient treatment programs. One study has published success rates for such treatment. review this literature indicates that much what is known based on clinical experience with may be nonrepresentative samples upper-middle socioeconomic status Caucasians. More systematic and more representative needed; current attempts address these issues by sampling 81 clients a comprehensive program in...
This prospective, Phase IV, multicenter, observational registry of assisted reproductive technology clinics in the USA studied outcomes first cycles using thawed/warmed cryopreserved (by slow-freezing/vitrification) oocytes (autologous or donor). Patients were followed up through implantation, clinical pregnancy, and birth outcomes. The main outcome measure was live rate (LBR), defined as ratio births to minus number embryos for each cycle, averaged over all thawing cycles. Clinical...
Abstract Random Forest is a prediction technique based on growing trees bootstrap samples of data, in conjunction with random selection explanatory variables to define the best split at each node. In case quantitative outcome, tree predictor takes numerical value. We applied first replicate Genetic Analysis Workshop 13 simulated data set, sibling pairs as our units analysis and identity by descent (IBD) selected loci variables. With knowledge true model, we performed two sets analyses three...
The Health & Quality Safety Commission New Zealand commissioned Ko Awatea, an innovation and improvement centre, to deliver a co-design programme nine teams of healthcare providers. was part Partners in Care, broader developed 2012 support enable patient engagement participation across the health disability sector. In current received training, guidance mentorship Experience Based Design (EBD) methodology through one day masterclass, seven WebEx sessions, coaching calls, email completion...
The purpose of this mixed methods, cross-sectional patient survey was to characterize experience, explore the frequency and reasons for infertility treatment discontinuation return treatments. Participants were recruited from United States support groups. had received or receiving ovulation induction (OI) with without intrauterine insemination (IUI), subsequent in vitro fertilization (IVF), IVF no other previous treatment. Live birth achieved by 62% participants. Compared participants...
<h3>Objective:</h3> To characterise and investigate the functional consequences of a novel <i>TNFRSF1A</i> splice site mutation causing tumour necrosis factor receptor associated periodic syndrome (TRAPS) in 16-year-old male patient his mother. <h3>Methods:</h3> Mutational DNA screening was performed Western blotting used to analyse protein expression levels TNFR1. A multiplex bead immunoassay quantify serum range cytokines, an ELISA-based transcription assay measure nuclear (NF)-κB...
•Data on infertility prevalence and treatment in US women with MS are lacking•Exploratory analysis of administrative claims data assessed impact fertility•Women had lower live birth rates than those without MS•Women were less likely to receive oral or injectable treatment•Live following similar irrespective BackgroundReal-world regarding (LBRs) multiple sclerosis (MS) lacking. This study compared LBRs, diagnoses, treatments MS.MethodsUsing a retrospective database, patients 18–55 years...
Praziquantel (PZQ) is currently the only recommended drug for infection and disease caused by schistosome species that infects humans; however, current tablet formulation not suitable pre-school age children mainly due to its bitterness large size. We assessed palatability of two new orally disintegrating (ODT) formulations PZQ.This randomized, single-blind, crossover, swill-and-spit study (NCT02315352) was carried out at a single school in Tanzania aged 6-11 years old, with or without...
Cladribine tablets and fingolimod have similar marketing authorisations in Europe for the treatment of patients with highly active relapsing multiple sclerosis (HA-RMS). In absence direct head-to-head studies, real-world data are important to assess comparative effectiveness these oral disease-modifying therapies (DMTs). The primary objective present study was compare relapse rates between who received either cladribine or fingolimod.This multicentre retrospective conducted United Kingdom...
Background This pilot study investigated changes in remyelinating and demyelinating activity normal appearing brain tissue (NABT) lesions, by using voxel-wise magnetization transfer ratio (VW-MTR), patients with relapsing–remitting multiple sclerosis (RRMS) receiving interferon beta-1a 44 mcg subcutaneously (IFN β-1a SC) three times weekly versus healthy controls (HCs) (NCT01085318). Methods Increasing (suggestive of remyelination) decreasing demyelination) VW-MTR NABT T2, T1 gadolinium...
Objective: To understand the prevalence of HIV-associated wasting (HIVAW) in United States. Design: Medical and pharmacy claims study using IBM MarketScan Commercial, Medicare Supplemental Medicaid Databases. Methods: Study period: July 2012–September 2018 (first HIV diagnosis claim = index date). People with (PWH) were excluded if they aged less than 18 years, had any malignancy or 6 months enrollment data pre post-HIV date. HIVAW was defined by proxy for weight loss–related diagnoses,...
Patients with multiple sclerosis (MS) often receive long-term injectable therapy, and difficulties associated self-injection can affect treatment adherence efficacy.The objective of this study was to evaluate an investigational, ready-to-use, single-use autoinjector for subcutaneous (sc) interferon beta-1a (IFNβ-1a).In multicenter, open-label, single-arm study, patients relapsing MS who were receiving IFNβ-1a sc 44 μg three times weekly ≥ 12 weeks continued therapy using a completed user...
Objectives: To demonstrate, using human factors engineering (HFE), that a redesigned, pre-filled, ready-to-use, pre-asembled follitropin alfa pen can be used to administer prescribed doses safely and accurately.Methods: A failure modes effects analysis identified hazards harms potentially caused by use errors; risk-control measures were implemented ensure acceptable device risk management. Participants women with infertility, their significant others, fertility nurse (FN) professionals....
To assess potential roles of effector cells and immunologic markers in demyelinating CNS lesion formation, their modulation by interferon β-1a (IFN-β-1a).Twenty-three patients with relapsing-remitting multiple sclerosis (RRMS) received IFN-β-1a for 6 months. Immunologic marker results were correlated brain MRI volumes, volumes normal-appearing tissue (NABT) decreasing or increasing voxel-wise magnetization transfer ratio (VW-MTR), suggestive demyelination remyelination, respectively.Baseline...
Brain volume atrophy is observed in relapsing–remitting multiple sclerosis (RRMS). changes were evaluated 23 patients with RRMS treated interferon β-1a 44 μg given subcutaneously (SC) three times a week (tiw) and 15 healthy controls. Percentages of whole brain tissue-specific change measured from baseline (0 months) to 3 months, 6 months using SIENAX Multi Time Point (SX-MTP) algorithms. Immunological status was also determined correlations between subsets T cells assessed. Interferon SC tiw...
The Health Quality & Safety Commission New Zealand commissioned Ko Awatea, an innovation and improvement centre, to deliver a co-design programme nine teams of healthcare providers. was part Partners in Care, broader developed 2012 support enable patient engagement participation across the health disability sector. Teams received training, guidance mentorship Experience Based Design (EBD) methodology.1 We evaluated explore barriers facilitators sustainability projects EBD approach....