A5101882728- Mesenchymal stem cell research
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Immune cells in cancer
- Endoplasmic Reticulum Stress and Disease
- Parkinson's Disease Mechanisms and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Fibroblast Growth Factor Research
- Sepsis Diagnosis and Treatment
- Diabetic Foot Ulcer Assessment and Management
- Osteoarthritis Treatment and Mechanisms
- Pancreatitis Pathology and Treatment
- Inflammasome and immune disorders
- Inflammation biomarkers and pathways
- Periodontal Regeneration and Treatments
- NF-κB Signaling Pathways
- Elder Abuse and Neglect
- Phytochemistry and Biological Activities
- Axon Guidance and Neuronal Signaling
- Chronic Kidney Disease and Diabetes
- Cancer Mechanisms and Therapy
- Retinal and Optic Conditions
- Aldose Reductase and Taurine
- Ocular Diseases and Behçet’s Syndrome
- Biomarkers in Disease Mechanisms
First Affiliated Hospital of Wenzhou Medical University
2011-2023
Wenzhou Medical University
2011-2023
Third Hospital of Nanchang
2018
Baylor College of Medicine
2017
Ocular Surface Center
2017
Qingdao University
2011-2012
Gaozhou People's Hospital
2009
Union Hospital
2008
Huazhong University of Science and Technology
2008
University of Miami
2001
Background/Aims: The rejuvenation properties of nanofat grafting have been described in recent years. However, it is not clear whether the clinical efficacy procedure attributable to stem cells or linked other components adipose tissue. In this study we isolated nanofat-derived (NFSCs) observe their biological characteristics and evaluate precise intradermal injection combined with platelet-rich fibrin (PRF) patients undergoing facial treatment. Methods: Third-passage NFSCs were cultured...
Acute kidney injury (AKI) is a serious clinical disease mainly caused by renal ischemia-reperfusion (I/R) injury, sepsis and nephrotoxic drugs. The pathologic mechanism of AKI very complex which may involve oxidative stress, inflammatory response, autophagy, apoptosis as well endoplasmic reticulum (ER) stress. Fibroblast growth factor 2 (FGF2) canonic member the FGF family plays crucial role in various cellular processes including organ development, wound healing tissue regeneration....
Abstract Background Acute lung injury (ALI), which is induced by numerous pathogenic factors, especially sepsis, can generate alveolar damage, pulmonary edema and vascular hyper-permeability ultimately leading to severe hypoxemia. Fibroblast growth factor-2 (FGF2) an important member of the FGF family associated with endothelial cell migration proliferation, repairment. Here, we conducted this study aiming evaluate therapeutic effect FGF2 in sepsis-induced ALI. Methods Recombinant was...
Background: Multiple trauma normally leads to acute lung injury (ALI) and other multiple organ dysfunction syndrome (MODS). Finding effective treatments for ALI remains a medical as well socioeconomic challenge. Several studies show that bone marrow mesenchymal stem cells (BMSCs) have the potent anti-inflammation activity transfusion of BMSCs can effectively inhibit inflammatory autoimmune diseases. Methods: In this study, we investigated TLR2, 4/NF-κB signaling pathway determine therapeutic...
ABSTRACT Sepsis is an aggressive and life-threatening systemic inflammatory response with a high mortality. Inflammation coagulation play crucial roles in the pathogenesis of sepsis mutually promoting manner. Unlike other single-target molecular therapies that have no obvious effects on clinical sepsis, bone marrow stromal cell (BMSC) therapy offers broader spectrum activities ranging from immune inflammation suppression to tissue regeneration. In this report, we demonstrate BMSC injection...
Introduction Coagulopathy plays an important role in sepsis. The aim of this study was to determine whether bone marrow stromal cell (BMSC) administration could attenuate coagulopathy
Background . Systemic inflammatory response syndrome (SIRS) accompanied by trauma can lead to multiple organ dysfunction (MODS) and even death. Early inhibition of the inflammation is necessary for damage control. Bone marrow mesenchymal stem cells (BMSCs), as a novel therapy modality, have been shown reduce responses in human animal models. Methods In this study, we used Western blot, quantitative PCR, enzyme-linked immunosorbent assay (ELISA) assess activity BMSCs suppress induced...
Despite lack of clinical therapy in acute kidney injury (AKI) or its progression to chronic disease (CKD), administration growth factors shows great potential the treatment renal repair and further fibrosis. At an early phase AKI, exogenous fibroblast factor 2 (FGF2) protects against by inhibition mitochondrial damage inflammatory response. Here, we investigated whether this attenuates long-term interstitial fibrosis induced ischemia-reperfusion (I/R) injury.Unilateral I/R with contralateral...
This article has no abstract.
Objective To investigate the effect of bone mesenchymal stem cells on Toll-like receptors (TLR) 2/4 expression in lungs rats with acute hemorrhagic necrotizing pancreatitis (AHNP). Methods Seventy SD male were randomly divided into sham-operation group (n=10), AHNP group(n=30) and MSCs-treated group(n=30). Masc rate BMSCs surface mark measured by flow cytometer. TLR2/4mRNA lung RT-PCR, The ratio Wet/dry histological changs observed. Results TLR2/4 mRNA could be detected low values group,...
Objective To investigate the effect of bone marrow-derived mesenchymal stem cells (MSCs) on gene and protein expression toll-like receptor, TLR2/4 rat alveolus macrophages so as to discuss MSCs transplantation early inflammatory mediators regulatory mechanism cascade.Methods The were randomly divided into PBS control group (n = 24), lipopolysaccharide (LPS) (n=24) LPS + treatment =24).All groups taken time-points 1, 3,6, 12 hours.Positive cell rate with surface mark level macrophage detected...
Objective To discuss surgical management of giant rhegnmatogenous retinal detachment with intraocular lens and aphakic eye.Methods 7cases were operated by pars plana vitrectomy combined perfluorocarbon,preretinal,membrane,peeling,endophotocogulation,cryopexy,and air 16% C3F8 in 2cases or siliconeoil 5cases temponade used to flatten the retina.Results The retina reattached 7 cases.1 case tamponade 2 cases was not reattached.The visual acuity improvedin postoperatively.Conclusion...
Objective To investigate the relationship between EphA7 protein and carcinogenesis development of pancreatic cancer by detecting expression in tissues. Methods The 10 cases normal tissue, 51 its adjacent tissues were detected with immunohistechemieal methods pathologic features analyzed. Results rate tissue was 10% (1/10), 47.1% (24/51) tissues, 94.1% (48/51) There significant difference among three groups (P 0.05). However there correlation degree differentiation, clinical staging, lymph...