A5100377253- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Inflammasome and immune disorders
- Cancer, Hypoxia, and Metabolism
- Dialysis and Renal Disease Management
- Cell death mechanisms and regulation
- Gout, Hyperuricemia, Uric Acid
- Acute Kidney Injury Research
- Platelet Disorders and Treatments
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Muscle and Compartmental Disorders
- Streptococcal Infections and Treatments
- Genetic Syndromes and Imprinting
- Renal and Vascular Pathologies
- Mitochondrial Function and Pathology
- Ubiquitin and proteasome pathways
- Eicosanoids and Hypertension Pharmacology
- Systemic Lupus Erythematosus Research
- Parathyroid Disorders and Treatments
- Peroxisome Proliferator-Activated Receptors
- Renal cell carcinoma treatment
- Beetle Biology and Toxicology Studies
- Tryptophan and brain disorders
Northwest University
2023-2025
Ministry of Education of the People's Republic of China
2023-2025
University of Technology Sydney
2023-2024
Shuguang Hospital
2018-2024
Shanghai University of Traditional Chinese Medicine
2015-2024
First Hospital of China Medical University
2018-2024
China Medical University
2018-2024
Woolcock Institute of Medical Research
2023
Macquarie University
2023
Mudanjiang Medical University
2022
Chronic kidney disease (CKD) is a public health problem largely caused by diabetes. The epidemiology of diabetes mellitus-related CKD (CKD-DM) could provide specific support to lessen global, regional, and national burden.Data were derived from the GBD 2019 study, including four measures age-standardized rates (ASRs). Estimated annual percentage changes 95% CIs calculated evaluate variation trend ASRs.Diabetes majority new cases patients with in all regions. All ASRs for type 2...
Telitacicept, a B lymphocyte stimulator/A proliferation-inducing ligand dual-target fusion protein, has recently been used in autoimmune diseases. We assessed the efficacy and safety of telitacicept immunoglobulin A nephropathy (IgAN) patients.
Oxidative stress contributes substantially to podocyte injury, which plays an important role in the development of diabetic kidney disease. The mechanism hyperglycemia-induced oxidative podocytes is not fully understood. Glucose-6-phosphate dehydrogenase (G6PD) critical maintaining NADPH, cofactor for antioxidant system. Here, we hypothesized that high glucose induced ubiquitination and degradation G6PD, injured by reactive oxygen species (ROS) accumulation. We found G6PD protein expression...
Enzymatically upgrading furfural (FAL), the crude platform chemical derived from biomass, to value-added furfuryl alcohol (FOL) has attracted considerable interest because of its high conversion and selectivity. However, conventional biotransformation FAL FOL was limited by difficulties in coenzyme regeneration. Herein, visible light-driven selective hydrogenation realized on basis a coupled process that consisted photocatalyst dehydrogenase (ADH). The QDs/g-C3N4 nanosheet prepared "one-pot"...
Excessive activation of NLRP3 inflammasome and down-regulation Sirt1/Smad3 deacetylation pathway play a significant role in the evolution renal fibrosis. In China, it has been well known that Chinese herbal medicine is markedly effective treating chronic kidney disease (CKD). Shen Shuai IIRecipe (SSR) used clinically for more than 20 years confirmed to be improvements function However, specific mechanisms under efficacy require further research. The purpose this study was evaluate whether...
Isopropyl 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate (IDHP) is one of the main bioactive metabolites Chinese medicinal herb Danshen, which can be absorbed into blood compounds by oral administration Compound Danshen dripping pills (CDDPs). Previous study showed that IDHP exerted anti-inflammatory effects abolishing secretion proinflammatory factors stimulated lipopolysaccharide (LPS). However, on LPS-induced acute lung injury (ALI) are not fully understood. In present study, we observed...
Rationale: Capillaries are composed of endothelial cells and the surrounding mural cells, pericytes. Microvascular repair after injury involves not only proliferation but also pericyte-based vessel stabilization. Exogenous bone marrow derived-putative progenitor (b-pEPCs) have potential for vascular repair; however, their effect on structure stabilization pericyte-related pathobiological outcomes in injured kidney has been fully examined. Methods: We applied ischemia-reperfusion (IR) to...
Gasdermin (GSDM) family proteins were recently identified as the executioner of pyroptosis. The mechanism pyroptosis mediated by gasdermin D (GSDMD) (a member GSDM family) in humans and mice is well understood. In pyroptosis, mouse human GSDMDs are cleaved activated proinflammatory caspases (caspase-1, 4, 5, or 11) to produce anamino-terminal domain (GSDMD-NT) a carboxyl-terminal (GSDMD-CT). GSDMD-NT drives cell membrane rupture, which leads pyroptotic death cells. expression porcine GSDMD...
High-fat diet (HFD) consumption and tobacco smoking are risk factors for chronic kidney disease. E-cigarettes have gained significant popularity among younger populations worldwide, especially overweight individuals. It is unclear whether vaping interacts with HFD to impact renal health. In this study, Balb/c mice (male, 7 weeks old) were fed a pellet (43% fat, 20 kJ/g) 16 when exposed nicotine or nicotine-free e-vapour from 11 16. While alone increased collagen Ia IV depositions, it did not...
<b><i>Background/Aims:</i></b> IgA nephropathy (IgAN) is a common form of primary glomerulonephritis worldwide. Previous studies indicated that <i>IL-10</i> single nucleotide polymorphisms (SNP) play an important role in IgAN pathogenesis, but the results were controversy. This study aimed to investigate association between SNPs (rs1800872, rs1800871, and rs1800896) with Chinese Han population. <b><i>Methods:</i></b> We conducted...
IFN-γ was reported to be involved in the development and progression of Immunoglobulin A nephropathy (IgAN), however, few studies have investigated association between polymorphisms IgAN. Therefore, we performed a case-control study assess risk IgAN.Sequenom MassARRAY used genotype two SNPs (rs1861494 rs2430561) 351 patients with IgAN 310 healthy controls. Associations were evaluated as odd ratios (OR) 95% confidence intervals (CI).No found rs1861494 or clinical parameters. For rs2430561, AA...
This study was designed to determine the levels of survivin expression and identify its clinical significance as a prognostic factor for stage III non-small cell lung cancer (NSCLC). A total 210 cases NSCLC were collected vascular endothelial growth (VEGF-A) in tumor tissues investigated using immunohistochemistry (IHC). The medical records patients reviewed association with course. Of tissues, 112 (53.3%) demonstrated positive protein. Coexpression VEGF-A identified. 5-year survival rate...
Background . Chronic kidney disease (CKD) is a global health burden with high mortality and morbidity. Clinical efficacy has been demonstrated for Shen Shuai II Recipe (SSR), an approved widely used Chinese herbal medicine over 20 years in China, to attenuate CKD progression. In this study, we explored the underlying molecular mechanisms of SSR benefits studied its effects on apoptosis, critical process development was induced rats 5/6 renal ablation infarction (A/I). Eight weeks after...