A5052640249- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Photochromic and Fluorescence Chemistry
- Alcoholism and Thiamine Deficiency
- Receptor Mechanisms and Signaling
- Birth, Development, and Health
- Nicotinic Acetylcholine Receptors Study
- Neurogenesis and neuroplasticity mechanisms
- Tryptophan and brain disorders
- Memory and Neural Mechanisms
- Maternal Mental Health During Pregnancy and Postpartum
- Epilepsy research and treatment
- Child and Adolescent Psychosocial and Emotional Development
- Neuroscience of respiration and sleep
- Functional Brain Connectivity Studies
- Prenatal Substance Exposure Effects
Yale University
2015-2025
New York State Psychiatric Institute
2013-2014
Significance Hippocampal hyperactivity predicts psychosis and may disrupt aspects of cognition in schizophrenia. Here, we use interneuron precursor transplants mice lacking cyclin D2 ( Ccnd2 ) to test links between hippocampal GABAergic interneurons psychosis-relevant phenotypes. -null show parvalbumin deficits increased vivo excitatory neuron spiking metabolic activity. This disinhibition is associated with cognitive excess dopamine Transplanting progenitors derived from the embryonic...
GABAA receptor (GABAAR) pentamers are assembled from a pool of 19 subunits, and variety in subunit combinations diversifies GABAAR functions to tune brain activity. Pentamers with distinct compositions localize differentially at synaptic non-synaptic sites mediate phasic tonic inhibition, respectively. Despite multitudes theoretical permutations, limited have been identified the brain. Currently, no molecular model exists for combinatorial assembly vivo. Here, we reveal rules native...