A5076879736- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Congenital Heart Disease Studies
- Cardiac Valve Diseases and Treatments
- Cardiovascular Issues in Pregnancy
- Cardiovascular Disease and Adiposity
- Superconducting Materials and Applications
- Cardiomyopathy and Myosin Studies
University of Colorado Denver
2014-2021
University of Colorado Anschutz Medical Campus
2020-2021
Children's Hospital Colorado
2018-2021
The temporal sequence of events underlying functional right ventricular (RV) recovery after improvement pulmonary hypertension-associated pressure overload is unknown. We sought to establish a novel mouse model gradual RV from and use it delineate reverse-remodelling events.
Right ventricular (RV) function is the predominant determinant of survival in patients with pulmonary arterial hypertension (PAH). In preclinical models, pharmacological activation BMP (bone morphogenetic protein) signaling FK506 (tacrolimus) improved RV by decreasing afterload. therapy further stabilized three end-stage PAH. Whether has direct effects on pressure-overloaded right ventricle yet unknown. We hypothesized that increasing cardiac improves structure and a model fixed afterload...
The right ventricle and left are physically coupled through the interventricular septum. Therefore, changes in geometry mechanics of one can directly affect function other. In treatment pediatric pulmonary arterial hypertension, is often overlooked, with clinical focus primarily on improving ventricular function. Pediatric hypertension represents a disease distinct from adult based etiology survival rates. We aimed to assess torsion rate its role dysfunction. Cardiac magnetic resonance...
Pulmonary hypertension (PH) results in right ventricular (RV) pressure overload and eventual failure. Current research efforts have focused on the RV while overlooking left ventricle (LV), which is responsible for mechanically assisting during contraction. The objective of this study to evaluate biomechanical gene expression changes occurring LV due a mouse model. Nine male mice were divided into two groups: (a) pulmonary arterial banding (PAB, N = 4) (b) sham surgery (Sham, 5). Tagged...
Aims Ventricular–vascular coupling, the ratio between right ventricle’s contractile state (E es ) and its afterload a ), may be useful metric in management of paediatric pulmonary arterial hypertension (PAH). In this study we assess prognostic capacity ventricular–vascular coupling /E derived using ventricular (RV) pressure alone children with PAH. Methods One hundred thirty patients who were diagnosed PAH via heart catheterisation retrospectively reviewed over 10-year period. Maximum RV...
The role of interventricular mechanics in pediatric pulmonary arterial hypertension (PAH) and its relation to right ventricular (RV) dysfunction has been largely overlooked. Here, we characterize the impact maintained pressure overload RV–pulmonary artery (PA) axis on myocardial strain left (LV) PAH patients comparison a preclinical PA-banding (PAB) mouse model. We hypothesize that PAB model mimics important aspects may be beneficial as surrogate for some longitudinal interventional studies...
Introduction: Right ventricular (RV) function determines the prognosis of pulmonary hypertension. Capillary rarefaction using 2D imaging has been proposed as hallmark RV failure, although this paradigm is controversially discussed. By applying 3D deep-tissue imaging, we characterized adaptive and maladaptive response capillaries in pressure-overloaded hypertrophy failure. Methods Results: Mice subjected to artery banding (PAB) were harvested after 3 weeks (w) (compensated hypertrophy) 7w...
Introduction: The left ventricle (LV) is known to transfer kinetic mechanical energy the right (RV) during systole. Normally, RV relies on this assistance for up 70% of its pressure generation. However, biventricular relationship and effect function has not been explored in progression overloaded RV. In study, we developed a longitudinal mouse model pulmonary arterial (PA)-banding concomitant with transverse aortic constriction (TAC) initiate an adaptive LV remodeling response. We...