A5078307830- Granular flow and fluidized beds
- Mineral Processing and Grinding
- Cyclone Separators and Fluid Dynamics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cannabis and Cannabinoid Research
- Particle Dynamics in Fluid Flows
- Drug Transport and Resistance Mechanisms
- Nitric Oxide and Endothelin Effects
- Amino Acid Enzymes and Metabolism
- Pharmacogenetics and Drug Metabolism
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Migraine and Headache Studies
- Analytical Methods in Pharmaceuticals
- Neonatal Health and Biochemistry
- Heme Oxygenase-1 and Carbon Monoxide
- Pregnancy and preeclampsia studies
- Antioxidant Activity and Oxidative Stress
- Vitamin C and Antioxidants Research
- Iron and Steelmaking Processes
- Muscle and Compartmental Disorders
- Mining and Gasification Technologies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cholesterol and Lipid Metabolism
- Combustion and flame dynamics
- Cancer, Lipids, and Metabolism
The Heart Research Institute
2023-2024
The University of Sydney
2014-2024
Robert Bosch (Australia)
2008-2020
Victor Chang Cardiac Research Institute
2020
Nanjing Brain Hospital
2014-2019
Nanjing Medical University
2014-2019
Monash University
1997-2008
Rensselaer Polytechnic Institute
2008
Delft University of Technology
2008
UNSW Sydney
2003-2008
We conducted transcardiac blood sampling in healthy subjects and with heart failure preserved ejection fraction (HFpEF) to compare cardiac metabolite lipid substrate use. demonstrate that fatty acids are less used by HFpEF hearts extraction is influenced hemodynamic factors including pulmonary pressures index. The release of many products protein catabolism apparent compared myocardium. In subgroup analyses, differences energy use between female male were identified.
The heme enzyme indoleamine 2,3-dioxygenase (IDO) is a key regulator of immune responses through catalyzing l-tryptophan (l-Trp) oxidation. Here, we show that hydrogen peroxide (H2O2) activates the peroxidase function IDO to induce protein oxidation and inhibit dioxygenase activity. Exposure IDO-expressing cells or recombinant human (rIDO) H2O2 inhibited activity in manner abrogated by l-Trp. Dioxygenase inhibition correlated with IDO-catalyzed consumption, compound I-mediated formation...
The rupture of atherosclerotic plaque contributes significantly to cardiovascular disease. Plasma concentrations bilirubin-a byproduct heme catabolism-inversely associate with risk disease, although the link between bilirubin and atherosclerosis remains unclear.To assess role in stability, we crossed Bvra-/- Apoe-/- mice used tandem stenosis model instability. Human coronary arteries were obtained from heart transplant recipients. Analysis bile pigments, metabolism, proteomics performed by...
Gas flow pulsation was employed to improve the drying of porous pharmaceutical granules in a cylindrical fluidized bed. In our approach, fraction total oscillating intermittently and periodically, typically at 3 Hz during 2 min remaining constant other each 4 cycle. It found that such pulsation-assisted fluidization not only shortened time but also enhanced homogeneity. A transition behavior, reflected by distinct bed dominant frequencies, observed.
Cannabidiol (CBD) is currently being investigated as a novel therapeutic for the treatment of CNS disorders like schizophrenia and epilepsy. ABC transporters such P-glycoprotein (P-gp) breast cancer resistance protein (Bcrp) mediate pharmacoresistance in these disorders. P-gp Bcrp are expressed at blood brain barrier (BBB) reduce uptake substrate drugs including various antipsychotics anticonvulsants. It therefore important to assess whether CBD prone mediated by Bcrp. Moreover, it has...
Aspirin nonadherence and its associated increase in cardiovascular cerebrovascular events is well described; however, the prevalence of aspirin among high-risk pregnant women at risk preeclampsia influence on clinical outcomes remains unclear. Our study examined resistance quantitatively (platelet function analyzer 100 plasma salicylic acid) relative to adherence. High-risk were recruited across 3 centers South West Sydney Local Health District. Simultaneous clinic data, blood sample,...
Chronic inflammatory bowel disease (IBD) is a condition with multifactorial pathophysiology. To date, there no permanent cure and the primarily managed by immunosuppressive drugs; long-term use promotes serious side effects including increased risk malignancies. The current study aimed to target neutrophil-myeloperoxidase, key contributor pathogenesis of IBD, through AZD3241that inhibits extracellular myeloperoxidase. Experimental colitis was induced in C57BL/6 male mice 2% dextran sodium...
The acute phase protein serum amyloid A (SAA), a marker of inflammation, induces expression pro-inflammatory and pro-thrombotic mediators including ICAM-1, VCAM-1, IL-6, IL-8, MCP-1 tissue factor (TF) in both monocytes/macrophages endothelial cells, dysfunction-a precursor to atherosclerosis. In this study, we determined the effect pharmacological inhibition known SAA receptors on activities human carotid artery cells (HCtAEC). HCtAEC were pre-treated with inhibitors formyl peptide...
Inflammatory bowel disease (IBD) is a chronic condition characterised by leukocyte recruitment to the gut mucosa. Leukocyte myeloperoxidase (MPO) produces two-electron oxidant hypochlorous acid (HOCl), damaging tissue and playing role in cellular recruitment, thereby exacerbating injury. We tested whether MPO-inhibitor, 4-Methoxy-TEMPO (MetT), ameliorates experimental IBD. Colitis was induced C57BL/6 mice 3% w/v dextran-sodium-sulfate (DSS) drinking water ad libitum over 9-days with MetT (15...
Serum amyloid A (SAA) promotes endothelial inflammation and dysfunction that is associated with cardiovascular disease renal pathologies. SAA an apoprotein for high-density lipoprotein (HDL) its sequestration to HDL diminishes bioactivity. Herein we investigated the effect of co-supplementing on SAA-mediated changes vascular function in apolipoprotein E-deficient (ApoE-/-) mice absence a high-fat diet. Male ApoE-/- received recombinant human or vehicle (control) by intraperitoneal (i.p.)...
The role of oxidative damage in the aetiology coronary disease remains controversial, as clinical trials investigating effect antioxidants have not generally been positive. In present study, 227 cases, identified from a cohort were matched, by age and gender, with 420 controls nested case-control design. Stored plasma samples analysed for F2-isoprostanes stable isotope dilution MS, specifically oxidized forms apoA-I (apolipoprotein A-I) HPLC HDL (high-density lipoprotein). Median values...