A5020260480- Gut microbiota and health
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Immune Response and Inflammation
- Healthcare cost, quality, practices
- Microbial Community Ecology and Physiology
- COVID-19 and healthcare impacts
- Genomics and Phylogenetic Studies
- Effects of Radiation Exposure
- Spaceflight effects on biology
- Cytokine Signaling Pathways and Interactions
- Cancer Research and Treatments
- COVID-19 epidemiological studies
- Social Media in Health Education
- Estrogen and related hormone effects
- Inflammatory mediators and NSAID effects
- Cancer Immunotherapy and Biomarkers
- Tea Polyphenols and Effects
- Phytoestrogen effects and research
- Virology and Viral Diseases
- S100 Proteins and Annexins
- interferon and immune responses
- Stress Responses and Cortisol
- Gastrointestinal motility and disorders
- Immune cells in cancer
Johns Hopkins Medicine
2019-2022
Johns Hopkins University
2019-2022
University of Baltimore
2022
Fox Chase Cancer Center
2021
Lafayette College
2014-2017
Recent studies in cancer patients and animal models demonstrate that intestinal microbiota influence the therapeutic efficacy of treatments, including immune checkpoint inhibition. However, no to-date have investigated relationships between gastrointestinal composition response to inhibition advanced metastatic castrate resistant prostate (mCRPC). We performed 16S rRNA gene sequencing fecal DNA from 23 individuals with mCRPC progressing on enzalutamide just prior treatment anti-PD-1...
Short read 16 S rRNA amplicon sequencing is a common technique used in microbiome research. However, inaccuracies estimated bacterial community composition can occur due to amplification bias of the targeted hypervariable region. A potential solution sequence and assess multiple regions tandem, yet there currently no consensus as appropriate method for analyzing this data. Additionally, are many analysis resources data produced from Illumina platform, but fewer open-source options available...
Future long-duration space missions will involve travel outside of the Earth’s magnetosphere protection and result in astronauts being exposed to high energy charge (HZE) ions protons. Exposure this type radiation can damage central nervous system deficits numerous cognitive domains that jeopardize mission success. Social processing is a domain important for people living working groups, such as astronauts, but it has received little attention terms HZE ion exposure. In current study, we...
To determine whether there was a relationship between damage associated molecular pattern molecule (DAMP) expression and recruitment of suppressor cells to sites metastasis we measured relative DAMPs, regulatory T (Tregs), myeloid derived (MDSC) in mice at various stages breast cancer progression using the 4T1 model. Although S100A8 expressed relatively low levels tumor cells, 100-fold higher lung liver which are common for this tumor. Despite high level lungs naïve mice, increased further...
The public health crisis created by the COVID-19 pandemic has spurred a deluge of scientific research aimed at informing and medical response to pandemic. However, early in pandemic, those working frontline clinical care had insufficient time parse rapidly evolving evidence use it for decision-making. Academics medicine were well-placed translate clinicians practitioners. Novel Coronavirus Research Compendium (NCRC), group >60 faculty trainees across United States, formed March 2020 with...
Abstract The public health crisis created by the SARS-CoV-2 pandemic has spurred a deluge of scientific research aimed at informing and medical response to COVID-19 pandemic. However, those working in frontline clinical care had insufficient time parse rapidly evolving evidence use it for decision making. Academics medicine were well-placed translate clinicians practitioners. Novel Coronavirus Research Compendium (NCRC), group >50 faculty trainees, began March 2020 with goal quickly...
Abstract Short read 16S rRNA amplicon sequencing is a common technique used in microbiome research. However, inaccuracies estimated bacterial community composition can occur due to amplification bias of the targeted hypervariable region. A potential solution sequence and assess multiple regions tandem, yet there currently no consensus as appropriate method for analyzing this data. Additionally, are many analysis resources data produced from Illumina platform, but fewer open-source options...
Beyond low-Earth orbit, space radiation poses significant risks to astronaut health. Previous studies have shown that the microbial composition of gastrointestinal (GI) microbiome changes upon exposure high-linear energy transfer radiation. Interestingly, radiation-induced shifts in GI microbiota are linked various neuropsychological disorders. Herein, we aimed study and behaviors rats exposed whole-body (0, 5 or 25 cGy 4He, 250 MeV/n) at approximately 6 months age. Fecal samples were...
Abstract Previously we reported that murine mammary carcinoma and dendritic cells elicit distinct responses to Toll-like receptor (TLR) agonists. Here used a combination of computational biology molecular analysis identify the reason for responses. For this purpose created Netlogo model TLR4-Myd88 signaling pathway from TLR4 through nuclear translocation NF-kB culminating in CCL2 transcription. Assessing allowed us validate our by comparing how much was generated versus produced lab...
Abstract The gastrointestinal microbiome and the metabolites it can produce have been linked to response various cancer treatments, including in prostate cancer. Equol is a microbial metabolite that exclusively produced by conversion of soy isoflavones diet specific intestinal bacteria. Interestingly, equol has previously shown exhibit anti-androgen effects on cells likewise may act as radiosensitizer. We analyzed composition fecal samples collected from men receiving stereotactic ablative...