A5055254899- Phytochemistry and Biological Activities
- Radiomics and Machine Learning in Medical Imaging
- Plant-based Medicinal Research
- Nanoplatforms for cancer theranostics
- Photochromic and Fluorescence Chemistry
- Traditional Chinese Medicine Analysis
- Neuroscience and Neuropharmacology Research
- Intraocular Surgery and Lenses
- Phytochemicals and Antioxidant Activities
- Analytical Chemistry and Chromatography
- Nanoparticle-Based Drug Delivery
- Bioactive Natural Diterpenoids Research
- Retinoids in leukemia and cellular processes
- Essential Oils and Antimicrobial Activity
- Biochemical Analysis and Sensing Techniques
- Traditional Chinese Medicine Studies
- Marine Sponges and Natural Products
- Atrial Fibrillation Management and Outcomes
- Autophagy in Disease and Therapy
- Nanocomposite Films for Food Packaging
- Plant-derived Lignans Synthesis and Bioactivity
- Sex and Gender in Healthcare
- Biological Activity of Diterpenoids and Biflavonoids
- Alkaloids: synthesis and pharmacology
- Patient-Provider Communication in Healthcare
Peking University
2018-2025
Peking University Third Hospital
2023-2025
University of Miami
2023
Henan Provincial People's Hospital
2023
Shanghai Jiao Tong University
2009-2022
Shandong First Medical University
2019-2022
Nantong University
2020-2022
Shanghai Institute of Hematology
2022
Ruijin Hospital
2022
Shanghai Institute of Pharmaceutical Industry
2021
Rivaroxaban is an oral Factor Xa inhibitor. The primary objective of this communication was to quantitatively predict changes in rivaroxaban exposure when individuals with varying degrees renal impairment are co-administered another drug that both a P-gp and moderate CYP3A4 inhibitor.A physiologically based pharmacokinetic (PBPK) model developed simulate pharmacokinetics young (20-45 years) or older (55-65 subjects normal function, mild, severe impairment, without concomitant use the...
[reaction: see text] 6-Bromo-4-(1,2-dihydroxyethyl)-7-hydroxycoumarin (Bhc-diol) can be used under simulated physiological conditions as a photoremovable protecting group for aldehydes and ketones. The single- two-photon-induced release of benzaldehyde, piperonal, acetophenone, cyclohexanone is demonstrated.
Tumor metastasis is a leading cause of breast cancer-related death. Taxane-loaded polymeric formulations, such as Genexol PM and Nanoxel M using poly(ethylene glycol)-poly(d,l-lactide) (PEG-PLA) micelles drug carriers, have been approved for the treatment metastatic cancer. Unfortunately, physical instability PEG-PLA micelles, to poor loading, premature leakage, consequently limited delivery tumors, largely hinders their therapeutic outcome. Inspired by enantiomeric nature PLA, this work...
Two unusual flavonones coupled with styryl units, communins A (1) and B (2), a new benzonaphthoxanthenone, ohioensin H (3), together 11 known compounds, were isolated from the moss Polytrichum commune. The structures of 1-3 assigned by spectroscopic data interpretation. compounds evaluated for cytotoxicity against small panel cancer cell lines.
Purpose . To investigate whether adding video assistance to traditional verbal informed consent advisement improved satisfaction among cataract surgery patients. Methods This trial enrolled 80 Chinese patients with age-related cataracts scheduled undergo unilateral phacoemulsification surgery. Patients were randomized into two groups: the group watched explaining cataract-related information and rewatched specific segments of at their own discretion, before receiving advisement; control did...
To investigate whether dexamethasone has an effect on functional expression of p-glycoprotein in cultured human RPE and, if so, this occurs through interaction with glucocorticoid receptor (GR) and pregnane X (PXR).The D407 was treated increasing concentrations and/or RU486 for various time periods up to 24 hours. Treated cells were collected cell viability, expressions PXR, rhodamine 123 accumulation assays. GR plasmid rifampicin chosen the relationship GR/PXR activation...
