A5047472485- Fetal and Pediatric Neurological Disorders
- Advanced MRI Techniques and Applications
- Neonatal and fetal brain pathology
- Advanced Neuroimaging Techniques and Applications
- MRI in cancer diagnosis
- Pregnancy and preeclampsia studies
- Prenatal Screening and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Atomic and Subatomic Physics Research
- Multiple Sclerosis Research Studies
- Cerebral Venous Sinus Thrombosis
- Stress Responses and Cortisol
- Cancer, Hypoxia, and Metabolism
- Photoacoustic and Ultrasonic Imaging
- Systemic Sclerosis and Related Diseases
- Mitochondrial Function and Pathology
- Functional Brain Connectivity Studies
- Child Abuse and Trauma
- Nerve injury and regeneration
- Comparative Animal Anatomy Studies
- Metabolism and Genetic Disorders
- Congenital Diaphragmatic Hernia Studies
- Underwater Acoustics Research
- Nanoplatforms for cancer theranostics
- Lanthanide and Transition Metal Complexes
Wayne State University
2013-2022
Abstract : Our two objectives were to evaluate the feasibility of fetal brain magnetic resonance imaging (MRI) using a fast spin echo sequence at 3.0T field strength with low radio frequency ( T2 weighted images 1.5T compared similar data obtained in same fetus modified 3.0T. Quantitative whole-body SAR and normalized image signal noise ratio (SNR), nominal scoring scheme based evaluation diagnostic quality, tissue contrast conspicuity for specific anatomical structures between Twelve...
There is an urgent need for better detection and understanding of vascular abnormalities at the micro-level, where critical nourishment cellular metabolic changes occur. This especially case structures such as midbrain both feeding draining vessels are quite small. Being able to monitor diagnose earlier will aid in etiology disease development therapeutics. In this work, thirteen healthy volunteers were scanned with a dual echo susceptibility weighted imaging (SWI) sequence, resolution 0.22...
The hippocampus is a small but complex grey matter structure that plays an important role in spatial and episodic memory can be affected by wide range of pathologies including vascular abnormalities. In this work, we introduce the use Ferumoxytol, ultra-small superparamagnetic iron oxide (USPIO) agent, to induce susceptibility arteries (as well as increase veins) map hippocampal micro-vasculature evaluate quantitative change tissue fractional density (FVD), each its subfields. A total 39...
Purpose To evaluate fetal cerebral venous blood oxygenation, Y v , using principles of MR susceptometry. Materials and Methods A cohort 19 pregnant subjects, with a mean gestational age 31.6 ± 4.7 weeks were imaged modified susceptibility‐weighted imaging (SWI) sequence. Data quality was first assessed for feasibility oxygen saturation measurement, data from five subjects (mean std 33.7 3.6 weeks) then chosen further quantitative analysis. SWI phase in the superior sagittal sinus used to...
Multiple Sclerosis (MS) is a progressive, inflammatory, neuro-degenerative disease of the central nervous system (CNS) characterized by wide range histopathological features including vascular abnormalities. In this study, an ultra-small superparamagnetic iron oxide (USPIO) contrast agent, Ferumoxytol, was administered to induce increase in susceptibility for both arteries and veins help better reveal cerebral microvasculature. The purpose work examine presence abnormalities density MS...
Hypoxia is a hallmark of many diseases, including cancer, arthritis, heart and kidney diabetes, it often associated with disease aggressiveness poor prognosis. Consequently, there critical need for imaging hypoxia in noninvasive direct way to diagnose, stage, monitor the treatment development new therapies these diseases. Eu-containing contrast agents magnetic resonance have demonstrated potential vivo via changes metal oxidation state from +2 +3, but rapid blood limits EuII-containing...
Purpose To evaluate the feasibility of performing fetal brain magnetic resonance venography using susceptibility weighted imaging (SWI). Materials and Methods After obtaining informed consent, pregnant women in second third trimester were imaged a modified SWI sequence. Fetal acquisition was repeated when or maternal motion encountered. The median maximum number times an sequence four six respectively. All image data systematically evaluated by pediatric neuroradiologist for quality ordinal...
Magnetic resonance imaging (MRI) is a sensitive modality for identifying inflammatory and/or demyelinating lesions, which critical clinical diagnosis of MS and evaluating drug responses. There are many unique means probing brain tissue status, including conventional T1 T2 weighted (T1WI, T2WI), fluid attenuated inversion recovery (FLAIR), magnetization transfer, myelin water fraction, diffusion tensor (DTI), phase-sensitive susceptibility (SWI), but no study has combined all these modalities...
