A5085028391- Multiple Sclerosis Research Studies
- Cerebral Venous Sinus Thrombosis
- Systemic Lupus Erythematosus Research
- Advanced Neuroimaging Techniques and Applications
- RNA regulation and disease
- Ultrasound and Hyperthermia Applications
- Smoking Behavior and Cessation
- Venous Thromboembolism Diagnosis and Management
- Behavioral Health and Interventions
- Polyomavirus and related diseases
- Acute Ischemic Stroke Management
- Vestibular and auditory disorders
- Herpesvirus Infections and Treatments
- Peripheral Neuropathies and Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Pathogenesis and Treatment of Hiccups
- Advanced MRI Techniques and Applications
- Transcranial Magnetic Stimulation Studies
- Neural and Behavioral Psychology Studies
- Ultrasound Imaging and Elastography
- Bone and Joint Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Cancer-related cognitive impairment studies
- Acute Lymphoblastic Leukemia research
Roswell Park Comprehensive Cancer Center
2020-2025
University at Buffalo, State University of New York
2011-2020
Buffalo Psychiatric Center
2010-2019
Jacobs (United States)
2018
Jacobs Institute
2014-2015
State University of New York
2013
University of Bradford
2013
Buffalo State University
2009-2013
Pain Management Institute
2012
The University of Texas Southwestern Medical Center
2012
The breakdown of the blood-brain-barrier vascular endothelium is critical for entry immune cells into MS brain. Vascular co-morbidities are associated with increased risk progression. Dyslipidemia, elevated LDL and reduced HDL may increase progression by activating inflammatory processes at endothelium. To assess associations serum lipid profile variables (triglycerides, high low density lipoproteins (HDL, LDL) total cholesterol) disability MRI measures in multiple sclerosis (MS). This study...
Purpose To investigate the association between development of thalamic and cortical atrophy conversion to clinically definite multiple sclerosis (CDMS) in patients with isolated syndrome (CIS). Materials Methods This prospective study was approved by institutional review board. Informed consent given 216 CIS patients, were treated 30 µg intramuscular interferon β1a once a week. They assessed magnetic resonance (MR) imaging examination at baseline, 6 months, 1 year, 2 years. Patients...
<h3>Background</h3> Cardiovascular (CV) risk factors have been associated with changes in clinical outcomes patients multiple sclerosis (MS). <h3>Objectives</h3> To investigate the frequency of CV risks MS and their association MRI outcomes. <h3>Methods</h3> In a prospective study, 326 relapsing–remitting 163 progressive MS, 61 clinically isolated syndrome (CIS) 175 healthy controls (HCs) were screened for scanned on 3T scanner. Examined included hypertension, heart disease, smoking,...
Purpose To study deep gray matter susceptibility in multiple sclerosis (MS) by using quantitative mapping (QSM) and to assess the relationship between clinical disability. Materials Methods For this prospective March 2009 November 2013, 600 participants with MS (452 relapsing-remitting 148 secondary progressive MS) 250 age- sex-matched healthy control were imaged 3.0-T MRI measure magnetic susceptibility. Deep (in parts per billion) was analyzed region of interest voxelwise methods. QSM...
Several studies have reported hypoperfusion of the brain parenchyma in multiple sclerosis (MS) patients. We hypothesized a possible relationship between abnormal perfusion MS and hampered venous outflow at extracranial level, condition possibly associated with known as chronic cerebrospinal insufficiency (CCSVI). investigated CCSVI cerebral 16 patients 8 age- sex-matched healthy controls. Subjects were scanned 3-T scanner using dynamic susceptibility, contrast-enhanced, perfusion-weighted...
Abstract Purpose: To investigate phase lesions identified on susceptibility‐weighted imaging (SWI)‐filtered images in patients with multiple sclerosis (MS), clinically isolated syndrome (CIS) and healthy controls (HC). relate lesion characteristics to other clinical MRI outcomes. Materials Methods: 95 relapsing‐remitting (RR), 40 secondary‐progressive (SP) MS patients, as well 19 CIS 49 age‐ sex‐matched HC, were scanned a 3T scanner. Phase‐, T1‐, T2‐lesion determined. Overlap of T1‐...
The potential pathogenesis between the presence and severity of chronic cerebrospinal venous insufficiency (CCSVI) its relation to clinical imaging outcomes in brain parenchyma multiple sclerosis (MS) patients has not yet been elucidated. aim study was investigate relationship CCSVI, altered vasculature visibility (VVV) on susceptibility-weighted (SWI) with MS sex- age-matched healthy controls (HC). 59 patients, 41 relapsing-remitting 18 secondary-progressive, 33 HC were imaged a 3T GE...
Background: Cognitive decline is characterized in multiple sclerosis (MS), but the rate and severity vary. The reserve hypothesis proposes that baseline neurological differences impact cognitive outcome neurodegenerative disease. Objective: To elucidate how brain influence subcortical gray matter (SCGM) atrophy MS over 3 years. Methods: Seventy-one patients 23 normal controls underwent magnetic resonance imaging assessment at 3-year follow-up. of on processing speed (CPS) memory was...
ABSTRACT BACKGROUND AND PURPOSE Brain atrophy accelerates at the age of 60 in healthy individuals (HI) and disease onset multiple sclerosis (MS) patients. Whether there is an exacerbating effect aging superimposed on MS‐related brain unknown. We estimated lateral ventricular volume (LVV) whole (WBV) changes MS METHODS 1,982 patients (mean follow‐up: 4.8 years) 351 HI 3.1 years), aged from 20 to 79 years old (yo), were collected retrospectively. Percent LVV change (PLVVC) percent (PBVC) 1.5T...
