A5062081692- Epigenetics and DNA Methylation
- Folate and B Vitamins Research
- Effects of Radiation Exposure
- Cancer Research and Treatments
- Radiation Therapy and Dosimetry
- RNA modifications and cancer
- Porphyrin Metabolism and Disorders
- Air Quality and Health Impacts
- Cancer, Hypoxia, and Metabolism
- Chromosomal and Genetic Variations
- DNA Repair Mechanisms
- Amino Acid Enzymes and Metabolism
- Carcinogens and Genotoxicity Assessment
- Metabolism and Genetic Disorders
- Phytoestrogen effects and research
- Spaceflight effects on biology
- Cancer-related Molecular Pathways
- Energy and Environment Impacts
- Gut microbiota and health
- Polyamine Metabolism and Applications
- Nanoplatforms for cancer theranostics
- Ferroptosis and cancer prognosis
- Radioactivity and Radon Measurements
- interferon and immune responses
- Cancer Cells and Metastasis
University of Arkansas for Medical Sciences
2015-2024
Arkansas Children's Nutrition Center
2013-2014
McGill University
2006-2012
McGill University Health Centre
2008-2009
Centre Hospitalier Universitaire de Grenoble
2009
Montreal General Hospital
2009
Extensive incorporation of engineered nanomaterials (ENMs) into industrial and biomedical applications increases the risks exposure to these potentially hazardous materials. While geno- cytotoxic effects ENMs have been investigated, potential target cellular epigenome remains largely unknown. Our goal was determine whether industry relevant can affect at low doses. A panel cells inhalation exposures such as human murine macrophages (THP-1 RAW264.7, respectively) small airway epithelial...
Xiaoyan Lua, Isabelle R. Miousseb, Sandra V. Pirelaa, Jodene K. Moorec, Stepan Melnykd, Igor Koturbashb* & Philip Demokritoua*a Center for Nanotechnology and Nanotoxicology, Department of Environmental Health, Harvard T. H. Chan School Public Boston, MA, USA, b Occupational College University Arkansas Medical Sciences, Little Rock, AR, c Systems Biology, School, d Pediatrics, USA
Engineered nanomaterials (ENMs) incorporated into toner formulations of printing equipment become airborne during consumer use. Although information on the complex physicochemical and toxicological properties both powders printer-emitted particles (PEPs) continues to grow, most studies have not used actual PEPs but rather primarily raw powders, which are representative current exposures experienced at level printing.We assessed biological responses a panel human cell lines PEPs.Three...
There is an increasing need to better understand the long-term health effects of high-linear energy transfer (LET) radiation due exposure during space missions, as well its use in clinical treatments. Previous studies have indicated that 56Fe heavy ions increases incidence acute myeloid leukemia (AML) mice but underlying molecular mechanisms remain elusive. Epigenetic alterations play a role radiation-induced genomic instability and initiation progression AML. In this study, we assessed...
Methionine, a central molecule in one-carbon metabolism, is an essential amino acid required for normal growth and development. Despite its importance to biological systems, methionine toxic when administered at supra-physiological levels. The aim of this study was investigate the effects short-term dietary modulation on proximal jejunum, section gut specifically responsible absorption, mouse model. Eight-week-old CBA/J male mice were fed methionine-adequate (MAD; 6.5 g/kg) or...
Dietary methionine restriction is associated with improved health outcomes and an increase in lifespan animal models. We have previously shown that dietary induces alteration the intestinal microbiome. The composition of microbiota a determinant we, therefore, hypothesized would also induce changes murine After one month on methionine-restricted diet, five-month-old male female C57BL/6 mice had decreased levels serum methionine, without body weight. identified decrease hepatic methylation...
The gastrointestinal (GI) system is highly susceptible to irradiation. Currently, there no Food and Drug Administration (FDA)-approved medical countermeasures for GI radiation injury. vitamin E analog gamma-tocotrienol (GT3) a promising radioprotector in mice nonhuman primates (NHP). We evaluated GT3-mediated recovery total-body irradiated (TBI) NHPs. Sixteen rhesus macaques were divided into two groups; eight received vehicle GT3 24 h prior 12 Gy TBI. Proximal jejunum was assessed...
Dietary methionine restriction (MR), defined as a reduction of intake by around 80%, has been shown to reproducibly decrease tumor growth and synergize with cancer therapies. In this study, we combined DMR immune checkpoint inhibitors (ICIs) in model colon adenocarcinoma. vitro, observed that MR increased the expression MHC-I PD-L1 both mouse human colorectal cells. We also saw an increase gene STING, known inducer type I interferon signaling. Inhibition cGAS–STING pathway, pharmacologically...
Respiratory mortality and morbidity has been associated with exposure to particulate matter (PM). Experimental evidence suggests involvement of cytotoxicity, oxidative stress, inflammation in the development PM‐associated pathological states; however, exact mechanisms remain unclear. In current study, we analyzed short‐term epigenetic response PM 10 (particles aerodynamic diameter less than μm) mouse ascitic RAW264.7 macrophages (BALB/C Abelson murine leukemia virus‐induced tumor). Ambient...
Despite significant progress, the long-term health effects of exposure to high charge (Z) and energy (E) nuclei (HZEs) underlying mechanisms remain poorly understood. Mouse studies show that space missions can result in pulmonary pathological states. The goal this study was evaluate pro-fibrotic pro-carcinogenic low doses heavy iron ions (56Fe) mouse lung. Exposure 56Fe (600 MeV; 0.1, 0.2 0.4 Gy) resulted minor changes, detected at beginning fibrotic phase (22 weeks post exposure), which...
Radiation exposure causes acute damage to hematopoietic and immune cells. To date, there are no radioprotectors available mitigate injury after radiation exposure. Gamma-tocotrienol (GT3) has demonstrated promising radioprotective efficacy in the mouse nonhuman primate (NHP) models. We determined GT3-mediated recovery total-body irradiated (TBI) NHPs. Sixteen rhesus macaques divided into two groups received either vehicle or GT3, 24 h prior TBI. Four animals each treatment group were exposed...