A5031935309- Effects of Radiation Exposure
- Radiation Therapy and Dosimetry
- Spaceflight effects on biology
- Genomics, phytochemicals, and oxidative stress
- Obsessive-Compulsive Spectrum Disorders
- Receptor Mechanisms and Signaling
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Cardiac Ischemia and Reperfusion
- Neurotransmitter Receptor Influence on Behavior
- Platelet Disorders and Treatments
- Mitochondrial Function and Pathology
- Calcium signaling and nucleotide metabolism
- Autophagy in Disease and Therapy
- Child and Adolescent Psychosocial and Emotional Development
- Biochemical effects in animals
- Cardiac Imaging and Diagnostics
- Cell death mechanisms and regulation
- Vitamin C and Antioxidants Research
- Eating Disorders and Behaviors
- Chemotherapy-induced cardiotoxicity and mitigation
- Pharmacological Effects of Medicinal Plants
- Autism Spectrum Disorder Research
- Thyroid Disorders and Treatments
- Curcumin's Biomedical Applications
- Redox biology and oxidative stress
Saraswati Dental College and Hospital
2024
Pushpawati Singhania Research Institute
2024
Rite Aid (United States)
2023
Indira Gandhi Delhi Technical University for Women
2023
University of Arkansas for Medical Sciences
2012-2022
Pt. Jawahar Lal Nehru Memorial Medical College
2018-2022
Jawaharlal Nehru University
2021
Maharaja Krishna Chandra Gajapati Medical College and Hospital
2020
Armed Forces Medical College
2020
Sriram Chandra Bhanja Medical College Hospital
2019
Age-associated mitochondrial dysfunction and oxidative damage are primary causes for multiple health problems including sarcopenia cardiovascular disease (CVD). Though the role of Nrf2, a transcription factor that regulates cytoprotective gene expression, in myopathy remains poorly defined, it has shown beneficial properties both CVD. Sulforaphane (SFN), natural compound Nrf2-related activator genes, provides protection several states CVD is various stages clinical trials, from cancer...
This paper aims to improve the ABC analysis method used for inventory management by applying Pythagorean Fuzzy TODIM approach. is one well-known and widely classification techniques which divides items into three categories according their importance value. However, traditional does not consider imprecision vagueness of real-world data, can lead inaccurate results poor decisions. The proposed approach enhances incorporating fuzzy numbers be considered in data. improved helps companies...
Space travel is associated with an exposure to low-dose rate ionizing radiation and the microgravity environment, both of which may lead impairments in cardiac function. We used a mouse model determine short- long-term effects simulated (hindlimb unloading; HU), continuous γ-irradiation, or combination HU γ-irradiation.Cardiac tissue was obtained from female, C57BL/6J mice 7 days, 1 month, 4 months, 9 months following completion 21 day γ-irradiation (average dose 0.01 cGy/h total 0.04 Gy),...
Glutathione S-transferase alpha 4 (GSTA4-4) is one of the enzymes responsible for removal 4-hydroxynonenal (4-HNE), an electrophilic product lipid peroxidation in cellular membranes during oxidative stress. 4-HNE a direct activator nuclear factor (erythroid-derived 2)-like 2 (Nrf2), transcription with many target genes encoding antioxidant and anti-electrophile enzymes. We have previously shown that Gsta4-null mice on 129/Sv background exhibited increased activity Nrf2 heart. Here we...
Abstract Hijacking of host metabolic status by a pathogen for its regulated dissemination from the is prerequisite propagation infection. M. tuberculosis secretes an NAD + -glycohydrolase, TNT, to induce necroptosis hydrolyzing Nicotinamide adenine dinucleotide (NAD ). Herein, we expressed TNT in macrophages and erythrocytes; cells malaria parasite respectively, found that it reduced levels thereby induced eryptosis resulting premature pathogen. Targeting or interferes with reduction...
Exposure of the heart to ionizing radiation can cause adverse myocardial remodeling. In small animal models, local irradiation causes persistent alterations in cardiac mitochondrial function and swelling. POLY-MVA is a dietary supplement that contains palladium lipoic acid complex targets I has been demonstrated have greater redox potential than alone. improves anti-oxidant enzyme activity aged rat heart. this study, we tested whether mitigate effects radiation. Adult male rats were exposed...
5-hydroxytryptamine (5-HT) reuptake inhibitors counteract the pro-thrombotic effect of elevated plasma 5-HT by down-regulating uptake rates platelets. Cocaine also down-regulates platelet but in contrast, platelets cocaine-injected mice show a much higher aggregation rate than control mice. To examine involvement cocaine-mediated aggregation, we studied function isolated from wild-type and transgenic, peripheral knock-out (TPH1-KO) cocaine-insensitive dopamine transporter knock (DAT-KI) In...
Accidental exposure to ionizing radiation may lead delayed effects of acute (DEARE) in many organ systems. Activated protein C (APC) is a known mitigator the syndrome. To examine role APC DEARE, we used transgenic mouse model with 2- 3-fold increased plasma levels (high APC, APCHi). Male and female APCHi mice wild-type littermates were exposed 9.5 Gy γ-rays their hind-legs (bone marrow) shielded from allow long-term survival. At 3 6 months after irradiation, cardiac function was measured...
Angiotensin II (Ang II) is a critical component of the reninangiotensin system that contributes to hypertension. Although platelets in blood from hypertensive subjects have an abnormal biological profile, it unclear if circulating Ang influences platelet aggregation or thrombus formation. One abnormalities presented during hypertension elevated plasma concentration serotonin (5-HT) caused by reduced 5-HT uptake secondary loss transporter (SERT) on membrane. In current study, we evaluated...
The majority of treatment research on obsessive-compulsive disorder (OCD) has focused emotional processing theory (EPT)-based exposure-based interventions. Despite the outcomes EPT-based exposure and response prevention (ERP), a sizeable percentage patients do not respond whereas 50%-60% those who experience at least partial relapse follow-up assessments. Inhibitory learning (ILT) provides novel foundation for understanding how therapy can be maximized to overcome such deficits but been...
Ischemic cardiomyopathy (ICM) and non-ICM (NICM) causes of dilated with similar clinical presentation have different management prognosis. This study employed myocardial perfusion imaging (MPI) to differentiate between the two using quantitative parameters in Indian population.Fifty patients prospectively underwent MPI 18F-fluorodeoxyglucose metabolism studies. P values (0.05 as significant) were calculated for left ventricular ejection fraction (EF), end diastolic volume (EDV) at rest...
Women consuming molecular iodine (I2) through seaweeds suffer the least from breast cancers. Zoledronate (Zol) is in clinical use for alleviation of bone pain cancer patients. Triple negative cancers exhibit high mortality due to lack neoadjuvant chemotherapy. I2 and Zol independently cause weak antiproliferative apoptotic effect. So far, their combined effects have not been tested. We analyzed effect combination with as a potent adjuvant therapeutic agent triple cells (MDA-MBA-231) mice...
Background Serotonin (5-HT) is a biogenic amine that also acts as mitogen and developmental signal early in rodent embryogenesis. Genetic pharmacological disruption of 5-HT signaling causes various diseases disorders via mediating central nervous system, cardiovascular serious abnormalities on growing embryo. Today, neither the effective modulators pathways nor genes affected by are well known yet. Methodology/Principal Findings In an attempt to identify altered pathways, we analyzed global...