A5055397100- Stress Responses and Cortisol
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Regulation of Appetite and Obesity
- Inorganic Chemistry and Materials
- Tryptophan and brain disorders
- Adipose Tissue and Metabolism
- Sleep and Wakefulness Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Chemical Synthesis and Characterization
- Pain Mechanisms and Treatments
- Circadian rhythm and melatonin
- Estrogen and related hormone effects
- Photochromic and Fluorescence Chemistry
- Semiconductor materials and interfaces
- Chemical synthesis and alkaloids
- Eating Disorders and Behaviors
- Ferroelectric and Negative Capacitance Devices
- Alcohol Consumption and Health Effects
University of North Carolina at Chapel Hill
2011-2024
Cornell University
2017-2024
Weill Cornell Medicine
2017-2024
Louisiana State University Health Sciences Center New Orleans
2024
Indiana University School of Medicine
2012-2016
University of North Carolina Health Care
2016
National Institute of Mental Health
2015
Duke University
2008-2011
A well established body of work indicates a crucial role for corticotropin-releasing factor (CRF) in neurobiological responses associated with excessive dependence-like ethanol drinking ethanol-vapor-exposed rodents. Recent evidence demonstrates CRF the modulation binge-like consumption by nondependent mice, behavior that can precede dependence. The circuitry is engaged exposure, however, unknown. Using converging approaches, we provide that, similar to ethanol-vapor-induced increases...
Abstract Bed nucleus of the stria terminalis (BNST) neurons that synthesize corticotropin-releasing factor (CRF) drive binge alcohol drinking and anxiety. Here, we found female C57BL/6J mice drink more than males have greater basal BNST CRF neuron excitability synaptic excitation. We identified a dense VGLUT2 + input from paraventricular thalamus (PVT) releases glutamate directly onto but also engages large interneuron population to ultimately inhibit neurons, this polysynaptic PVT -BNST...
Abstract Addictions, including alcohol use disorders, are characterized by the loss of control over drug seeking and consumption, but neural circuits signaling mechanisms responsible for transition from controlled to uncontrolled abuse remain incompletely understood. Prior studies have shown that ‘compulsive‐like’ behaviors in rodents, example, persistent responding ethanol (EtOH) despite punishment, increased after chronic exposure EtOH. The main goal current study was assess effects...
Chronic stress during the developmental period of adolescence increases susceptibility to many neuropsychiatric diseases in adulthood, including anxiety, affective, and alcohol/substance use disorders. Preclinical rodent models adolescent have produced varying results that are species, strain, sex, laboratory-dependent. However, social isolation is a potent stressor humans has been reliably modeled male rats, increasing adult anxiety-like alcohol drinking behaviors, among others. In this...
Binge alcohol drinking is a risk factor linked to numerous disease states including use disorder (AUD). While men binge drink more than women, this demographic gap quickly shrinking, and preclinical studies demonstrate that females consistently consume males. Further, women are at increased for the co-expression of AUD with neuropsychiatric diseases such as anxiety mood disorders. However, little understood about chronic voluntary its long-term effects on behavior. Here, we sought...
Adverse prenatal environment is a risk factor for the development of psychiatric disorders. Although studies have implicated epigenetic mechanisms, little known about how epigenomic changes come and lead to abnormal behaviors in affected individuals. We sought identify transcriptomic signatures induced by proinflammatory gestational ventral dentate gyrus (vDG), hippocampal region linked avoidance threatening contexts, that persist promote anxiety-like behavior mice. Here we show adversity...
Alterations in hypothalamic–pituitary–adrenal axis function contribute to many of the adverse behavioral effects chronic voluntary alcohol drinking, including dependence and mood disorders; limbic brain structures such as bed nucleus stria terminalis (BNST) may be key sites for these effects. Here, we measured circulating levels several steroid hormones performed whole-cell electrophysiological recordings from acutely prepared BNST slices male rhesus monkeys allowed self-administer 12 months...
Abstract Ovarian-derived estrogen can signal non-canonically at membrane-associated receptors in the brain to rapidly regulate neuronal function. Early alcohol drinking confers greater risk for use disorder women than men, and binge is correlated with high levels, but a causal role driving has not been established. We found that female mice displayed reduced avoidance when was during estrous cycle it low. The pro-drinking, anxiolytic, effect of endogenous occurred via rapid signaling...