A5052706697- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Advanced Glycation End Products research
- Neuroinflammation and Neurodegeneration Mechanisms
- Systemic Sclerosis and Related Diseases
- Ubiquitin and proteasome pathways
- Retinoids in leukemia and cellular processes
- Systemic Lupus Erythematosus Research
- Alzheimer's disease research and treatments
- Immune Response and Inflammation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Effects of Vibration on Health
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Protease and Inhibitor Mechanisms
- Natural product bioactivities and synthesis
- Lipoproteins and Cardiovascular Health
- Computational Drug Discovery Methods
- Acute Myeloid Leukemia Research
- Indigenous Studies and Ecology
- Climate change and permafrost
- Vibrio bacteria research studies
- Click Chemistry and Applications
- Phytochemistry and Biological Activities
- Geology and Paleoclimatology Research
- Healthcare Systems and Public Health
University of Ottawa
2022
Carleton University
2022
University at Buffalo, State University of New York
2009-2020
Jacobs Institute
2008-2020
Buffalo General Medical Center
2017
Roswell Park Comprehensive Cancer Center
2006-2009
Hamilton College
2001
The MS Functional Composite (MSFC) is a continuous scale of neurological disability for patients with multiple sclerosis (MS). Cognition represented by the Paced Auditory Serial Addition Test (PASAT), although Symbol Digit Modalities (SDMT) has been proposed as promising alternative. MSFC scores were calculated using either PASAT or SDMT following reference populations: National Multiple Sclerosis Society (NMSS) Task Force, 400 patients, and 100 normal controls. A subgroup 115 was followed...
Cognitive dysfunction is common in multiple sclerosis (MS), yet the magnitude of change on objective neuropsychological (NP) tests that clinically meaningful unclear. We endeavored to determine NP markers transition from employment work disability MS, as indicated by degree decline individual tests. Participants were 97 employed MS patients followed over 41.3 ± 17.6 months with a battery covering six domains cognitive function. Deterioration at follow-up was designated documented and paid...
The breakdown of the blood-brain-barrier vascular endothelium is critical for entry immune cells into MS brain. Vascular co-morbidities are associated with increased risk progression. Dyslipidemia, elevated LDL and reduced HDL may increase progression by activating inflammatory processes at endothelium. To assess associations serum lipid profile variables (triglycerides, high low density lipoproteins (HDL, LDL) total cholesterol) disability MRI measures in multiple sclerosis (MS). This study...
Multiple sclerosis (MS) patients are impaired in motor and cognitive performance, but the extent to which these deficits magnified by aging is unknown. In one prior study, differences processing speed between MS healthy individuals were of similar magnitude across lifespan. Here, we have improved on this work expanding assessment multiple domains functioning.To determine whether degree dysfunction with increasing age.In all, 698 (aged 29-71 years) 226 controls (HCs; aged 18-72 completed...
Cognitive impairment is common in multiple sclerosis (MS) but its manifestation as acute disease activity underappreciated.The aim of this study to examine recovery after MS relapse on tests cognitive and motor function explore correlates change with Expanded Disability Status Scale (EDSS), magnetic resonance imaging (MRI), reserve.Fifty relapsing group (RG) matched stable participants were examined at baseline, during relapse, 3-month follow-up. Tests processing speed (Symbol Digit...
Cognitive and motor abilities in multiple sclerosis (MS) are typically quantified using reliable, consensus standard tests validated the MS population. While these performance measures associated with vocational disability parametric analyses, translation of raw scores into anchors reflecting clinically relevant, functional impairment requires further research.To examine performance-based cognitive outcomes among definitive that designate varying degrees impairment, thereby establishing...
Objectives To compare serum levels of the receptor for advanced glycation end products (sRAGE) between multiple sclerosis (MS) patients and healthy control subjects, to investigate whether sRAGE correlate with MS disease severity as indicated by Kurtzke Expanded Disability Status Scale (EDSS). Method 37 clinical diagnosis 22 subjects were investigated in a cross-sectional study using enzyme-linked immunosorbent assays (ELISA). Results Serum found be significantly lower compared controls ( p...
The study is aimed to determine the role of luteolin (3',4',5,7-tetrahydroxyflavone), alone and in combination with human interferon-beta (IFN-β), modulating immune response(s) peripheral blood mononuclear cells (PBMCs) isolated from multiple sclerosis (MS) patients. PBMC proliferation presence or absence these drugs was determined production pro-inflammatory cytokines (IL-1β, TNF-α), ratio cell migration mediator MMP-9, its inhibitor, TIMP-1 assessed culture supernatants. Luteolin reduced,...
We previously reported that personality and cognition were stable over 3 years in patients with multiple sclerosis (MS). This study examined whether a longer duration would reveal evidence of emerging dysfunction. The NEO Five-Factor Inventory Brief International Cognitive Assessment for MS was used to assess cognition, respectively. Patients classified as “Cog Stable” or Decline” based on cognitive deterioration 5 years. Extraversion Conscientiousness declined across pooled groups....
We used the California Verbal Learning Test, Second Edition (CVLT-II), one component of Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS), to determine feasibility a remote assessment protocol. compared telephone-administered CVLT-II data from MS patients acquired in person an independent sample and healthy controls. Mixed factor analyses variance (ANOVAs) showed no significant differences between patient groups, but between-group effects comparing controls were...
Background: Previous research suggests that patients with multiple sclerosis (MS) have higher neuroticism, lower extraversion, and conscientiousness relative to healthy controls (HCs). However, the prevalence of this maladaptive profile in MS its relation cognition is unknown. Objective: Determine personality among patients, compared HCs, examine how it relates cognitive dysfunction. Methods: A sample 275 55 HCs completed neuroperformance measures information processing speed memory. Self...
Background: Impaired cognition and ambulation are common in multiple sclerosis (MS). Dalfampridine is the first Food Drug Administration (FDA)–approved medication to treat impaired MS. may benefit patients with cognitive impairment, given its effects on saltatory conduction association between motor function. Objective: To examine of dalfampridine determine if anticipated improved grounded dalfampridine’s ambulation. Methods: Adults MS were randomized ( n = 45) or placebo 16) for 12 weeks....
Personality changes and neuropsychiatric symptoms are found in multiple sclerosis (MS), but no study has evaluated decline compared to healthy controls. This assessed personality traits over 3 years using the NEO Five Factor Inventory Neuropsychiatric Inventory. Additional metrics ambulation, manual dexterity cognitive function. Contrary hypothesis, patients showed significant change or status relative Patients were impaired motor function at baseline follow-up, only slowing ambulation time....
Objective: Determine the influence of technician supervision on computer-administered cognitive tests in multiple sclerosis (MS). Methods: Eighty MS patients underwent assessment using CogState Brief Battery (CSBB) and Cleveland Clinic Cognitive (C3B). Each was administered twice, once with a guiding assessment, technician-absent. Twenty-eight healthy controls were also evaluated. Results: The guidance not statistically significant for group means either test. For CSBB, administration...
Objective: We endeavored to clarify how distinct co-occurring symptoms relate the presence of negative work events in employed multiple sclerosis (MS) patients. Latent profile analysis (LPA) was utilized elucidate common disability patterns by isolating patient subpopulations. Method: Samples 272 MS patients and 209 healthy controls (HC) were administered neuroperformance tests ambulation, hand dexterity, processing speed, memory. Regression-based norms created from HC sample. LPA identified...