A5008026883- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Tryptophan and brain disorders
- Neural dynamics and brain function
- Treatment of Major Depression
- Visual perception and processing mechanisms
- Neuroendocrine regulation and behavior
- Tactile and Sensory Interactions
- Crop Yield and Soil Fertility
- Adipose Tissue and Metabolism
- Wheat and Barley Genetics and Pathology
- Neuropeptides and Animal Physiology
- Cancer, Stress, Anesthesia, and Immune Response
- Neurological disorders and treatments
- Circadian rhythm and melatonin
- Neural and Behavioral Psychology Studies
- Plant Disease Management Techniques
- Philosophy and Theoretical Science
- Neuroscience and Neural Engineering
- Functional Brain Connectivity Studies
- Nicotinic Acetylcholine Receptors Study
- Diet and metabolism studies
Advanced Process Combinatorics (United States)
2025
Purdue University West Lafayette
1989-2024
University of Michigan
2018-2022
Michigan Medicine
2021
Texas A&M University
2013-2019
Michigan United
2019
National Institutes of Health
2009-2014
Johns Hopkins University
2000-2013
Kennedy Krieger Institute
2007-2012
National Institute on Alcohol Abuse and Alcoholism
2009-2012
THE following report is an analysis of 28 cancers the thyroid seen in children between ages 4 and 18 years at Memorial Hospital. They constitute 6.5 per cent 430 Hospital during sixteen-year period 1932 1948. The purposes this are threefold: To discuss histologic types metastasizing properties that we have studied. possible etiologic factors as suggested from environmental, familial, other biologic recorded histories these patients. emphasize importance considering cancer differential...
Stress is a major risk factor for numerous neuropsychiatric diseases. However, susceptibility to stress and the qualitative nature of effects on behavior differ markedly among individuals. This partly because moderating influence genetic factors. Inbred mouse strains provide relatively stable restricted range environmental variability that valuable disentangling gene–stress interactions. Here, we screened panel inbred anxiety- depression-related phenotypes at baseline (trait) after exposure...
Significance Posttraumatic stress disorder is characterized by a resistance to extinction learning and dysregulated signaling of the neurotransmitter norepinephrine. Previous research suggested prelimbic infralimbic subdivisions medial prefrontal cortex (mPFC) regulate fear expression suppression, respectively. However, noradrenergic in response psychological may disrupt mPFC function, contributing deficits. Here we show, for first time our knowledge, that footshock dysregulates spike...
Major depression is a stress-linked disease with significant morbidity and the anesthetic drug ketamine of growing interest in treatment depression, since responsive individuals single dose has rapid (within hours) antidepressant effects that can be sustained for over week some instances. This combination fast action therapeutic effect lasts far beyond drug's half-life points to unique mechanism action. In this reverse translational study, we investigate degree which counteracts...
The detailed functional organization of the macaque second somatosensory cortex (SII) is not well understood. Here we report results a study SII hand region that combines microelectrode mapping using hand-held stimuli with single-unit recordings motorized, computer-controlled tactile oriented bar. data indicate extends approximately 10 mm in anteroposterior (AP) dimension, primarily within upper bank lateral sulcus. Furthermore, find evidence this consists multiple fields, central field...
Brain-derived neurotrophic factor (BDNF) is of interest because its putative role in stress and psychiatric disorders. Maternal separation used as an animal model early-life irritable bowel syndrome (IBS). Animals exposed to the paradigm show altered gut function together with heightened levels arousal corticosterone. Some probiotic organisms have been shown be benefit IBS influence brain-gut axis. Our objective was investigate effects maternal on BDNF under basal conditions response...
Orientation tuning has been studied extensively in the visual system, but little is known about it somatosensory system. Here we investigate second (SII) region using a motorized stimulator that presented small oriented bar to 12 finger pads of digits 2-5 (D2-D5) macaque monkey. A subset (23%; n = 218) 928 SII neurons [the same by Fitzgerald et al. (2004, 2006)] exhibited tuning, and most these were tuned on one or two pads. All eight 22.5 degrees separated orientations represented as...
The detailed structure of multidigit receptive fields (RFs) in somatosensory cortical areas such as the SII region has not been investigated previously using systematically controlled stimuli. Recently (Fitzgerald et al., 2004), we showed that comprises three adjoining fields: posterior, central, and anterior. Here characterize RF structures 928 neurons were reported study a motorized oriented bar was indented into 12 finger pads digits 2–5. Most (81%) responsive to stimuli, 81% those had...
We recognize, understand, and interact with objects through both vision touch. Conceivably, these two sensory systems encode object shape in similar ways, which could facilitate cross-modal communication. To test this idea, we studied single neurons macaque monkey intermediate visual (area V4) somatosensory SII) cortex, using matched stimuli. found patterns of sensitivity characterized by tuning for curvature direction. These parallel imply analogous coding mechanisms cortex.
Glutamatergic dysfunction is strongly implicated in schizophrenia and mood disorders. GluA1 knockout (KO) mice display schizophrenia- depression-related abnormalities. Here, we asked whether KO show mania-related were tested for behavior approach/avoid conflict tests, responses to repeated forced swim exposure, locomotor under stress after psychostimulant treatment. The effects of rapid dopamine depletion treatment with lithium or a GSK-3β inhibitor (SB216763) on hyperactivity tested....
The medial prefrontal cortex (mPFC) plays an essential role in regulating emotion, including inhibiting fear when danger has passed. extinction of fear, however, is labile and a number factors, stress, cause extinguished to relapse. Here we show that relapse rats limits single-unit activity among infralimbic (IL) neurons, which are critical for responses, facilitates prelimbic (PL) neurons involved expression. Pharmacogenetic activation noradrenergic the locus coeruleus mimics this shift...