A5023129008- Protein Hydrolysis and Bioactive Peptides
- Echinoderm biology and ecology
- Gout, Hyperuricemia, Uric Acid
- Chronic Kidney Disease and Diabetes
- Mitochondrial Function and Pathology
- Blood Pressure and Hypertension Studies
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Function and Risk Factors
- Medicinal Plant Pharmacodynamics Research
- Microbial Metabolism and Applications
- Peroxisome Proliferator-Activated Receptors
- Medical Research and Treatments
- Diabetes Management and Research
- Cardiovascular Health and Disease Prevention
- Metabolism and Genetic Disorders
- Immune Cell Function and Interaction
- Birth, Development, and Health
- Chronic Disease Management Strategies
- Gut microbiota and health
- Cardiac Imaging and Diagnostics
- Obesity and Health Practices
- Renal Diseases and Glomerulopathies
- Renal cell carcinoma treatment
- Tissue Engineering and Regenerative Medicine
- Liver Disease Diagnosis and Treatment
Southern Medical University
2023-2025
Guangdong Provincial People's Hospital
2023-2025
Guangdong Academy of Medical Sciences
2023-2025
Ocean University of China
2021-2024
Shanghai University of Traditional Chinese Medicine
2021-2024
Shuguang Hospital
2021-2024
First Affiliated Hospital of Zhengzhou University
2017-2022
Peking Union Medical College Hospital
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
China-Japan Friendship Hospital
2020-2021
Abstract Background Cardiometabolic multimorbidity (CMM) and obesity represent two major health problems. The relationship between adiposity indices CMM, however, remains understudied. This study aimed to investigate the associations of body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR), a shape (ABSI), roundness (BRI), conicity (CI) with CMM among Chinese adults. Methods Data 101,973 participants were collected from population-based screening project in Southern...
Icariin (ICA) is a bioactive flavonoid extracted from Epimedium brevicornum Maxim and exhibits variety of pharmacological activities including antiinflammatory antioxidant effects. Recently, icariin has shown renoprotective role by inhibiting pathological matrix. However, the underlying mechanisms efficacy remain unknown. This study aimed to determine effects on renal fibrosis explore its molecular mechanisms. Chronic kidney disease (CKD) was induced in rats with 5/6 ablation infarction...
The sea cucumber intestine is a major by-product of processing and contains high levels protein. In this study, we isolated identified 28 novel osteogenic peptides from intestinal hydrolysis by the activity-tracking method for first time. vitro experimental results showed that compared with molecular weight, (SCIP) weight <3 kDa more significantly promoted proliferation mineralized nodules MC3T3-E1 cell exhibited potential integrin binding capacity. vivo SCIP supplement increased...
Abstract Sea cucumber intestines are considered a valuable resource in the sea processing industry due to their balanced amino acid composition. Studies have reported that peptides rich glutamate and branched‐chain acids anti‐fatigue properties. However, function of intestine reducing exercise‐induced fatigue remains unclear. In this study, we enzymatically hydrolyzed low molecular weight from (SCIP) administered SCIP orally mice examine its effects on using swimming pole‐climbing exhaustion...
Novel peptides from sea cucumber intestinal supplement upregulated glutamine metabolism to promote chondrocyte proliferation, and finally promoting longitudinal bone growth.
ABSTRACT Sex differences significantly influence the prognosis of left ventricular hypertrophy (LVH). To investigate sex‐specific in incidence major adverse cardiovascular event (MACE) among individuals with LVH, we enrolled 14 636 (mean age 57 years, women 59.1%) participants high risk for diseases (CVD) from sub‐cohort China PEACE Million Persons Project. LVH was identified by echocardiography dividing mass (LVM) body surface area (BSA), height 1.7 , or 2.7 using validated cutoff values....
Influenza A virus still represents a noticeable epidemic risk to international public health at present, despite the extensive use of vaccines and anti-viral drugs. In fight against pathogens, immune defence lines consisting diverse lymphocytes are indispensable for humans. However, role infection subsequent abnormal cell death remains be explored. Different T subpopulations have distinct characterizations functions, we reveal high heterogeneity susceptibility viral biological responses such...
