A5068692796- Iron Metabolism and Disorders
- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- Cystic Fibrosis Research Advances
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Influenza Virus Research Studies
- IL-33, ST2, and ILC Pathways
- Long-Term Effects of COVID-19
- Child Nutrition and Water Access
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
Hunter Medical Research Institute
2020-2024
University of Newcastle Australia
2021-2024
Increased iron levels and dysregulated homeostasis, or both, occur in several lung diseases. Here, the effects of accumulation on pathogenesis pulmonary fibrosis associated function decline was investigated using a combination murine models overload bleomycin-induced fibrosis, primary human fibroblasts treated with iron, histological samples from patients without idiopathic (IPF). Iron are significantly increased overloaded transferrin receptor 2 (Tfr2) mutant mice homeostatic regulator...
Accumulating evidence highlights links between iron regulation and respiratory disease. Here, we assessed the relationship levels regulatory responses in clinical experimental asthma. We show that cell-free are reduced bronchoalveolar lavage (BAL) supernatant of severe or mild–moderate asthma patients correlate with lower forced expiratory volume 1 s (FEV ). Conversely, iron-loaded cell numbers were increased BAL these FEV /forced vital capacity (FVC) ratio. The airway tissue expression...
Rationale and Objectives: Iron availability metabolism are important in the pathogenesis of bacterial infections. More recently, links have been reported between iron severity viral In this study, we characterize a crucial relationship IAV infection disease. Methods: Iron-related gene expression was assessed human airway epithelial cells (AEC) infected with IAV. AECs were cultured ferric iron, iron-loaded transferrin, or chelator, deferoxamine (DFO), prior to Mice placed on high diet for 8...
Abstract Background and Objective Severe asthma is a heterogeneous disease with subtype classification according to dominant airway infiltrates, including eosinophilic (Type 2 high), or non‐eosinophilic asthma. Non‐eosinophilic further divided into paucigranulocytic neutrophilic characterized by elevated neutrophils, mixed Type 1 17 cytokines in the airways. has few effective treatments many patients do not qualify for biologic therapies. The cystic fibrosis transmembrane conductance...
Maternal iron deficiency occurs in 40–50% of all pregnancies and is associated with an increased risk respiratory disease asthma children. We used murine models to examine the effects lower status during pregnancy on lung function, inflammation structure, as well its contribution severity offspring. A low diet impairs increases airway inflammation, alters structure absence presence experimental asthma. further these major features offspring Importantly, a neutrophilic which indicative more...
There is increasing evidence that third hand exposure to e-cigarette vapor (e-vapor) can have detrimental effects on the lungs. However, whether maternal during pregnancy results in harmful changes offspring unknown. Using two different settings (low versus high power), BALB/c mice were subjected e-vapor (e-vapor deposited onto towels, towels changed daily) absence or presence of nicotine, before, during, and after pregnancy. Male adult then infected with mouse-adapted influenza A virus...
<b>Introduction:</b> The interplay between iron availability, immune responses and microbes is important in the pathogenesis of bacterial infections. However, relationship respiratory viral infections metabolism largely unknown. Here we investigated levels, influenza A virus (IAV) <b>Methods:</b> Human bronchial epithelial cells (BECs) were cultured with ferric ammonium citrate (FAC) prior to infection IAV (H1N1) assess effects increased on human airway cells. BALB/c mice intranasally...