A5023310876- Cerebral Venous Sinus Thrombosis
- Multiple Sclerosis Research Studies
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Advanced MRI Techniques and Applications
- Intracerebral and Subarachnoid Hemorrhage Research
- Venous Thromboembolism Diagnosis and Management
- Neurosurgical Procedures and Complications
- Advanced Neuroimaging Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- RNA regulation and disease
- Systemic Sclerosis and Related Diseases
- Ultrasound Imaging and Elastography
- Hemoglobinopathies and Related Disorders
- Neurological and metabolic disorders
- Vestibular and auditory disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Ultrasound and Hyperthermia Applications
- Fire dynamics and safety research
- Systemic Lupus Erythematosus Research
- Barrier Structure and Function Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Connexins and lens biology
- Multisensory perception and integration
- Digital Imaging for Blood Diseases
Buffalo Psychiatric Center
2011-2017
University at Buffalo, State University of New York
2005-2016
Buffalo State University
2010-2011
Toshiba (United States)
2005
University of Alabama at Birmingham
2005
Several studies have reported hypoperfusion of the brain parenchyma in multiple sclerosis (MS) patients. We hypothesized a possible relationship between abnormal perfusion MS and hampered venous outflow at extracranial level, condition possibly associated with known as chronic cerebrospinal insufficiency (CCSVI). investigated CCSVI cerebral 16 patients 8 age- sex-matched healthy controls. Subjects were scanned 3-T scanner using dynamic susceptibility, contrast-enhanced, perfusion-weighted...
Purpose To assess cerebral microbleed (CMB) prevalence in patients with multiple sclerosis (MS) and clinically isolated syndrome (CIS) associations clinical outcomes. Materials Methods CMBs are associated aging neurodegenerative disorders. The of has not previously been well established. In this study, 445 MS (266 relapsing-remitting MS, 138 secondary progressive 41 primary MS), 45 CIS, 51 other neurological diseases, 177 healthy control subjects (HCs) underwent 3-T magnetic resonance (MR)...
To investigate the differences in extracranial venous system patients with multiple sclerosis (MS) and healthy control (HC) subjects by using magnetic resonance (MR) venography.This HIPAA-compliant, prospective study was approved local institutional review board, all participants gave informed consent. Fifty-seven patients, 41 (72%) relapsing-remitting MS 16 (28%) secondary-progressive MS, 21 HC were imaged a 3-T MR unit two-dimensional (2D) time-of-flight (TOF) three-dimensional (3D)...
Abstract Purpose: To investigate phase lesions identified on susceptibility‐weighted imaging (SWI)‐filtered images in patients with multiple sclerosis (MS), clinically isolated syndrome (CIS) and healthy controls (HC). relate lesion characteristics to other clinical MRI outcomes. Materials Methods: 95 relapsing‐remitting (RR), 40 secondary‐progressive (SP) MS patients, as well 19 CIS 49 age‐ sex‐matched HC, were scanned a 3T scanner. Phase‐, T1‐, T2‐lesion determined. Overlap of T1‐...
<h3>BACKGROUND AND PURPOSE:</h3> CCSVI was recently described in patients with MS. is diagnosed noninvasively by Doppler sonography and invasively catheter venography. We assessed the role of conventional MRV for detection IJV anomalies MS healthy controls who underwent examinations during 6 months. <h3>MATERIALS METHODS:</h3> Ten TOF, TRICKS, sonography, venography at baseline. They were treated baseline percutaneous angioplasty re-evaluated months9 posttreatment sonography. In addition, a...
The potential pathogenesis between the presence and severity of chronic cerebrospinal venous insufficiency (CCSVI) its relation to clinical imaging outcomes in brain parenchyma multiple sclerosis (MS) patients has not yet been elucidated. aim study was investigate relationship CCSVI, altered vasculature visibility (VVV) on susceptibility-weighted (SWI) with MS sex- age-matched healthy controls (HC). 59 patients, 41 relapsing-remitting 18 secondary-progressive, 33 HC were imaged a 3T GE...
<h3>BACKGROUND AND PURPOSE:</h3> Increasing evidence suggests that iron deposition is present in the later stages of MS. In this study we examined abnormal phase values, indicative increased content on SWI-filtered images SDGM CIS patients and HC. We also association with conventional MR imaging outcomes at first clinical onset. <h3>MATERIALS METHODS:</h3> Forty-two (31 female, 11 male) 65 age sex-matched HC (41 24 were scanned a 3T scanner. Mean was 40.1 (SD = 10.4) years CIS, 42.8 14) HC,...
Abstract Purpose: To investigate cerebrospinal fluid (CSF) dynamics in the aqueduct of Sylvius multiple sclerosis (MS) patients and healthy controls (HC) using cine phase contrast imaging. Materials Methods: In all, 67 MS (48 relapsing‐remitting [RR] 19 secondary‐progressive [SP]), nine with clinically isolated syndrome (CIS), 35 age‐ sex‐matched HC were examined. CSF flow velocity measures quantified a semiautomated method compared clinical magnetic resonance imaging (MRI) disease outcomes....
<h3>BACKGROUND AND PURPOSE:</h3> It is well known that patients with MS tend to have abnormal iron deposition in and around the plaques, basal ganglia THA. In this study, we used SWI quantify content healthy volunteers. <h3>MATERIALS METHODS:</h3> Fifty-two were recruited assess their THA structures. One hundred twenty-two subjects establish a baseline of normal deep GM Each structure was separated into 2 regions: low-iron-content region high-iron-content region. The average phase,...
