A5055648634- Multiple Sclerosis Research Studies
- Advanced Neuroimaging Techniques and Applications
- Systemic Lupus Erythematosus Research
- Advanced MRI Techniques and Applications
- Peripheral Neuropathies and Disorders
- RNA regulation and disease
- Functional Brain Connectivity Studies
- Ultrasound and Hyperthermia Applications
- Cerebral Venous Sinus Thrombosis
- Ultrasound Imaging and Elastography
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Neurological Disease Mechanisms and Treatments
- Polyomavirus and related diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Systemic Sclerosis and Related Diseases
- Rheumatoid Arthritis Research and Therapies
- Cerebrospinal fluid and hydrocephalus
- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Radiomics and Machine Learning in Medical Imaging
- Bone and Joint Diseases
- Neurogenesis and neuroplasticity mechanisms
- Genetic Neurodegenerative Diseases
- Long-Term Effects of COVID-19
University at Buffalo, State University of New York
2016-2025
Don Carlo Gnocchi Foundation
2015-2024
Buffalo Psychiatric Center
2015-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2021
Charles University
2020-2021
The University of Melbourne
2020-2021
The Royal Melbourne Hospital
2020-2021
General University Hospital in Prague
2020-2021
Jacobs (United States)
2018-2021
Jacobs Institute
2007-2021
The breakdown of the blood-brain-barrier vascular endothelium is critical for entry immune cells into MS brain. Vascular co-morbidities are associated with increased risk progression. Dyslipidemia, elevated LDL and reduced HDL may increase progression by activating inflammatory processes at endothelium. To assess associations serum lipid profile variables (triglycerides, high low density lipoproteins (HDL, LDL) total cholesterol) disability MRI measures in multiple sclerosis (MS). This study...
<h3>Objectives</h3> To identify MRI biomarkers associated with long-term disability progression in patients multiple sclerosis (MS), and to define the rate of evolution global, tissue-specific regional atrophy MS over long-term. <h3>Methods</h3> brain clinical neurological assessment was performed 81 at time first visit after 5 10 years follow-up. acquired on 1.5 T scanners. T1-lesion T2-lesion volumes (LVs) were calculated. Global changes longitudinally assessed, using a direct measurement...
Purpose To investigate the association between development of thalamic and cortical atrophy conversion to clinically definite multiple sclerosis (CDMS) in patients with isolated syndrome (CIS). Materials Methods This prospective study was approved by institutional review board. Informed consent given 216 CIS patients, were treated 30 µg intramuscular interferon β1a once a week. They assessed magnetic resonance (MR) imaging examination at baseline, 6 months, 1 year, 2 years. Patients...
<h3>BACKGROUND AND PURPOSE:</h3> Recent studies have shown that selective regional, but not global, GM atrophy occurs from clinical onset to conversion clinically definite MS. Our aim was investigate the difference in extent of SDGM and cortical a large sample patients with CIS early RRMS explore relationship between other MR imaging outcomes. <h3>MATERIALS METHODS:</h3> Two hundred twelve recruited at first event (mean age, 29.3 years; median EDSS, 1.5; disease duration, 3 months) 177 30.7...
<h3>Background</h3> Cardiovascular (CV) risk factors have been associated with changes in clinical outcomes patients multiple sclerosis (MS). <h3>Objectives</h3> To investigate the frequency of CV risks MS and their association MRI outcomes. <h3>Methods</h3> In a prospective study, 326 relapsing–remitting 163 progressive MS, 61 clinically isolated syndrome (CIS) 175 healthy controls (HCs) were screened for scanned on 3T scanner. Examined included hypertension, heart disease, smoking,...
<h3>Objectives</h3> To investigate the associations of serum lipid profile with disease progression in high-risk clinically isolated syndromes (CIS) after first demyelinating event. <h3>Methods</h3> High density lipoprotein cholesterol (HDL-C), low (LDL-C) and total (TC) were obtained pretreatment from 135 high risk patients CIS (≥2 brain MRI lesions ≥2 oligoclonal bands) enrolled Observational Study Early Interferon β-1a Treatment Risk Subjects study (SET study), which prospectively...
Background: Deep gray matter (DGM) atrophy is common in multiple sclerosis (MS), but no studies have investigated surface-based structure changes over time with respect to healthy controls (HCs). Moreover, the relationship between cognition and spatio-temporal evolution of DGM poorly understood. Objectives: To explore structural differences MS HCs relation neuropsychological (NP) outcomes. Methods: The participants were 44 relapsing-remitting 20 secondary progressive patients 22 HCs. All...
Background: Leptomeningeal contrast enhancement (LM CE) has been recently described in multiple sclerosis (MS) patients as a potential vivo marker of cortical pathology. Objectives: To investigate the association LM CE and development atrophy 50 MS (27 relapsing-remitting (RR) 23 secondary-progressive (SP)) followed for 5 years. Methods: The presence number foci were assessed only at 5-year follow-up using three-dimensional (3D) fluid-attenuated inversion recovery magnetic resonance imaging...
