A5001367395- Pulmonary Hypertension Research and Treatments
- Asthma and respiratory diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Iron Metabolism and Disorders
- Neonatal Respiratory Health Research
- Inhalation and Respiratory Drug Delivery
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiac Fibrosis and Remodeling
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Circular RNAs in diseases
- RNA modifications and cancer
- IL-33, ST2, and ILC Pathways
- HIV Research and Treatment
- Gut microbiota and health
- Pediatric health and respiratory diseases
- Medicinal Plants and Neuroprotection
- Protein Tyrosine Phosphatases
- Antimicrobial Peptides and Activities
- Bacterial biofilms and quorum sensing
- Vascular Anomalies and Treatments
- Probiotics and Fermented Foods
- Inflammasome and immune disorders
- Renin-Angiotensin System Studies
- Galectins and Cancer Biology
Islamic University
2025
California State University, East Bay
2023-2024
Stanford Medicine
2021-2024
Stanford University
2020-2023
California State University System
2023
Hunter Medical Research Institute
2017-2022
Pulmonary and Allergy Associates
2022
University of Newcastle Australia
2017-2021
Pulmonary and Critical Care Associates
2021
Government College University, Faisalabad
2018
Severe, steroid-resistant asthma is the major unmet need in therapy. Disease heterogeneity and poor understanding of pathogenic mechanisms hampers identification therapeutic targets. Excessive nucleotide-binding oligomerization domain-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome concomitant IL-1β responses occur chronic obstructive pulmonary disease, respiratory infections, neutrophilic asthma. However, direct contributions to pathogenesis, involved, potential for...
Increased iron levels and dysregulated homeostasis, or both, occur in several lung diseases. Here, the effects of accumulation on pathogenesis pulmonary fibrosis associated function decline was investigated using a combination murine models overload bleomycin-induced fibrosis, primary human fibroblasts treated with iron, histological samples from patients without idiopathic (IPF). Iron are significantly increased overloaded transferrin receptor 2 (Tfr2) mutant mice homeostatic regulator...
To investigate potential antioxidant, antimicrobial, cytotoxic and analgesic activities of ethanolic extract Mentha arvensis L. in different vivo vitro experimental models. In DPPH radical scavenging assay was used to evaluate the antioxidant activity plant extract. carried out by acetic acid-induced writhing test Swiss albino mice. All studies mice were undertaken at doses 250 500 mg/kg body weight. Antibacterial studied disk diffusion against some Gram-positive Gram-negative bacterial...
Accumulating evidence highlights links between iron regulation and respiratory disease. Here, we assessed the relationship levels regulatory responses in clinical experimental asthma. We show that cell-free are reduced bronchoalveolar lavage (BAL) supernatant of severe or mild–moderate asthma patients correlate with lower forced expiratory volume 1 s (FEV ). Conversely, iron-loaded cell numbers were increased BAL these FEV /forced vital capacity (FVC) ratio. The airway tissue expression...
To clarify the role of progressive heavy training on vascular volumes and hematologic status, seven untrained males [maximal O2 uptake (VO2max) = 45.1 +/- 1.1 (SE) ml.kg-1.min-1] cycled 2 h/day at an estimated 62% VO2max. Training was conducted five to six times per week for approximately 8 wk. During this time, VO2max increased (P less than 0.05) by 17.2%. Plasma volume (PV) measured 125I from 3,068 104 ml 0 wk 3,490 126 4 then plateaued during remaining four (3,362 113 ml). Red cell (RBC)...
We continue to struggle with the prevention and treatment of influenza virus. The 2009 swine flu pandemic, caused by H1N1 strain A, resulted in numerous fatalities. threat remains a significant concern for global health, development novel drugs targeting these viruses is highly desirable. objective this study explore inhibitory potential terpenoid compounds against Nucleoprotein (NP) A virus, which effective drug target due its ability facilitate transcription replication viral RNA. In...
Right ventricular (RV) function is the predominant determinant of survival in patients with pulmonary arterial hypertension (PAH). In preclinical models, pharmacological activation BMP (bone morphogenetic protein) signaling FK506 (tacrolimus) improved RV by decreasing afterload. therapy further stabilized three end-stage PAH. Whether has direct effects on pressure-overloaded right ventricle yet unknown. We hypothesized that increasing cardiac improves structure and a model fixed afterload...
To explore the efficacy of ethanolic leaf extract Typhonium trilobatum L. Schott in treating diarrhea, pain and inflammation using experimental models. In present study, acetic acid-induced writhing, xylene-induced ear edema castor oil-induced diarrheal model were used to evaluate analgesic, anti-inflammatory anti-diarrheal activities, respectively. Acute toxicity test was carried out fix safe doses plant extract. The demonstrated a significant inhibition writhing (P < 0.01) compared with...
No prior proteomic screening study has centred on the right ventricle (RV) in pulmonary arterial hypertension (PAH). This investigates circulating profile associated with heart maladaptive phenotype (RHMP) PAH. Plasma profiling was performed using multiplex immunoassay 121 (discovery cohort) and 76 (validation PAH patients. The association between markers RHMP, defined by Mayo score (combining RV strain, New York Heart Association (NYHA) class N-terminal pro-brain natriuretic peptide...
Molecular mechanisms by which sex steroids interact with P. aeruginosa to modulate its virulence have yet be reported. Our work provides the first characterization of a steroid-induced membrane stress mechanism promoting virulence, includes release proinflammatory outer vesicles, resulting in inflammation, host tissue damage, and reduced bacterial clearance. We further demonstrate that at nanomolar (physiological) concentrations, male female promote clinical strains based on their dynamic...