Purpose To investigate cerebrospinal fluid (CSF) dynamics in the aqueduct of Sylvius (AoS) chronic venous insufficiency (CCSVI)‐positive and ‐negative healthy individuals using cine phase contrast imaging. Materials Methods Fifty‐one (32 CCSVI‐negative 19 age‐matched CCSVI‐positive subjects) were examined Doppler sonography (DS). Diagnosis CCSVI was established if subjects fulfilled ≥2 hemodynamic criteria on DS. CSF flow velocity measures quantified a semiautomated method compared with...
<h3>BACKGROUND AND PURPOSE:</h3> It has been demonstrated that increased levels of iron in the brain occur with aging. In this study we investigated nature association between age and SWI-filtered phase values, indicative content, subcortical deep gray matter healthy individuals. <h3>MATERIALS METHODS:</h3> A total 210 individuals (men: <i>n</i> = 89, women: 121), mean age, 39.8 years (standard deviation 15.5; range 6–76 years), were imaged on a 3T scanner. Mean MRI phase, low-phase voxels,...
<h3>BACKGROUND AND PURPOSE:</h3> Arterial and neck vessel system characteristics of patients with multiple sclerosis have not been previously investigated. Therefore, the aim this study was to examine frequency vessels their cross-sectional areas (in square millimeters) between MS healthy controls. <h3>MATERIALS METHODS:</h3> In study, 193 age- sex-matched controls underwent 2D TOF venography at 3T. The main arterial (carotid vertebral), venous (internal jugular), secondary were examined 4...
Internal jugular vein (IJV) narrowing has been implicated in central nervous system pathologies, however normal physiological age- and gender-related IJV variance healthy individuals (HIs) not adequately assessed.We assessed the relationship between cross-sectional area (CSA) aging.This study involved 193 HIs (63 males 130 females) who received 2-dimensional magnetic resonance venography at 3T. The minimum CSA of IJVs cervical levels C2/C3, C4, C5/C6, C7/T1 was obtained using a...
Abstract Contrast optimization of a three‐dimensional (3D) Fluid‐attenuated inversion recovery (FLAIR) sequence is examined in the context multiple sclerosis. In order to develop 3D FLAIR for enhanced detection lesions, an iterative approach based on theoretical considerations was used. The systematically acquired with incremental parameter changes single subject sclerosis 3‐T MRI scanner. Region interest analysis performed images, and best estimate optimal acquisition parameters...
Introduction Masking level differences (MLDs) are in the hearing threshold for detection of a signal presented noise background, where either phase or is reversed between ears. We use N0/Nπ to denote in-phase/out-of-phase ears and S0/Sπ 500 Hz sine wave as in/out-of-phase. Signal noise/signal combinations N0Sπ NπS0 typically 10–20 dB better than N0S0. All have same spectrum, level, duration both noise. Methods Ten participants (5 female), age: 22–43, with N0Sπ-N0S0 MLDs greater 10 dB, were...
ABSTRACT BACKGROUND AND PURPOSE Aging of the healthy brain is characterized by focal or nonfocal white matter (WM) signal abnormality (SA) changes, which are typically detected as leukoaraiosis (LA). Hypertension a risk factor for WM lesion formation. This study investigated whether LA might be associated with increased cerebrospinal fluid (CSF) pulsatility linked to arterial hypertension. METHODS A total 101 individuals without neurologic diseases (53 females and 48 males) aged between 18...
Constricted cerebral venous outflow has been linked with increased cerebrospinal fluid (CSF) pulsatility in the aqueduct of Sylvius multiple sclerosis (MS) patients and healthy individuals. This study investigates relationship between CSF internal jugular vein (IJV) cross-sectional area (CSA) these two groups, something previously unknown.65 relapsing-remitting MS (50.8% female; mean age = 43.8 years) 74 controls (HCs) (54.1% 43.9 were investigated. flow quantification was performed on cine...
Internal jugular vein (IJV) narrowing has been implicated in central nervous system (CNS) disorders. Body mass index (BMI) is a cardiovascular risk factor that also linked to CNS diseases, however it unknown whether relationship exists between IJV and BMI. The objectives were assess the cross-sectional areas (CSA) BMI healthy individuals (HI) multiple sclerosis (MS) patients. A total of 388 subjects (194 age- sexmatched HI MS patients) received magnetic resonance venography structural brain...
To determine the sensitivity and specificity of decreased venous vasculature visibility (VVV) on susceptibility-weighted imaging (SWI) venography in multiple sclerosis (MS) patients versus controls, to compare this with assessment whole brain atrophy.Forty MS 22 controls without known central nervous system (CNS) disease who had non-specific white-matter (WM) lesions were imaged a 3T GE scanner using SWI venography. Apparent total volume (ATVV) increased average distance from vein (DFV)...
Objectives To assess the relationship between cross-sectional area of internal jugular veins and brain volumes in healthy individuals without neurologic disease. Methods A total 193 disease (63 male 130 female; age > 20 to < 70 years) received magnetic resonance venography structural imaging at 3T. The vein was assessed C2–C3, C4, C5–C6, C7–T1. Normalized whole volume assessed. Partial correlation analyses were used determine associations. Results There an inverse normalized (C7–T1:...