A5055650329- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Congenital Heart Disease Studies
- Cardiovascular Health and Disease Prevention
- Cardiac Valve Diseases and Treatments
- Cardiovascular Disease and Adiposity
- Elasticity and Material Modeling
- Birth, Development, and Health
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Connective tissue disorders research
- Cardiovascular Issues in Pregnancy
- Pregnancy and preeclampsia studies
- Hemodynamic Monitoring and Therapy
- Aortic Disease and Treatment Approaches
- Cardiovascular Effects of Exercise
- Ultrasound and Cavitation Phenomena
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Adipose Tissue and Metabolism
- Aortic aneurysm repair treatments
- Cardiac Arrhythmias and Treatments
- Cardiovascular and exercise physiology
University of Colorado Denver
2015-2024
Children's Hospital Colorado
2012-2024
University of Colorado Anschutz Medical Campus
2015-2024
Texas A&M University
2017-2024
Bioengineering Center
2010-2023
The Medical Center of Aurora
2021-2023
Denver Health Medical Center
2021
National Jewish Health
2015-2017
Smith College
2017
Syracuse University
2017
A model for a moderately deep underwater explosion bubble is developed that integrates the shock wave and oscillation phases of motion. hyperacoustic relationship formulated relates volume acceleration to far-field pressure profile during shock-wave phase, thereby providing initial conditions subsequent phase. For latter, equations bubble-surface response are derived include effects in both external liquid internal gas. The then specialized case spherical bubble, displacement histories...
Extracellular matrix remodeling has been proposed as one mechanism by which proximal pulmonary arteries stiffen during arterial hypertension (PAH). Although some attention paid to the role of collagen and metallomatrix proteins in affecting vascular stiffness, much less work performed on changes elastin structure-function relationships PAH. Such is warranted, given importance structural protein primarily responsible for passive elastic behavior these conduit arteries. Here, we study fresh...
Objective: Vascular pathology, characterized by impaired vasoreactivity and mitochondrial respiration, differs between the sexes. Housing rats under thermoneutral (TN) conditions causes vascular dysfunction perturbed metabolism. We hypothesized that thoracic perivascular adipose tissue (tPVAT), a vasoregulatory depot known to have brown (BAT) phenotype, remodels mainly white (WAT) phenotype in housed at TN, driving diminished sex-dependent manner. Methods: Male female Wistar were either room...
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Recent studies have indicated that systemic arterial stiffening is a precursor to hypertension and hypertension, in turn, can perpetuate stiffening. Pulmonary artery (PA) also well documented occur pulmonary (PH), there evidence vascular stiffness (PVS) may be better predictor of outcome than resistance (PVR). We hypothesized the decreased flow‐damping function elastic PAs PH likely initiates and/or perpetuates dysfunction microvasculature. shown large‐vessel increases flow pulsatility...
Background— The effects of nonpulsatile flow on the aorta are unknown. Our aim was to examine structure from patients with continuous-flow left ventricular assist devices (LVADs) and directly measure aortic wall composition stiffness. Methods Results— Age-matched samples were collected consecutive heart failure (HF) at time transplantation compared nonfailing donor hearts. An unbiased stereological approach used quantify morphometry composition, biomechanical testing performed determine...
Pulmonary arterial hypertension (PAH) is a devastating disease with significant morbidity and mortality. At the macroscopic level, progression observed as complex interplay between mean pulmonary artery pressure, vascular resistance, stiffness, size, flow. Wall shear stress (WSS) known to mediate or be dependent on number of these factors. Given that WSS promote architectural vessel remodeling, it imperative changes this factor quantified in presence PAH.
Background Qualitative and quantitative flow hemodynamic indexes have been shown to reflect right ventricular ( RV ) afterload function in pulmonary hypertension PH ). We aimed quantify formations arteries using 4‐dimensional cardiac magnetic resonance imaging the spatial velocity derivatives helicity vorticity a heterogeneous population. Methods Results Patients with (n=35) controls (n=10) underwent study for computation of main artery MPA ), artery, outflow tract. Helicity were correlated...
