A5036386407- Laser Applications in Dentistry and Medicine
- Photoreceptor and optogenetics research
- Iron Metabolism and Disorders
- Alzheimer's disease research and treatments
- Neurological diseases and metabolism
- Trace Elements in Health
- Transcranial Magnetic Stimulation Studies
- Hemoglobinopathies and Related Disorders
- Medical and Biological Ozone Research
- RNA regulation and disease
- Folate and B Vitamins Research
- Nicotinic Acetylcholine Receptors Study
- Parkinson's Disease Mechanisms and Treatments
- Bioinformatics and Genomic Networks
- Saffron Plant Research Studies
- Inhalation and Respiratory Drug Delivery
- Hydrogen's biological and therapeutic effects
- Pain Management and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neurological Disease Mechanisms and Treatments
- Gene expression and cancer classification
- Migraine and Headache Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Mitochondrial Function and Pathology
- Diet and metabolism studies
University of Newcastle Australia
2008-2025
The University of Sydney
2014-2024
Robert Bosch (Australia)
2012-2020
The University of Adelaide
2018
Hunter Medical Research Institute
2010-2016
Callaghan Innovation
2016
Babcock & Wilcox (Spain)
2015
UNSW Sydney
2015
Australian Research Council
2013
Ottawa Hospital
2011
Previous work has demonstrated the efficacy of irradiating tissue with red to infrared light in mitigating cerebral pathology and degeneration animal models stroke, traumatic brain injury, parkinsonism Alzheimer's disease (AD). Using mouse models, we explored neuroprotective effect near (NIr) treatment, delivered at an age when substantial is already present cortex.We studied two AD-related pathologies: K369I tau transgenic model (K3), engineered develop neurofibrillary tangles,...
Objective To examine whether near‐infrared light (NIr) treatment reduces clinical signs and/or offers neuroprotection in a subacute 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) monkey model of Parkinson disease. Methods We implanted an optical fiber device that delivered NIr (670nm) to the midbrain macaque monkeys, close substantia nigra both sides. MPTP injections (1.5–2.1mg/kg) were made over 5‐ 7‐day period, during which time was turned on. This then followed by 3‐week survival...
Increased iron levels and dysregulated homeostasis, or both, occur in several lung diseases. Here, the effects of accumulation on pathogenesis pulmonary fibrosis associated function decline was investigated using a combination murine models overload bleomycin-induced fibrosis, primary human fibroblasts treated with iron, histological samples from patients without idiopathic (IPF). Iron are significantly increased overloaded transferrin receptor 2 (Tfr2) mutant mice homeostatic regulator...
Abstract Alzheimer’s disease (AD) is an age-related disease, with loss of integrity the blood–brain barrier (BBB) being early feature. Cellular senescence one reported nine hallmarks aging. Here, we show for first time presence senescent cells in vasculature AD patients and mouse models AD. Senescent endothelial pericytes are present APP/PS1 transgenic mice but not wild-type littermates at amyloid deposition. In vitro, display altered VE-cadherin expression cell junction formation increased...
Previous experimental studies have documented the neuroprotection of damaged or diseased cells after applying, from outside brain, near-infrared light (NIr) to brain by using external light-emitting diodes (LEDs) laser devices. In present study, authors describe an effective and reliable surgical method applying inside NIr brain. They developed a novel internal device that delivers regions very close target cells. suggest this will be useful in within large human particularly if deep...
Background Recent Alzheimer's disease (AD) research has focused on finding biomarkers to identify at the pre-clinical stage of mild cognitive impairment (MCI), allowing treatment be initiated before irreversible damage occurs. Many studies have examined brain imaging or cerebrospinal fluid but there is also growing interest in blood biomarkers. The Disease Neuroimaging Initiative (ADNI) generated data 190 plasma analytes 566 individuals with MCI, AD normal cognition. We conducted independent...
Accumulating evidence highlights links between iron regulation and respiratory disease. Here, we assessed the relationship levels regulatory responses in clinical experimental asthma. We show that cell-free are reduced bronchoalveolar lavage (BAL) supernatant of severe or mild–moderate asthma patients correlate with lower forced expiratory volume 1 s (FEV ). Conversely, iron-loaded cell numbers were increased BAL these FEV /forced vital capacity (FVC) ratio. The airway tissue expression...
Iron and cholesterol are both essential metabolites in mammalian systems, too much or little of either can have serious clinical consequences. In addition, been associated with steatosis its progression, contributing, inter alia, to an increase hepatic oxidative stress. The interaction between iron is unclear, no consistent evidence emerging respect changes plasma on the basis status. We sought clarify role lipid metabolism by studying effects status synthesis mice differing Transcripts...
Background: There is growing evidence that the spice saffron, which contains powerful anti-oxidants, offers protection against neurodegenerative disorders, including age-related macular degeneration and Alzheimer's disease. Objective: We examined whe
Abstract Background We have shown previously that near-infrared light (NIr) treatment or photobiomodulation neuroprotects dopaminergic cells in substantia nigra pars compacta (SNc) from degeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Balb/c albino mice, a well-known model for Parkinson’s disease. The present study explores whether NIr offers neuroprotection to these C57BL/6 pigmented mice. In addition, we examine influences behavioural activity both strains after...
The 'neurodegeneration with brain iron accumulation' (NBIA) disease family entails movement or cognitive impairment, often psychiatric features. To understand how loading affects the brain, we studied mice disruption of two regulatory genes, hemochromatosis (Hfe) and transferrin receptor 2 (Tfr2). Inductively coupled plasma atomic emission spectroscopy demonstrated increased in Hfe−/− × Tfr2mut (P=0.002, n ≥5/group), primarily localized by Perls' staining to myelinated structures. Western...
Photobiomodulation (PBM)-the irradiation of tissue with low-intensity light-mitigates neuropathology in rodent models Parkinson's disease (PD) when targeted at the head ('transcranial PBM'). In humans, however, attenuation light energy by scalp and skull necessitates a different approach. We have reported that targeting PBM body also protects brain mechanism spreads from irradiated ('remote PBM'), although optimal peripheral target for remote is currently unclear. This study compared...
OBJECT The authors of this study used a newly developed intracranial optical fiber device to deliver near-infrared light (NIr) the midbrain 6-hydroxydopamine (6-OHDA)-lesioned rats, model Parkinson's disease. explored whether NIr had any impact on apomorphine-induced turning behavior and it was neuroprotective. METHODS Two powers (333 nW 0.16 mW), modes delivery (pulse continuous), total doses (634 mJ 304 J) were tested, together with feasibility implant site, one considered for later use in...