A5066289968- Neurotransmitter Receptor Influence on Behavior
- Cannabis and Cannabinoid Research
- Eating Disorders and Behaviors
- Neuroscience and Neuropharmacology Research
- Regulation of Appetite and Obesity
- Obsessive-Compulsive Spectrum Disorders
- Substance Abuse Treatment and Outcomes
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Forensic Toxicology and Drug Analysis
- Neuropeptides and Animal Physiology
- Pharmacological Receptor Mechanisms and Effects
- Impact of Technology on Adolescents
- Alcohol Consumption and Health Effects
- Gut microbiota and health
- Biochemical effects in animals
- Tryptophan and brain disorders
- Pharmacology and Obesity Treatment
- Obesity, Physical Activity, Diet
- Diet and metabolism studies
- Venous Thromboembolism Diagnosis and Management
- Evolutionary Psychology and Human Behavior
- Homelessness and Social Issues
- GABA and Rice Research
- Neuroendocrine regulation and behavior
Johns Hopkins University
2020-2024
Johns Hopkins Medicine
2021-2024
Centennial Medical Center
2023-2024
Behavioral Pharma (United States)
2023
Johns Hopkins Bayview Medical Center
2023
University of Baltimore
2023
Boston University
2014-2020
VA Boston Healthcare System
2015
University of Virginia
2013-2015
Kaiser Permanente
2001
Objective: This study examines the hypothesis that treatment reduces medical utilization and costs of patients with substance use problems. Method: Adult (N = 1.011; 67% men) entering outpatient chemical dependency recovery program at Sacramento Kaiser Permanente over a 2-year period were recruited into study. Medical examined for 18 months prior after intake. To account overall changes in cost, an age, gender length-of-enrollment matched nonpatient control group 4,925) was selected from...
Contexts associated with opioid reward trigger craving and relapse in addiction. Effects of reward-context associative learning on nucleus accumbens (NAc) dendritic morphology were studied using morphine conditioned place preference (CPP). Morphine-conditioned mice received saline 10 mg/kg subcutaneous (s.c.) alternate days. Saline-conditioned s.c. each day. saline-conditioned groups injections immediately before eight daily conditioning sessions. Morphine homecage controls had no CPP...
Impulsivity is a behavioral trait frequently seen in drug addicted individuals and who pathologically overeat. In this study, we hypothesized that high impulsivity precedes confers vulnerability for food addiction-like behavior. For purpose trained rats differential reinforcement of low rates responding (DRL) task to select high- low-impulsive rats. These then self-administered highly palatable diet (Palatable group) or regular chow (Chow 1h daily sessions, under increasing fixed ratio (FR)...
Introduction: Minor cannabinoids are increasingly being consumed in oral formulations (i.e., edibles, tinctures) for medical and nonmedical purposes. This study examined the pharmacokinetics (PKs) of tetrahydrocannabivarin (THCV), cannabichromene (CBC), cannabinol (CBN), delta-8-tetrahydrocannabinol (D8-THC) after first last dose during a 14-day administration period. Materials Methods: Sprague-Dawley rats (N=6 animals/dose, 50% female) were given an assigned one four (THCV=3.2–100 mg/kg,...
A well-documented side effect of cannabis and Δ9-tetrahydrocannabinol (THC) acute administration is deficits in cognition attention. Cannabidiol (CBD), a nonintoxicating constituent cannabis, may modulate THC's impairing effects. goal this study was to determine the effects THC CBD, alone combination, on performance rodent Psychomotor Vigilance Test (rPVT), translational paradigm used quantify sustained Outcome measures rPVT include motor speed, premature responding, lapses Sprague Dawley...
Abstract A relationship between the gut microbiome and alcohol use disorder has been suggested. Excessive produces changes in fecal metabolome both rodents humans. Yet, these can be observed only a subgroup of studied populations, reversal does not always occur after abstinence. We aimed to analyze microbial composition function translationally relevant baboon model chronic heavy drinking that also meets binge criteria (drinking too much, fast, often), i.e., ~1 g/kg blood levels (BALs) ≥...