Pulmonary hypertension (PH) is associated with proximal pulmonary arterial remodeling characterized by increased vessel diameter, wall thickening, and stiffness. In vivo assessment of shear stress (WSS) may provide insights into the relationships between hemodynamics vascular remodeling. We investigated relationship main artery (MPA) WSS as well markers As part a prospective study, 17 PH patients 5 controls underwent same-day four-dimensional flow cardiac magnetic resonance imaging (4-D CMR)...
Many common diseases involve impaired tissue perfusion, and heterogeneous distribution of blood flow in the microvasculature contributes to this pathology. The physiological mechanisms regulating homogeneity/heterogeneity microvascular perfusion are presently unknown. Using established empirical formulations for viscosity modeling vivo (blood vessels) vitro (glass tubes), we showed that formulation predicts more homogenous networks at arteriolar capillary levels. Next, homogeneous under...
To investigate the possibility that vorticity assessed by four-dimensional flow cardiac magnetic resonance (4D-Flow CMR) in left ventricle of patients with mild-to-moderate chronic obstructive pulmonary disease (COPD) is a potential marker early LV diastolic dysfunction (LVDD) and more sensitive than standard echocardiography, whether changes are associated quantitative computed tomography (CT) clinical markers COPD, right ventricular (RV) echocardiographic indicative interdependency.Sixteen...
Key points Despite growing interest in right ventricular form and function diseased states, there is a paucity of data regarding characteristics – namely contractile lusitropic reserve, as well ventricular‐arterial coupling, the healthy heart during rest, submaximal peak exercise. Pressure‐volume analysis ventricle, invasive cardiopulmonary exercise testing, demonstrates that has enormous with three‐ or fourfold increase all metrics contractility, myocardial energy production utilization....
Abstract Acute hypoxia increases pulmonary arterial (PA) pressures, though its effect on right ventricular (RV) function is controversial. The objective of this study was to characterize exertional RV performance during acute hypoxia. Ten healthy participants (34 ± 10 years, 7 males) completed three visits: visits 1 and 2 included non‐invasive normoxic (fraction inspired oxygen () = 0.21) isobaric hypoxic ( 0.12) cardiopulmonary exercise testing (CPET) determine normoxic/hypoxic maximal...
Micro-invasive glaucoma surgery with the Glaukos iStent® or iStent inject® (Glaukos Corporation, Laguna Hills, CA, USA) is intended to create a bypass through trabecular meshwork Schlemm's canal improve aqueous outflow natural physiologic pathway. While devices have been evaluated in ex vivo anterior segment models, they not previously whole eye perfusion models nor characterized by computational fluid dynamics. Intraocular pressure (IOP) reduction was an human model. Numerical modeling,...
Stiffening of large arteries is increasingly used as an independent predictor risk and therapeutic outcome for small artery dysfunction in many diseases including pulmonary hypertension. The molecular mechanisms mediating downstream vascular cell responses to stiffening remain unclear. We hypothesize that high pulsatility flow, induced by stiffening, causes inflammatory endothelial cells (PAECs) through toll-like receptor (TLR) pathways. To recapitulate the effect occurs hypertension,...
Main pulmonary artery (MPA) stiffness and abnormal flow haemodynamics in arterial hypertension (PAH) are strongly associated with elevated right ventricular (RV) afterload disease severity poor clinical outcomes adults PAH. However, the long-term effects of MPA on RV function children PAH remain poorly understood. This study is first comprehensive evaluation PAH, delineating mechanistic relationship between as well prognostic ability these measures regarding outcomes.Fifty-six diagnosed...
Developing clinical work suggests that vascular stiffening plays a role in the progression of pulmonary hypertension (PH), while recent studies animal models hypoxic PH have found significant proximal diseased population. Here, we develop and validate minimally invasive, clinically realizable method to estimate local elastic modulus arteries from pressure-diameter (PD) data. PD measurements were made main 16 calves; lumen diameter was assessed using color M-mode tissue Doppler imaging...