Abstract We aimed to investigate the pharmacokinetics, bioavailability and urinary excretion of scopolin its metabolite scopoletin in rats. An LC–tandem mass spectrometry (MS/MS) method for simultaneous determination rat biomatrices was developed validated over a plasma urine concentration range 5.0–2000 ng/mL. Chromatographic separation performed on Hypersil GOLD C 18 column with acetonitrile 0.1% formic acid water as mobile phase gradient elution. Detection positive ionization selected...
Xianglian pill, a TCM prescription, consists of Rhizome Coptidis and Radix Aucklandiae, has been used to treat gastrointestinal disease for many years. Berberine, jatrorrhizin, coptisine palmatine are four representative alkaloids in pill. Knowing that the drug disposal process vivo is closely related toxicity efficacy drug, it important classify properties these alkaloids. In this study, pharmacokinetics tissue distribution were investigated. The analytical samples analyzed using validated...
Chemical examination of the methanolic extract from stem bark Daphne feddei led to isolation three new dicoumarin glucosides (1-3), and eight known coumarins, dicoumarins glucosides. Their structures were elucidated by extensive analysis spectral data comparison with literature values. All compounds tested for inhibitory activity against lipopolysaccharide-induced NO production in RAW 264.7 macrophages, 4 5 showed potent IC₅₀ values 0.161 0.127 μM, respectively.
Mulberry extract from Fructus Mori contains an anthocyanin pigment and has been widely used as a food additive in China other Eastern Asian countries. Only few research done on toxicological profiling of mulberry for its safety evaluation; however, the data is inconclusive. In current study, 4200, 1400, or 466 mg/kg were orally administrated to Sprague Dawley rats 90 consecutive days followed by recovery period 28 days. No abnormalities detected body weights, intake, ophthalmological,...
Two new cyclohexyl-ethanol derivatives, incarvmareins A (1) and B (2), together with two known 3 4, were isolated from the ethanolic extract of roots Incarvillea mairei. The structures compounds elucidated primarily on basis analysis spectroscopic data.
Brigatinib and brigatinib-analog are potent selective ALK inhibitors with the similar structure. A simple sensitive high-performance liquid chromatography tandem mass spectrometry (LC-MS/MS) method for simultaneous determination of brigatinib in rat plasma brain homogenate was developed validated. Chromatographic separation carried out on an ODS column acetonitrile 0.1% formic acid water as mobile phase gradient elution at a flow rate 0.5 mL/min. Detections were performed using TSQ Quantum...
Abstract magnified image Phytochemical studies on the whole plant of Incarvillea delavayi resulted in isolation three new compounds, incarvilleaol ( 1 ), incarvillaldehyde 2 ) and 2‐(1,4‐dihydroxycyclohexyl)ethyl caffeate 3 ). Their structures were defined basis UV, IR, 1D‐ 2D‐NMR H, H‐COSY, DEPT, HSQC, HMBC), as well HR‐ESI‐MS analyses.
To investigate the effects of clobenpropit and histidine on reinstatement morphine-induced conditioned place preference (CPP) in rats.The persistence, extinction CPP were established.In group three different doses (2, 5 10 microg/rat, i.c.v.) administered 15 min after morphine (1 mg/kg, i.p.) was injected. In (100, 200, 500 mg/kg) given 1 h prior to treatment mg/kg i.p).The reinstated by priming injection morphine. Clobenpropit (5, microg/rat) significantly inhabited a dose compared with...
Background: The objective of this study was to evaluate the impact pharmaceutical care on knowledge, adherence, and efficacy hormone therapy in climacteric women participated multidisciplinary collaborative clinic, launched by Peking University First Hospital (Beijing, People's Republic China) 2012. Methods: A total 296 patients were recruited (intervention group n=150, control n=146). intervention visited clinic for their initial therapy, receiving individualized (PC), whereas only general...