A5009598629- Hepatitis C virus research
- Hepatitis B Virus Studies
- Amino Acid Enzymes and Metabolism
- Polyamine Metabolism and Applications
- interferon and immune responses
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
Southern Medical University
2023-2025
Nanfang Hospital
2023-2025
Hypoxia contributes to cancer progression through various molecular mechanisms and hepatocellular carcinoma (HCC) is one of the most hypoxic malignancies. Hypoxia-inducible gene domain protein-1a (HIGD1A) typically induced via epigenetic regulation promotes tumor cell survival during hypoxia. However, role HIGD1A in HCC remains unknown. expression was determined 24 pairs human samples para-tumorous tissues. Loss-of-function experiments were conducted both vivo vitro explore proliferation...
Abstract Hepatitis B Virus (HBV) replication has been reported to be restricted by the intrahepatic host restriction factors and antiviral signaling pathways. The intracellular mechanisms underlying significant viremia difference among different phases of natural history chronic HBV infection remain elusive. We herein report that hypoxia‐induced gene domain protein‐1a (HIGD1A) was highly expressed in liver inactive carriers with low viremia. Ectopic expression HIGD1A hepatocyte‐derived cells...