Cigarette smoking is an important risk factor in the development of dyspnea. Programs designed to strengthen respiratory muscles can improve dyspnea people with or without lung disease. As a first step understanding feasibility offering muscle training (RMT) program who are seeking help try quit smoking, we asked callers contacted New York State Quitline about their and potential interest home-based RMT program. Consecutive (n=1019) between 19 May 9 June 2023 completed Modified Medical...
<h3>BACKGROUND AND PURPOSE:</h3> Increasing evidence suggests that iron deposition is present in the later stages of MS. In this study we examined abnormal phase values, indicative increased content on SWI-filtered images SDGM CIS patients and HC. We also association with conventional MR imaging outcomes at first clinical onset. <h3>MATERIALS METHODS:</h3> Forty-two (31 female, 11 male) 65 age sex-matched HC (41 24 were scanned a 3T scanner. Mean was 40.1 (SD = 10.4) years CIS, 42.8 14) HC,...
<h3>BACKGROUND AND PURPOSE:</h3> The association between subcortical deep gray matter, white and cortical pathology is not well understood in MS. aim of this study was to use DTI investigate the matter alterations their relationship with lesion burden, atrophy patients MS healthy control patients. <h3>MATERIALS METHODS:</h3> A total 210 relapsing-remitting MS, 75 progressive 110 were included study. metrics whole brain, normal-appearing structures compared. normalized volume, volume...
We report the results of investigation safety and efficacy venous angioplasty in patients with multiple sclerosis (MS) findings extracranial anomalies, considered hallmarks chronic cerebrospinal insufficiency (CCSVI), a 2-phase study (ClinicalTrials.gov NCT01450072).Phase 1 was an open-label (10 patients); phase 2 sham-controlled, randomized, double-blind sham procedure, 9 treated). All fulfilled hemodynamic screening criteria indicative CCSVI. Assessment at 1, 3, 6 months postprocedure MRI,...
Because dysregulated Epstein-Barr virus (EBV)-infected B cells may induce meningeal inflammation, which contributes to cortical pathology in multiple sclerosis (MS), we investigated associations between antibody responses EBV and development of MS.We included 539 patients with MS (369 relapsing-remitting MS, 135 secondary progressive 35 primary MS), 66 clinically isolated syndrome (CIS), 63 other neurologic diseases (OND), 178 age- sex-matched healthy controls (HC). All participants were...
To investigate the factors associated with complementary and alternative medicine (CAM) usage by multiple sclerosis (MS) patients. Design, Setting/Location: Single-center, prospective clinical study at an academic MS center in northeastern United States.This included CAM data from 524 patients 304 healthy controls (HC) enrolled a of clinical, neuroimaging, environmental risk Center. Clinical, disease-modifying treatment were obtained. In addition, on modalities, including acupuncture,...
Background: Epstein–Barr virus (EBV) infection has been associated with higher clinical activity and risk of multiple sclerosis (MS). Objective: To evaluate associations between EBV-specific humoral response magnetization transfer ratio (MTR)-derived measure in MS patients healthy controls (HCs). Methods: The study included 101 (69 relapsing-remitting (RRMS) 32 secondary-progressive (SPMS)) 41 HCs who underwent clinical, serological, magnetic resonance imaging (MRI) investigations. MTR...
Abstract Despite remarkable progress, tobacco control efforts are not equitably distributed, and tobacco-related disparities continue to contribute significant health disparities. Our premise in this commentary is that Intersectionality can serve as a productive analytical framework for examining across within multiple marginalized populations. theoretical understanding the interlocking societal systems bestow privilege oppression increasingly being study of inequities. We present model...
Background The role of intra- and extra-cranial venous system impairment in the pathogenesis various vascular, inflammatory neurodegenerative neurological disorders, as well aging, has not been studied detail. Nor have risk factors determined for increased susceptibility pathology intra-cranial veins. aim this study was to investigate association between presence a newly proposed vascular condition called chronic cerebrospinal insufficiency (CCSVI) environmental large volunteer control group...
<h3>Purpose</h3> To assess the relationships of sun exposure history, supplementation and environmental factors to vitamin D levels in multiple sclerosis (MS) patients evaluate associations between MRI measures. <h3>Methods</h3> This study included 264 MS (mean age 46.9±10 years, disease duration 14.6±10 years; 67.8% relapsing–remitting, 28% secondary progressive 4.2% primary MS) 69 healthy controls. Subjects underwent neurological 3 T examinations, provided blood samples answered questions...
<h3>BACKGROUND AND PURPOSE:</h3> The assessment of brain atrophy in a clinical routine is not performed routinely multiple sclerosis. Our aim was to determine the feasibility measurement and its association with disability progression patients MS followed for 5 years. <h3>MATERIALS METHODS:</h3> A total 1815 subjects, 1514 137 clinically isolated syndrome 164 healthy individuals, were collected retrospectively. Of 11,794 MR imaging scans included analysis, 8423 MRIs on 3T, 3371 MRIs, 1.5T...
Chronic cerebrospinal venous insufficiency (CCSVI) is a vascular condition characterized by anomalies of the main extracranial routes that interfere with normal outflow. Research into CCSVI will determine its sensitivity and specificity for diagnosis MS, prevalence in MS patients, clinical, MRI, genetic correlates. Our aim was to investigate number intra- extraluminal structural functional abnormalities using DS MRV, patients HCs.One hundred fifty 104 (69.3%) RR 46 (30.7%) progressive...