Liver fibrosis plays a critical role in liver disease progression. A sialoglycopeptide from the Gadus morhua eggs (Gm-SGPP) was identified having 7000 Da molecular weight with core pentasaccharide structure and osteogenesis activity. However, whether Gm-SGPP is beneficial to remains unknown. In this study, mice were intraperitoneally injected 2.5% CCl4 (10 mL/kg) orally administered (500 mg/kg) for 30 days. Results showed that alleviated oxidative damage lipid metabolism disorder reduced...
Colistin-resistant (Col-R) bacteria are steadily increasing, and extremely difficult to treat. New drugs or therapies urgently needed treat infections caused by these pathogens. Combination therapy with colistin other old drugs, is an important way restore the activity of colistin. This study aimed investigate in combination anti-rheumatic drug auranofin against Col-R Gram-negative bacteria. The results checkerboard analysis demonstrated that synergized Time-kill assays showed significant...
Objective: To determine the associations between triglyceride‐glucose (TyG) index and mortality from all causes cardiovascular in diabetic population. Methods: 3349 participants with diabetes mellitus (DM) 1999–2014 National Health Nutrition Examination Surveys (NHANES), aged 18–85 years were included grouped based on TyG quintiles. Mortality was followed up through December 31 th , 2015. Cox proportional hazards models used to assess hazard ratios (HRs) 95% confidence intervals (CIs). We...
Abstract Renal interstitial fibrosis (RIF) is the main pathological basis for progression of chronic kidney disease (CKD), however, effective interventions are limited. Here, we investigated effect Icariside II (ICA‐II) on RIF and explored underlying mechanisms. Rats receiving 5/6 ablation infarction (A/I) surgery were gavaged with ICA‐II (5 or 10 mg/kg) 8 weeks. In vitro, TGF‐β1‐stimulated NRK‐52E cells treated (or) oleic acid, etomoxir, ranolazine, fenofibrate, GW6471. The effects RIF,...
Abstract Background The benefits and safety of intensive blood pressure treatment in elderly hypertensive patients have been proved the STEP trial. However, relevant mechanisms for are lacking. Hypothesis We aimed to explore whether is associated with left ventricular systolic function changes as evaluated by myocardial work (MW) parameters compared standard. Methods Patients were randomized group ( n = 66, median age 66 years, 42.4% male) a (SBP) goal 110 <130 mmHg or standard 50, 63.5...
To study which subgroup of bone marrow derived cells formed myofibroblasts and the mechanism that transforming growth factor β(1)(TGFβ(1)) regulates formation macrophages into during renal fibrosis. Chimeric mice were generated by lethally irradiation C57 followed transfusion green fluorescent protein (GFP) labeled cells. Complete reconstitution was developed until 12 weeks after transplantation. The randomly divided Sham operation group, unilateral ureteral obstruction (UUO) 3 days UUO5...
This study aims to explore the effect of icariin(ICA) on mitochondrial dynamics in a rat model chronic renal failure(CRF) and investigate molecular mechanism ICA against interstitial fibrosis(RIF). CRF was induced male Sprague-Dawley(SD) rats with 5/6(ablation infarction, A/I) surgery(right kidney ablation 2/3 infarction left kidney). Four weeks after surgery, were randomized into following groups: 5/6(A/I) group, 5/6(A/I)+low-dose 5/6(A/I)+high-dose group. Another 12 that received sham...
<b><i>Introduction:</i></b> Malnutrition during a critical window of development in fetus or infant can result abnormal cardiac remodeling and function. It is uncertain whether the contribution these effects continues to impact function adults over course several decades growth. Our study examined early Chinese famine exposure on remodeling, left ventricular (LV) diastolic function, LV systolic adults. <b><i>Methods:</i></b> Participants at...
Objective To analyze the clinical characteristics and drug resistance of methicillin-resistant staphylococcus aureus(MRSA) to guide for reasonable use antibiotics. Methods A total 45 strains MRSA isolated from October 2015 March 2016 were collected antibiotics. Results A isolated, accounting 48.91% aureus separated. Antimicrobial resistant rates penicillin, oxacillin was 100%. All isolates sensitive quinupristin-dalfopristin, linezolid, vancomycin, tigecycline, furadantin....
Abstract Background: Azithromycin, widely used in recent years, can change the airway microbiota patients with chronic lung diseases. Little data exists regarding effects of azithromycin administration on among healthy adults. Therefore, we conducted a randomized, double-blind, placebo-controlled trial to assess process variation and re-establishment after exposure Methods: Forty-eight volunteers were enrolled randomly assigned into two groups. 500mg or placebo was administered once daily...