A5011905263- Transcranial Magnetic Stimulation Studies
- Cardiomyopathy and Myosin Studies
- Prostate Cancer Treatment and Research
- Cardiac Fibrosis and Remodeling
- Viral Infections and Immunology Research
- Mobile Health and mHealth Applications
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Diabetes Management and Research
- Maternal and Perinatal Health Interventions
- Immunotherapy and Immune Responses
- Atherosclerosis and Cardiovascular Diseases
- Neuroscience and Neural Engineering
- Reproductive Health and Contraception
- RNA modifications and cancer
- Musculoskeletal Disorders and Rehabilitation
- Ubiquitin and proteasome pathways
- Tissue Engineering and Regenerative Medicine
- Transplantation: Methods and Outcomes
- Maternal and fetal healthcare
- Cell death mechanisms and regulation
- Sirtuins and Resveratrol in Medicine
- Chronic Disease Management Strategies
- Muscle Physiology and Disorders
Université de Bretagne Occidentale
2024
Centre Hospitalier Régional Universitaire de Brest
2024
Inserm
2024
The University of Melbourne
2024
The University of Sydney
2004-2023
Houston Methodist
2018-2022
Methodist Hospital
2020-2022
New England College of Optometry
2020
Texas A&M University – Kingsville
2019
New York University
2018
// Guangxin Zhang 1 , Chao Wang 2, 3 Mei Sun 4 Jindong Li Bin Chengyan Jin Peiyan Hua Ge Song Yifan Lisa L.H. Nguyen 2 Ranji Cui 5 Runhua Liu Lizhong Xingyi Department of Thoracic Surgery, Second Hospital Jilin University, Changchun, P.R. China Genetics, University Alabama at Birmingham, Alabama, USA Integrative Endemic Area, Tongji Huazhong Science and Technology, Wuhan, Pathology, Provincial Key Laboratory on Molecular Chemical Genetic, Correspondence to: Zhang, email: xingyizhang@live.com...
Abstract Purpose: In prostate cancer cells, there is CD24-dependent inactivation of mutant p53, but the mechanism and its significance remain largely unknown. Here, we validated this observation explored therapeutic potential targeting CD24 in TP53 cells. Experimental Design: Overall, 553 cancers (522 formalin-fixed paraffin-embedded 31 frozen tissues) were assessed for protein or mRNA expression TP53. The effects on p53-dependent transcriptional regulation, cell growth, cycle, apoptosis,...
Shifts in myosin heavy chain (MHC) expression within skeletal muscle can be induced by a host of stimuli including, but not limited to, physical activity, alterations neural aging, and diet or obesity. Here, we hypothesized that both age long-term (2 year) high fat/high sugar (HFS) would induce slow to fast MHC shift the plantaris, soleus, extensor digitorum longus (EDL) muscles from rhesus monkeys. Furthermore, tested whether supplementation with resveratrol, naturally occurring compound...
Alternating electric field therapy has been approved for glioblastoma (GBM). We have preclinical evidence anticancer effects in GBM cell cultures and mouse xenografts with an oscillating magnetic (OMF) generating device. Here we report OMF treatment of end-stage recurrent a 53-year-old man who had undergone radical surgical excision chemoradiotherapy, experimental gene left frontal tumor. He experienced tumor recurrence progressive enlargement leptomeningeal involvement. 5 weeks was well...
Background: The Mobile Insulin Titration Intervention (MITI) program helps patients with type 2 diabetes find their correct basal insulin dose without in-person care. Requiring only basic cell phone technology (text messages and calls), MITI is highly accessible to receiving care in safety-net settings. was shown a randomized controlled trial (RCT) be efficacious at New York City (NYC) clinic where often have challenges coming for In 2016, implemented as usual Bellevue Hospital (the site of...