Purpose To study deep gray matter susceptibility in multiple sclerosis (MS) by using quantitative mapping (QSM) and to assess the relationship between clinical disability. Materials Methods For this prospective March 2009 November 2013, 600 participants with MS (452 relapsing-remitting 148 secondary progressive MS) 250 age- sex-matched healthy control were imaged 3.0-T MRI measure magnetic susceptibility. Deep (in parts per billion) was analyzed region of interest voxelwise methods. QSM...
Cardiovascular diseases (CVDs) are more frequent in multiple sclerosis (MS) patients when compared to controls. In particular, CVDs linked with higher accumulation of lesions and advanced brain atrophy.To investigate whether contribute accelerated lesion atrophy over 5 years MS.194 MS 43 controls without neurologic disease were followed for years. Full physical, neurological evaluation, structured questionnaire investigating CVD risk factors (hypertension, hyperlipidemia, heart disease,...
Inflammation of the choroid plexus (CP) has been reported in multiple sclerosis (MS). The AU1 association between CP inflammation and clinical disability progression is still under debate. objective current study was to assess relationship measures investigate their associations with MS.In this retrospective analysis a longitudinal study, 174 patients MS (118 relapsing-remitting 56 progressive [PMS]) healthy controls (HCs), group matched for age sex, were imaged on 3T MRI scanner at baseline...
Background: Paramagnetic rim lesions (PRLs) have been linked to higher clinical disease severity and relapse frequency. However, it remains unclear whether PRLs predict future, long-term progression. Objectives: The study aimed assess baseline were associated with subsequent (10 years) Expanded Disability Status Scale (EDSS) increase frequency and, if so, PRL-associated EDSS was mediated by relapse. Methods: This retrospective analysis included 172 people multiple sclerosis (pwMS) 1868...
A quantitative measurement of serum proteome biomarkers that would associate with disease progression endpoints can provide risk stratification for persons multiple sclerosis (PwMS) and supplement the clinical decision-making process.
Pathologic changes in GM have an important role MS. We investigated the association between SDGM and cortical volume disability progression early RRMS.One hundred eighty patients with RRMS had clinical assessment during 5 years were divided into those or without SDP at by usual definition treatment trials. The number of available MR imaging scans various time points was following: baseline, 178; 6 months, 172; 12 175; 24 155; 36 160; 48 158; 60 162, respectively. Longitudinal cortical, GM,...
Gray-matter (GM) atrophy is strongly predictive of cognitive impairment in multiple sclerosis (MS) patients. The thalamus the region where atrophy/cognition correlation most robust. However, few studies have assessed diffusion tensor imaging (DTI) metrics within thalamus.This study was designed to determine if white matter DTI predicts after accounting for effects volume loss.We enrolled 75 MS patients and 18 healthy controls undergoing 3T brain magnetic resonance (MRI). Thalamus volumes...
We report three cases of dural arteriovenous fistula (DAVF) the cavernous sinus treated by Onyx injection through superior pharyngeal branch ascending artery. The treatment choice DAVFs is endovascular, and it preferentially done via transvenous occlusion sinus. can be reached either inferior petrosal or ophthalmic vein. When these venous routes are occluded, first attempt to pass occluded sinus, but sometimes this fail. In some there small transosseous feeders arising from all more...
Several studies have reported hypoperfusion of the brain parenchyma in multiple sclerosis (MS) patients. We hypothesized a possible relationship between abnormal perfusion MS and hampered venous outflow at extracranial level, condition possibly associated with known as chronic cerebrospinal insufficiency (CCSVI). investigated CCSVI cerebral 16 patients 8 age- sex-matched healthy controls. Subjects were scanned 3-T scanner using dynamic susceptibility, contrast-enhanced, perfusion-weighted...
<h3>Background and objective</h3> Cognitive impairment, including impairment of episodic memory, is frequently found in newly diagnosed Parkinson9s disease (PD). In this longitudinal observational study we investigated whether performance memory encoding, retention, recognition free recall associated with reduced hippocampal radial distance. <h3>Methods</h3> We analysed baseline T1-weighted brain MRI data from 114 PD subjects without cognitive 29 mild 99 normal controls the ParkWest study....
Objectives To investigate the associations of environmental MS risk factors with clinical and MRI measures progression in high-risk clinically isolated syndromes (CIS) after first demyelinating event. Methods We analyzed 211 CIS patients (age: 28.9±7.8 years) enrolled SET study, a multi-center study patients. Pre-treatment samples were for IgG antibodies against cytomegalovirus (anti-CMV), Epstein Barr virus (EBV) early nuclear antigen-1 (EBNA-1), viral capsid antigen (VCA), antigen-diffuse...