A5016279405- Neurotransmitter Receptor Influence on Behavior
- Effects of Radiation Exposure
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Spaceflight effects on biology
- Neuroscience and Neuropharmacology Research
- Radiation Therapy and Dosimetry
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Sleep and Work-Related Fatigue
- Cannabis and Cannabinoid Research
- Heart Rate Variability and Autonomic Control
- Olfactory and Sensory Function Studies
- Neuropeptides and Animal Physiology
- Anesthesia and Neurotoxicity Research
- Esophageal Cancer Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Bone health and osteoporosis research
- Sleep and related disorders
- Eicosanoids and Hypertension Pharmacology
- Tryptophan and brain disorders
- Nicotinic Acetylcholine Receptors Study
- Biochemical Analysis and Sensing Techniques
- Bone fractures and treatments
- Sleep and Wakefulness Research
Johns Hopkins University
2013-2024
Johns Hopkins Medicine
2013-2024
Uniformed Services University of the Health Sciences
2020-2024
Bristol-Myers Squibb (United States)
2024
Institute of Behavioral Sciences
2020-2021
Combat Capabilities Development Command Soldier Center
2020
Johns Hopkins Bayview Medical Center
2015
Behavioral Pharma (United States)
2014
American University
2007-2012
University of Washington
2010
To assess the possible neurobehavioral performance risks to astronauts from living in a space radiation environment during long-duration exploration missions, effects of head-only proton irradiation (150 MeV/n) at low levels (25-50 cGy, approximating an astronaut's exposure 2-year planetary mission) were examined adult male Long-Evans rats performing analog human psychomotor vigilance test (PVT). The rodent version PVT or rPVT tracks variables analogous PVT, including selective...
The current report assessed the effects of low-level proton irradiation in inbred adult male Fischer 344 and Lewis rats performing an analog human Psychomotor Vigilance Test (PVT), commonly utilized as object risk assessment tool to quantify fatigue sustained attention laboratory, clinical, operational settings. These strains were used determine if genetic differences dopaminergic function would impact radiation-induced deficits attention. Exposure head-only (25 or 100 cGy) disrupted rPVT...
Background: There are numerous botanical extracts and fractions that have been shown to a diverse range of bioactivities. Many nutraceutical products food supplements contain phytochemicals - often multiple numbers them as constituents single product. is paucity data on the net bioactivities these multi-component products. This paper reports effects four such expression six genes critical maintenance good health. Objectives: We investigated several number derived from plant species well...
To investigate the ability of a commercial extract from medicinal plant Artemisia annua to modulate production cytokine, tumor necrosis factor-alpha (TNF-α), and cyclooxygenase (COX) inflammatory marker, prostaglandin E2 (PGE2) in activated neutrophils.Neutrophils were harvested rat whole blood cultured presence or control samples. Neutrophils, except unactivated cells, with 10 μg/mL lipopolysaccharide (LPS). The cells range different concentrations A. extracts (400-1 μg/mL) artemisinin (200...
Future long-duration space missions will involve travel outside of the Earth's magnetosphere, which result in increased radiation exposure for astronauts. Exposure could permanently damage multiple tissues, including central nervous system (CNS), and deleterious effects on cognition behavior during beyond mission. Here, we assessed whole-body oxygen ion (16O; 1,000 MeV/n) (5 or 25 cGy) social odor recognition memory male Long-Evans rats at one six months after exposure. At month...
Future long-duration space missions will involve travel outside of the Earth’s magnetosphere protection and result in astronauts being exposed to high energy charge (HZE) ions protons. Exposure this type radiation can damage central nervous system deficits numerous cognitive domains that jeopardize mission success. Social processing is a domain important for people living working groups, such as astronauts, but it has received little attention terms HZE ion exposure. In current study, we...
The present report describes an animal model for examining the effects of radiation on a range neurocognitive functions in rodents that are similar to number basic human cognitive functions. Fourteen male Long-Evans rats were trained perform automated intra-dimensional set shifting task consisted their learning discrimination between two stimulus shapes followed by more complex stages (e.g., reversal, compound discrimination, new shape and reversal). One group was exposed head-only X-ray...
4044 Background: Q-TWiST analysis is an established methodology combining efficacy, safety, and quality of life (QoL) data into a single metric. Previous analyses among all randomized CM 649 patients with minimum 12 months’ follow-up demonstrated that nivolumab plus chemotherapy (NIVO+chemo) yielded mean gain 1.8 (95% CI 0.9-2.7) months, representing improved 12.8% relative gain, compared chemo alone (Lin et al, 2023). An updated using 4-yr trial may further inform treatment decisions for...
Abstract The systematic comparison between Fischer and Lewis rats is a popular animal model of genetic factors in drug abuse. Although environmental interact to affect abuse humans, analogous effects have not yet been reported within the Fischer–Lewis model. In order assess contributions interaction genotype early maternal environment on responses abuse, present study employed cross‐fostering design, where male female pups were reared by unrelated dams their own strain (in‐fostered) or other...