Background Volumetric assessment of afferent blood flow rate provides a measure global organ perfusion. Phase‐contrast magnetic resonance imaging (PCMRI) is reliable tool for volumetric quantification, but given the challenges with motion and lack physiologic gating signal, such studies, in vivo on human placenta, are scant. Purpose To evaluate apply nongated (ng) PCMRI technique quantifying rates utero umbilical vessels. Study Type Prospective study design. Population Twenty‐four pregnant...
<b><i>Objective:</i></b> To evaluate a dual-imaging modality approach to obtain combined estimation of venous blood oxygenation (S<i>νO</i><sub>2</sub>) using susceptibility-weighted magnetic resonance imaging (SWI-MRI), and perfusion power Doppler ultrasound (PDU) fractional moving volume (FMBV) in the brain normal growth growth-restricted fetuses. <b><i>Methods:</i></b> Normal (<i>n</i> = 33) fetuses 10)...
Mapping the vasculature, flow and tissue properties of placenta umbilical cord can serve as a means to study placental fetal health. The goal this work is use rapid, multi-echo, interleaved GRE sequence minimize motion artifacts cover entire abdomen mother in few minutes. To better map out we propose both separate arteries veins using an R2* mapping thresholding technique vessel tracking create 3D renderings. We have successfully done series 10 fetuses.
While non-invasive accurate quantification of fetal blood flow is important, this has been proven to be extremely difficult using ultrasound. Blood measurements are necessary for oxygen consumption rates MR-based oximetry. Due the challenges in obtaining a reliable cardiotocographic trigger phase contrast (PC) MRI fetuses, we explored possibility performing PC-MRI without an external estimate mean velocities umbilical vessels. We also evaluated systematic error Monte Carlo simulations and...
Visualization of the optic radiations is clinical importance for diagnosing many diseases and depicting their anatomic structures neurosurgical interventions. In this study, we quantify proton density, T1, T2*, susceptibility radiation fiber bundles in a series 10 healthy control participants using strategically acquired gradient echo imaging. Furthermore, introduce novel means to enhance contrast diamagnetic weighted
Non-invasive angiography could be useful in evaluating normal vs. abnormal vascular development of the human fetus and placenta. We report herein feasibility obtaining non-contrast MRA data during pregnancy to enable three dimensional (3D) MRI reconstruction fetal uteroplacental vasculature. MR imaging was performed using a 3.0 T under breathing conditions without sedation. The standard multislice two-dimensional time flight sequence used adults modified for imaging. acquisition per slice,...
The cerebral metabolic rate of oxygen (CMRO2) is a robust measure used to differentiate between normal and damaged brain tissue in neonates adults. objective this study was estimate the CMRO2 human fetus using quantitative measurements obtained from MRI Doppler ultrasound (DUS) compare such values with those neonates. Normal third trimester fetuses underwent both DUS. calculated as: CBF (cerebral blood flow ml/min/100 g) x OEF (oxygen extraction fraction %) Ca carrying capacity fetal blood)....
To estimate blood oxygen saturation and flow in the fetal brain using ultrasound (US) magnetic resonance imaging (MRI) techniques. Fetal venous was calculated 39 normally grown fetuses MR susceptometry. Brain perfusion evaluated by Doppler techniques measured 100 fetuses. All pregnancies were between 20 weeks of gestation. Blood middle cerebral artery (MCA) velocity-time integral (VTI) vessel diameter (VTI*MCA area) adjusted weight (Kg) cranial volume (cm3). Intracranial virtual organ...
Purpose: Our quick study here is to validate whether the quantified magnetic moments of same object are from different MRI machines and rf head coils. Methods: We constructed a gel phantom consisting an empty straw with diameter 2.6-mm, 3-mm glass bead, 5-mm bead. imaged 4 echo gradient sequence on 1.5-T Siemens Sonata 3-T Verio. On 1.5-T, we used quadrature single-channel birdcage coil 8-channel coil. 3-T, single channel circular-polarized (CP) receiving 12-channel coil, which outputs only...
In this work, we introduce the use of Ferumoxytol, an ultra-small superparamagnetic iron oxides (USPIO) agent, to increase susceptibility in veins and arteries map hippocampal microvasculature evaluate fractional vascular density (FVD) each its subfields. We found that fissure, along with fimbria, granular cell layer dentate gyrus cornu ammonis layers (except for CA1), showed higher microvascular FVD than other parts hippocampus.