A5045265531- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Circadian rhythm and melatonin
- Adipose Tissue and Metabolism
- Neurobiology and Insect Physiology Research
- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Sleep and Wakefulness Research
- Photoreceptor and optogenetics research
- Pancreatic function and diabetes
- Neurotransmitter Receptor Influence on Behavior
- Insect and Arachnid Ecology and Behavior
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Neuroscience of respiration and sleep
- Insect Utilization and Effects
- Diet and metabolism studies
- Olfactory and Sensory Function Studies
- Invertebrate Immune Response Mechanisms
- Animal Behavior and Reproduction
- Stress Responses and Cortisol
- Neural dynamics and brain function
- Eating Disorders and Behaviors
- Advanced Chemical Sensor Technologies
- Memory and Neural Mechanisms
National Institutes of Health
2015-2024
National Institute of Diabetes and Digestive and Kidney Diseases
2015-2024
National Institute on Drug Abuse
2015-2024
University of Washington
2017
Beth Israel Deaconess Medical Center
2011-2016
Harvard University
2009-2016
Diabetes Australia
2014
Harvard University Press
2014
University of Massachusetts Chan Medical School
2006-2012
Several different neuronal populations are involved in regulating energy homeostasis. Among these, agouti-related protein (AgRP) neurons thought to promote feeding and weight gain; however, the evidence supporting this view is incomplete. Using designer receptors exclusively activated by drugs (DREADD) technology provide specific reversible regulation of activity mice, we have demonstrated that acute activation AgRP rapidly dramatically induces feeding, reduces expenditure, ultimately...
The nucleus accumbens (NAc) and the dynorphinergic system are widely implicated in motivated behaviors. Prior studies have shown that activation of dynorphin-kappa opioid receptor (KOR) leads to aversive, dysphoria-like behavior. However, endogenous sources dynorphin these circuits remain unknown. We investigated whether neuronal firing NAc is sufficient induce aversive found photostimulation cells ventral shell elicits robust conditioned real-time behavior via KOR activation, contrast,...
In Drosophila , formation of aversive olfactory long-term memory (LTM) requires multiple training sessions pairing odor and electric shock punishment with rest intervals. contrast, here we show that a single 2 min session more ethologically relevant sugar reinforcement forms appetitive lasts for days. Appetitive LTM has some mechanistic similarity to in it can be disrupted by cycloheximide, the dCreb2-b transcriptional repressor, crammer tequila LTM-specific mutations. However, is completely...
Significance Both in rodents and humans, melanocortin-4 receptors (MC4Rs) suppress appetite prevent obesity. Unfortunately, the underlying neural mechanisms by which MC4Rs regulate food intake are poorly understood. Unraveling these may open up avenues for treating In present study we have established that on neurons paraventricular nucleus of hypothalamus both necessary sufficient MC4R control feeding glutamatergic not GABAergic do express neuropeptides oxytocin, corticotropin-releasing...
Chemogenetic tools such as designer receptors exclusively activated by drugs (DREADDs) are routinely used to modulate neuronal and non-neuronal signaling activity in a relatively noninvasive manner. The first generation of DREADDs were templated from the human muscarinic acetylcholine receptor family insensitive endogenous agonist but instead clozapine-N-oxide (CNO). Despite undisputed success CNO an activator DREADDs, it has been known for some time that is subject low rate metabolic...