A5045294279- Tactile and Sensory Interactions
- Multisensory perception and integration
- Visual perception and processing mechanisms
- Neural dynamics and brain function
- Transcranial Magnetic Stimulation Studies
- Color perception and design
- EEG and Brain-Computer Interfaces
- Motor Control and Adaptation
- Functional Brain Connectivity Studies
- Financial Markets and Investment Strategies
- Stock Market Forecasting Methods
- Neuroscience and Music Perception
- Advanced MRI Techniques and Applications
- Housing Market and Economics
- Pain Management and Treatment
- Prostate Cancer Treatment and Research
- Child Nutrition and Water Access
- Poverty, Education, and Child Welfare
- Prostate Cancer Diagnosis and Treatment
- Neuroscience and Neural Engineering
- Angiogenesis and VEGF in Cancer
- Stroke Rehabilitation and Recovery
- Neural and Behavioral Psychology Studies
- Olfactory and Sensory Function Studies
- Global Maternal and Child Health
Baylor College of Medicine
2015-2025
Shirley Ryan AbilityLab
2025
Johns Hopkins University
2006-2022
University of California, Berkeley
2019-2020
Baylor University
2018
Johns Hopkins Medicine
2009-2014
Allen Institute for Brain Science
2009-2013
Kennedy Krieger Institute
2008
Federal Trade Commission
2006
University of North Carolina at Chapel Hill
2004-2005
In this study we investigate the haptic perception of object size. We report results from four psychophysical experiments. first, ask subjects to discriminate size objects that vary in surface curvature and compliance while changing contact force. show exhibit constancy such using haptics does not change with changes Based on these results, hypothesize depends degree spread between digits at initial objects. second experiment, test hypothesis by having continuously an dynamically takes into...
We recognize, understand, and interact with objects through both vision touch. Conceivably, these two sensory systems encode object shape in similar ways, which could facilitate cross-modal communication. To test this idea, we studied single neurons macaque monkey intermediate visual (area V4) somatosensory SII) cortex, using matched stimuli. found patterns of sensitivity characterized by tuning for curvature direction. These parallel imply analogous coding mechanisms cortex.
We have previously analyzed shape processing dynamics in macaque monkey posterior inferotemporal cortex (PIT). described how early PIT responses to individual contour fragments evolve into tuning for multifragment configurations. Here, we curvature area V4, which provides feedforward inputs PIT. contrasted 2 hypotheses: 1) that V4 evolves from simpler elements, analogous synthesis and 2) emerges immediately, based on purely mechanisms. Our results clearly supported the first hypothesis....
Recent studies have challenged the traditional notion of modality-dedicated cortical systems by showing that audition and touch evoke responses in same sensory brain regions. While much this work has focused on somatosensory auditory regions, fewer investigated sound representations In functional magnetic resonance imaging (fMRI) study, we measured BOLD signal changes participants performing an frequency discrimination task characterized activation patterns related to stimulus using both...
The response of the prostate tissue microenvironment to androgen deprivation (AD) represents a critical component in treatment benign prostatic hyperplasia and cancer (CaP). Primary xenografts human CaP transplanted immunocompromized SCID mice were used characterize vasculature during initial 14 days AD. Microvessel density vascular lumen diameter decreased rapidly after AD, reached nadir on 2-4, recovered between 4 14. number apoptotic endothelial cells peaked day 2 AD precastration levels...
Tactile shape information is elaborated in a cortical hierarchy spanning primary (SI) and secondary somatosensory cortex (SII). Indeed, SI neurons areas 3b 1 encode simple contour features such as small oriented bars edges, whereas higher order SII represent large curved angles arcs. However, neural coding of these has not been systematically characterized area 2, the most caudal subdivision postcentral gyrus. In present study, we analyzed 2 responses to embossed fragments establish whether...
