A5073309359- Cerebral Venous Sinus Thrombosis
- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Vascular Malformations Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Multiple Sclerosis Research Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Cerebrospinal fluid and hydrocephalus
- Neurosurgical Procedures and Complications
- Herpesvirus Infections and Treatments
- Infectious Encephalopathies and Encephalitis
- Blood Coagulation and Thrombosis Mechanisms
- Neurological Complications and Syndromes
- MRI in cancer diagnosis
- Systemic Sclerosis and Related Diseases
- Lanthanide and Transition Metal Complexes
- Intracranial Aneurysms: Treatment and Complications
- Technology and Security Systems
- Image Processing Techniques and Applications
- Advanced Computing and Algorithms
- RNA regulation and disease
Magnetic Resonance Innovations (United States)
2012-2021
Magnetic Resonance Imaging Institute for Biomedical Research
2014-2021
Purpose To assess cerebral microbleed (CMB) prevalence in patients with multiple sclerosis (MS) and clinically isolated syndrome (CIS) associations clinical outcomes. Materials Methods CMBs are associated aging neurodegenerative disorders. The of has not previously been well established. In this study, 445 MS (266 relapsing-remitting MS, 138 secondary progressive 41 primary MS), 45 CIS, 51 other neurological diseases, 177 healthy control subjects (HCs) underwent 3-T magnetic resonance (MR)...
The hallmark of pediatric cerebral malaria (CM) is sequestration parasitized red blood cells in the microvasculature. Malawi-based research using 0.35 Tesla (T) magnetic resonance imaging (MRI) established that severe brain swelling associated with fatal CM, but etiology remains unclear. Autopsy and clinical studies suggest several potential etiologies, limitations T MRI precluded optimal investigations into pathophysiology. A 1.5 Zambia allowed for further including susceptibility-weighted...
White matter hyperintensities (WMH) seen on T2WI are a hallmark of multiple sclerosis (MS) as it indicates inflammation associated with the disease. Automatic detection WMH can be valuable in diagnosing and monitoring treatment effectiveness. T2 fluid attenuated inversion recovery (FLAIR) MR images provided good contrast between lesions other tissue; however signal intensity gray tissue was close to FLAIR that may cause more false positives segment result. We developed evaluated tool for...
To study blood flow characteristics through the internal jugular veins (IJVs) at cervical levels C2/C3 and C5/C6 in neck of multiple sclerosis (MS) patients.Magnetic resonance imaging 3T was performed on 323 MS patients. Phase contrast used to quantify both levels. Total IJV (tIJF) normalized by total arterial (tAF). Contrast-enhanced time-resolved 3D MR arteriovenography 2D time-of-flight venography were assess anatomy. Based this assessment, population divided into non-stenotic (NST)...
ABSTRACT BACKGROUND To determine if extracranial venous structural and flow abnormalities exist in patients with multiple sclerosis (MS). METHODS Magnetic resonance imaging was used to assess the anatomy function of major veins neck 138 MS 67 healthy controls (HC). Time‐of‐flight MR angiography (MRA) stenosis while 2‐dimensional phase‐contrast quantification at C2/C3 C5/C6 levels. Venous normalized total arterial flow. The were divided into stenotic (ST) nonstenotic (NST) groups based on MRA...
The presence of abnormal anatomy and flow in neck veins has been recently linked to neurological diseases. precise impact extra-cranial abnormalities such as stenoses remains unexplored.Pressure velocity fields the full cardiovascular system are computed by means a global mathematical model that accounts for relationship between pulsating cerebral blood intracranial pressure.Our predicts strictures cause increased pressure venous system. Specifically, there is predicted increase about 10%...
Purpose: To evaluate the cerebral venous drainage system of swine as a probable model to test whether extracranial abnormalities may play role in neurodegenerative diseases reported recently multiple sclerosis. Materials and Methods: Three Yucatan micropigs, 5 7 months old, were scanned with comprehensive MRI protocol at 3 Tesla. The vascular anatomy head neck was imaged using conventional angiographic MR sequences. Phase‐contrast images collected levels intracranial space monitor flow....
<h3>BACKGROUND AND PURPOSE:</h3> A comprehensive parameter model was developed to investigate correlations between cerebral hemodynamics and alterations in the extracranial venous circulation due posture changes and/or obstruction (stenosis). The purpose of this work validate simulation results by using MR imaging echo-color Doppler experimental blood flow data humans. <h3>MATERIALS METHODS:</h3> To outcomes, we used supine average arterial extracerebral flow, obtained phase-contrast from 49...
To date, research on extracranial venous collaterals has been focused structure, with relatively little attention paid to hemodynamics. We addressed this limitation by quantitatively comparing collateral flow in patients multiple sclerosis and healthy controls using phase-contrast MR imaging. hypothesize that MS structurally anomalous internal jugular veins will have elevated compared controls.The sample consisted of 276 106 controls. used MRV classify as stenotic nonstenotic based an...
Magnetic resonance imaging (MRI) is a sensitive modality for identifying inflammatory and/or demyelinating lesions, which critical clinical diagnosis of MS and evaluating drug responses. There are many unique means probing brain tissue status, including conventional T1 T2 weighted (T1WI, T2WI), fluid attenuated inversion recovery (FLAIR), magnetization transfer, myelin water fraction, diffusion tensor (DTI), phase-sensitive susceptibility (SWI), but no study has combined all these modalities...
We studied cerebrospinal fluid (CSF) flow dynamics at the cervical level in association with internal jugular veins (IJV) for 92 patients multiple sclerosis (MS). Phase contrast magnetic resonance imaging was used to quantify of CSF and major vessels (including IJV carotid arteries) C2-C3 neck. Contrast enhanced MR angiography time-of-flight venography were subdivide MS into stenotic (ST) non-stenotic (NST) populations. evaluated: normalized by arterial flow; peaks; outflow duration its...
We hypothesized that cerebral microbleeds (CMBs) in multiple sclerosis (MS) patients will be detected with higher prevalence compared to healthy controls (HC) and quantitative susceptibility mapping (QSM) help remove false positives seen weighted imaging (SWI). A cohort of 100 relapsing remitting MS subjects scanned at 3T were used validate a set CMB detection guidelines specifically using QSM. second longitudinal 112 25 HCs, also acquired 3T, was reviewed across two time points. Both...
The study of chronic cerebrospinal venous insufficiency (CCSVI) and its impact on the development progression multiple sclerosis (MS) remains controversial. Although initial thrust in evaluating CCSVI was with ultrasound, other modalities including magnetic resonance imaging (MRI) have been used to vascular abnormalities. This review focuses findings a number past MRI studies look at combined four previous works cohort 559 MS patients regarding structure function extra-cranial vasculature....
Alterations in the extracranial venous circulation due to posture changes, and/or obstructions patients with vascular diseases, can have important implications on cerebral hemodynamics. A hemodynamic model for study of outflow was developed investigate correlations between blood redistributions and changes intracranial environment. Flow data obtained both magnetic resonance (MR) Echo-Color Doppler (ECD) technique are used validate model. The very good agreement simulated supine upright flows...