In Brief Objective To compare the efficacy of intravaginal misoprostol tablets with transcervical Foley catheter for preinduction cervical ripening. Methods Pregnant women who presented induction labor unfavorable cervices (Bishop score less than 6) were assigned randomly to (50 μg tablet every 4 hours a maximum six doses) or 30-mL placed transcervically maintenance traction. Results Among 111 women, 53 allocated and 58 bulb. Contractile abnormalities more frequent in group (20.4%) (0%) (P <...
Tissue MicroArrays (TMAs) are a versatile tool for high-throughput protein screening, allowing qualitative analysis of large number samples on single slide. We have developed customizable TMA system that uniquely utilizes cryopreserved human cardiac from both heart failure and donor patients to produce formalin-fixed paraffin-embedded sections. Confirmatory upstream or downstream molecular studies can then be performed the same (biobanked) tissue. In pilot study, we applied our TMAs screen...
Microparticles circulate in plasma and have recently emerged as potential inflammatory markers cardiovascular disease. They are fragments of cell membranes that express cluster differentiation (CD) antigens present at elevated levels patients with acute coronary syndrome. We developed a novel method for the rapid detection microparticles using fluorescence-based antibody array system. Isolated captured on anti-CD spots immobilized nitrocellulose membrane. These CD antibodies directed against...
Cardiopulmonary bypass (CPB) is essential in heart transplantation surgery. It also used coronary artery grafting surgery where it has been associated with a postoperative inflammatory response. This manifests as an increase pro-inflammatory proteins like interleukin-8 and tumour necrosis factor alpha accompanied by increases neutrophil populations increased expression of cluster differentiation (CD) antigens. The latter have investigated using flow cytometry, which limited to the...
<title>Abstract</title> Myocardial infarction (MI) is a leading cause of death worldwide and can eliminate up to third the cardiomyocytes (CMs) within heart. Several non-human mammalian models limited number human heart studies suggest that CMs proliferate during early development, but most stop regenerating soon after birth. In contrast, rodent MI show increase their regenerative capacity in response ischemia, however this has not been shown humans. Using immunostaining, multi-omics unique...
We recently reported shrinkage of untreatable recurrent glioblastoma (GBM) in an end-stage patient using noninvasive brain stimulation with a spinning oscillating magnetic field (sOMF)-generating device called the Oncomagnetic device. Our vitro experiments demonstrated selective cancer cell death while sparing normal cells by sOMF-induced increase intracellular reactive oxygen species (ROS) levels due to perturbation mitochondrial electron transport. Here, we describe results vivo study...
<p>Figure S1: (Overexpression of CD24 mRNA in human PCa tissue based on analysis three datasets); Figure S2: (Nuclear and p53 staining cases); S3: (The sequence-specific DNA binding sites its target genes); S4: (CD24-dependent inactivation mutant cell cycle arrast LNCaP cells).</p>
<p>Figure S1: (Overexpression of CD24 mRNA in human PCa tissue based on analysis three datasets); Figure S2: (Nuclear and p53 staining cases); S3: (The sequence-specific DNA binding sites its target genes); S4: (CD24-dependent inactivation mutant cell cycle arrast LNCaP cells).</p>
<div>Abstract<p><b>Purpose:</b> In prostate cancer cells, there is CD24-dependent inactivation of mutant p53, but the mechanism and its significance remain largely unknown. Here, we validated this observation explored therapeutic potential targeting <i>CD24</i> in <i>TP53</i> cells.</p><p><b>Experimental Design:</b> Overall, 553 cancers (522 formalin-fixed paraffin-embedded 31 frozen tissues) were assessed for protein or...
<div>Abstract<p><b>Purpose:</b> In prostate cancer cells, there is CD24-dependent inactivation of mutant p53, but the mechanism and its significance remain largely unknown. Here, we validated this observation explored therapeutic potential targeting <i>CD24</i> in <i>TP53</i> cells.</p><p><b>Experimental Design:</b> Overall, 553 cancers (522 formalin-fixed paraffin-embedded 31 frozen tissues) were assessed for protein or...