Our ability to process temporal frequency information by touch underlies our capacity perceive and discriminate surface textures. Auditory signals, which also provide extensive information, can systematically alter the perception of vibrations on hand. How auditory signals shape tactile processing is unclear; perceptual interactions between contemporaneous sounds are consistent with multiple neural mechanisms. Here we used a crossmodal adaptation paradigm, separated stimulation in time, test...
Somatosensory inputs are critical to motor control. Animal studies have shown that primary somatosensory lesions cause sensorimotor deficits along with disrupted organization in cortex (M1). How does damage (S1) influence networks humans? Using fMRI, we examined two individuals extensive left cortex, but primarily intact and preserved abilities. Given S1 damage, tactile detection localization were impaired for the contralesional hand both individuals. When moving hand, LS, near complete...
This research investigated the issue of weighting and number Twenty Statements Test (TST) responses with samples 165 Hong Kong secondary school pupils 100 Swedish Ethiopian university students. Responses were classified into idiocentric, large group, small allocentric categories, scores weighted by rank order response 7, 10, or 20 items considered. Analysis found that made a difference to proportions assigned these categories for but not other little testing hypotheses about gender cultural...
A major goal in perceptual neuroscience is to understand how signals from different sensory modalities are combined produce stable and coherent representations. We previously investigated interactions between audition touch, motivated by the fact that both sensitive environmental oscillations. In our earlier study, we characterized effect of auditory distractors on tactile frequency intensity perception. Here, describe converse experiments examining processing. Because two studies employ...
Working memory (WM) involves the ability to maintain and manipulate information held in mind. Neuroimaging studies have shown that secondary motor areas activate during WM for verbal content (e.g., words or letters), absence of primary area activation. This activation pattern may reflect an inner speech mechanism supporting online phonological rehearsal. Here, we examined causal relationship between system activity processing by using transcranial magnetic stimulation (TMS) We tested...
Recent advances in extended reality (XR) technologies make seeing and hearing virtual objects commonplace, yet strategies for synthesizing haptic interactions with continue to be limited. Two design principles govern the rendering of believable intuitive feedback: movement through open space must feel “free” while contact stiff. Herein, a novel multisensory approach that conveys proprioception effort illusory visual feedback refers wrist, via bracelet interface, discrete continuous...
Abstract Transgenic spontaneously occurring and transplantable xenograft models of adenocarcinoma the prostate (CaP) are established tools for study CaP progression metastasis. However, no animal model has been characterized that recapitulates response human vascular compartment to evolving tumor microenvironment during progression. We report primary xenografts noninvolved areas peripheral zone transplanted athymic nude mice provide a unique angiogenesis in an intact tissue microenvironment....
During haptic exploration of surfaces, complex mechanical oscillations – surface displacement and air pressure are generated, which then transduced by receptors in the skin inner ear. Tactile auditory signals thus convey redundant information about texture, partially carried spectral content these signals. It is no surprise, then, that representation temporal frequency linked somatosensory systems. An emergent hypothesis there exists a supramodal frequency, extension texture.
Our ability to perceive and discriminate textures is based on the processing of high-frequency vibrations generated fingertip as it scans across a surface. Although much known about vibration amplitude frequency information when cutaneous stimulation experienced at single location body, how these stimulus features are processed touch occurs multiple locations poorly understood. We evaluated participants' tactile cues (100-300 Hz) one hand while they ignored distractor their other hand....
Sensory information is represented and elaborated in hierarchical cortical systems that are thought to be dedicated individual sensory modalities. This traditional view of cortex organization has been challenged by recent evidence multimodal responses primary association areas. Although it indisputable areas respond multiple modalities, remains unclear whether these reflect selective processing for particular stimulus features. Here, we used fMRI adaptation identify brain regions sensitive...
People perceive spatial form and temporal frequency through touch. Although distinct somatosensory neurons represent information, these neural populations are intermixed throughout the system. Here, we show that touch can be dissociated separately enhanced via cortical pathways normally associated with vision audition. In Experiments 1 2, found anodal transcranial direct current stimulation (tDCS) applied over visual cortex, but not auditory enhances tactile perception of orientation. 3 4,...