A5102895132- Neurotransmitter Receptor Influence on Behavior
- Forensic Toxicology and Drug Analysis
- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Psychedelics and Drug Studies
- Pain Mechanisms and Treatments
- Nicotinic Acetylcholine Receptors Study
- Neuropeptides and Animal Physiology
- Tryptophan and brain disorders
- Smoking Behavior and Cessation
- Mental Health Research Topics
- Sleep and Wakefulness Research
- Alcohol Consumption and Health Effects
- Advanced Causal Inference Techniques
- Epigenetics and DNA Methylation
- Biochemical Analysis and Sensing Techniques
- Opioid Use Disorder Treatment
- Histone Deacetylase Inhibitors Research
- Pain Management and Placebo Effect
- Hormonal and reproductive studies
- Dye analysis and toxicity
- Memory and Neural Mechanisms
- Computational Drug Discovery Methods
- Statistical Methods and Bayesian Inference
University of California, San Diego
2020-2022
La Jolla Alcohol Research
2018-2021
Scripps Research Institute
2018-2019
University of California, Los Angeles
2019
Western Michigan University
2015-2017
University of North Carolina at Chapel Hill
2006
Psychopharmacology research has amassed substantial evidence for similarities between synthetic cathinones and other commonly abused psychostimulants. Few studies have utilized drug discrimination methods to investigate cathinones, the precise neurochemical substrates underlying their interoceptive effects not been examined. The present study assessed involvement of D1 D2 dopaminergic receptors in stimulus 3,4-methylenedioxypyrovalerone (MDPV) mephedrone (MEPH) rats trained discriminate...
Abstract Rationale Adolescents represent a vulnerable group due to increased experimentation with illicit substances that is often associated the adolescent period, and because drug use can result in long-term effects differ from those caused by initiated during adulthood. Objectives The purpose of present study was determine repeated heroin vapor inhalation adolescence on measures nociception, anxiety-like behavior adulthood female male Wistar rats. Methods Rats were exposed twice daily 30...
ABSTRACT The transition from recreational drug use to addiction involves pathological learning processes that support a persistent shift flexible, goal‐directed habit behavioral control. Here, we examined the molecular mechanisms supporting altered function in hippocampal (HPC) and dorsolateral striatum (DLS) memory systems following abstinence repeated cocaine. After 3 weeks of cocaine (experimenter‐ or self‐administered), tested new male rats using dual‐solution maze task, which provides...
Abstract Background Electronic nicotine delivery systems (ENDS, e-cigarettes) are increasingly used for the self-administration of by various human populations, including previously nonsmoking adolescents. Studies in preclinical models necessary to evaluate health impacts ENDS development addiction, effects vehicles, flavorants and co-administered psychoactive substances such as ∆ 9 -tetrahydrocannabinol (THC). This study was conducted validate a rat model useful delivered inhalation vapor...
Abstract Advances in drug vapor exposure systems utilizing e-cigarette technology have enabled evaluation of Δ-9-tetrahydrocannabinol (THC) effects laboratory animals. The purpose this study was to 1) establish a range parameters THC rats sufficient produce behavioral dose-effect curve battery tasks sensitive THC; 2) investigate sex differences the and injection (intraperitoneal, IP) on these behaviors two strains outbred rats. Male female Wistar Sprague Dawley (N=22, 5-6/group) received via...
Abstract Rationale Adolescents represent a vulnerable group due to increased experimentation with illicit substances that is often associated the adolescent period, and because drug use can result in long-term effects differ from those caused by initiated during adulthood. Objectives The purpose of present study was determine repeated heroin vapor inhalation adolescence on measures nociception, anxiety-like behavior adulthood female male Wistar rats. Methods Rats were exposed twice daily...
Abstract The synthetic cathinone α-pyrrolidinopentiophenone (α-PVP) has been associated with violent and/or bizarre public behavior in users. Association of such extended binges drug use motivates additional investigation, particularly since a prior study found that half male rats experience binge exceptionally high intake, followed by sustained lower levels self-administration during the acquisition intravenous (IVSA) closely related drug, 3,4-methylenedioxypyrovalerone. binge-like pattern...
Rationale Use of a diversity synthetic psychoactive cathinone drugs (“bathsalts”) continues to expand worldwide despite legal control. The pyrrolidinophenones, 3,4‐methylenedioxypyrovalerone (MDPV) and α‐pyrrolidinopentiophenone (α‐PVP), cause violent and/or bizarre public behavior in some users are potent reinforcers rodent intravenous self‐administration (IVSA) models. Other cathinones with entactogen‐like pharmacology appear be more efficacious than the class‐defining...
Although inhalation is a common route for the administration of illicit opioid drugs, there are only few animal studies on effects inhaled opioids. The present work aimed to assess behavioral repeated heroin vapor exposure during adolescence measures nociception, anxiety, and locomotor activity later in adulthood. To this end, adolescent female male Wistar rats were exposed 30 minutes twice daily 10 days starting PND 36. Upon reaching adulthood, warm-water tail-withdrawal tests performed...