A5088966716- COVID-19 Clinical Research Studies
- Asthma and respiratory diseases
- Cancer Cells and Metastasis
- Reproductive System and Pregnancy
- SARS-CoV-2 and COVID-19 Research
- Fungal Infections and Studies
- Wnt/β-catenin signaling in development and cancer
- Infective Endocarditis Diagnosis and Management
- Infant Nutrition and Health
- Streptococcal Infections and Treatments
- Gut microbiota and health
- Long-Term Effects of COVID-19
- Cystic Fibrosis Research Advances
- IL-33, ST2, and ILC Pathways
- Connexins and lens biology
- Cervical Cancer and HPV Research
- COVID-19 and Mental Health
- Biochemical Acid Research Studies
- Endometriosis Research and Treatment
- Veterinary Oncology Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Appendicitis Diagnosis and Management
- Ear and Head Tumors
University of Newcastle Australia
2016-2024
Hunter Medical Research Institute
2019-2024
University of Guelph
2024
Raritan Bay Medical Center
2023
Maimonides Medical Center
2023
Army Medical College
2023
Thomas Jefferson University
2020-2022
Philadelphia College of Osteopathic Medicine
2022
Sidney Kimmel Cancer Center
2020-2022
Dow University of Health Sciences
2021-2022
COVID-19 is complicated by acute lung injury, and death in some individuals. It caused SARS-CoV-2 that requires the ACE2 receptor serine proteases to enter AEC. We determined what factors are associated with expression particularly patients asthma COPD.
Organoid technology has provided unique insights into human organ development, function, and diseases. Patient-derived organoids are increasingly used for drug screening, modeling rare disorders, designing regenerative therapies, understanding disease pathogenesis. However, the use of Matrigel to grow represents a major challenge in clinical translation organoid technology. is poorly defined mixture extracellular matrix proteins growth factors extracted from Engelbreth–Holm–Swarm mouse...
BackgroundHyperimmune anti-COVID-19 Intravenous Immunoglobulin (C-IVIG) is an unexplored therapy amidst the rapidly evolving spectrum of medical therapies for COVID-19 and expected to counter three most life-threatening consequences including lung injury by virus, cytokine storm sepsis.MethodsA single center, phase I/II, randomized controlled, single-blinded trial was conducted at Dow University Health Sciences, Karachi, Pakistan. Participants were infected individuals, classified as either...
Highlights•scRNA-seq analysis redefines vaginal epithelial cell hierarchy•Cd271+Axin2+ cells represent ovariectomy-resistant stem cells•These are responsible for homeostasis and regeneration•Cd271+Axin2+ cell-derived organoids mimic epithelium in vivoSummaryThe intact is essential women's reproductive health provides protection against HIV sexually transmitted infections. How this maintains itself remains poorly understood. Here, we used single-cell RNA sequencing (RNA-seq) to define the...
This study assesses the feasibility of producing hyperimmune anti-COVID-19 intravenously administrable immunoglobulin (C-IVIG) from pooled convalescent plasma (PCP) to provide a safe and effective passive immunization treatment option for COVID-19.
Abstract Background and Objective Severe asthma is a heterogeneous disease with subtype classification according to dominant airway infiltrates, including eosinophilic (Type 2 high), or non‐eosinophilic asthma. Non‐eosinophilic further divided into paucigranulocytic neutrophilic characterized by elevated neutrophils, mixed Type 1 17 cytokines in the airways. has few effective treatments many patients do not qualify for biologic therapies. The cystic fibrosis transmembrane conductance...
Healthy vaginal epithelium is essential for normal reproductive functions and protects against infectious diseases. Here, we present a protocol developing mouse organoids from single epithelial cells. These recapitulate both functional structural characteristics of vagina in situ. This model powerful tool investigating how microbiome or chemicals contraceptives personal hygiene products interact with stem cells alter the dynamics, which will lead to new insights into pathogenesis For...
Appendicular central osteosarcoma (OSA) is a common and highly aggressive tumour in dogs. Metastatic disease to the lungs even with chemotherapy prognosis generally poor. However, few cases survive well beyond reported median survival times. Current methods, including histologic grading schemes, have fallen short their ability predict clinical outcome. MicroRNAs (miRNAs) are small molecules present all tissues bodily fluids dysregulated cancer. Previous studies demonstrated diagnostic...
// Manish Kumar 1 , Joshua Atkins Murray Cairns Ayesha Ali and Pradeep S. Tanwar School of Biomedical Sciences Pharmacy, University Newcastle, Callaghan, New South Wales, Australia Correspondence to: Tanwar, email: Keywords : Wnt, βcatenin, spermatgonia, testicular cancer, fertility, Gerotarget Received October 05, 2016 Accepted December 06, Published 15, Abstract Dysregulated Wnt signalling is associated with human infertility cancer. However, the role in male germ cells remains poorly...
Basal cell and cutaneous squamous carcinoma are common malignancies (keratinocyte carcinomas [KCs]). Surgical resection is the standard of care. Radiation using high-dose rate brachytherapy (HDR-BT) may serve as a superior alternative where surgical scars be cosmetic concern or in elderly patients with significant comorbidity. We aim to describe clinical outcomes well posttreatment radiation toxicities associated HDR-BT who were treated for KCs face.Patients from 2015 2018 included study....
Abstract Cardiac implantable electronic device (CIED) leads can cause central venous stenosis (CVS). In addition, these devices get infected. Both are critically important considerations in patients with chronic kidney disease (CKD) for at least two reasons: (i) veins serve as the final pathway should need an arteriovenous access to provide dialysis therapy; and (ii) presence of renal failure increases risk CIED infection. this analysis, we investigated prevalence well degree harboring a...
Abstract Rationale COVID-19 is complicated by acute lung injury, and death in some individuals. It caused SARS-CoV-2 that requires the ACE2 receptor serine proteases to enter airway epithelial cells (AECs). Objective To determine what factors are associated with expression particularly patients asthma chronic obstructive pulmonary disease (COPD). Methods We obtained upper lower AECs from 145 people two independent cohorts, aged 2-89, Newcastle (n=115), Perth (n= 30) Australia. The cohort was...
Summary Severe lower respiratory infection (sLRI) are a major cause of infant morbidity and mortality, predispose to later chronic diseases such as asthma. Poor maternal diet during pregnancy is risk factor for sLRI in the offspring. Here we demonstrate mice that low-fibre (LFD) disrupts plasmacytoid conventional dendritic cell (DC) hematopoiesis offspring, predisposing subsequent The LFD alters composition milk microbiome assembling gut microbiome, ablating induction developmental wave...
Journal of Pharmaceutical Research International (ISSN: 2456-9119) is dedicated to publish high quality papers in all areas pharmaceutical Science including drugs, community pharmacy, hospital clinical compounding consultant internet veterinary nuclear military pharmacy informatics, pharmaceutics, medicinal chemistry, pharmacognosy, pharmacotherapy, pharmacodynamics, pharmacokinetics, pharmacology, neuropharmacology, psychopharmacology, pharmacogenetics, pharmacogenomics,...
Abstract Real-time quantitative PCR (RT-qPCR) is a widely used method for quantifying microRNA (miRNA) expression, but its accuracy depends on appropriate normalization. RT-qPCR susceptible to technical variation from several sources, including sample collection and storage, miRNA quantity/quality, extraction amplification efficiencies. Normalization corrects these factors, theoretically leaving behind only biological variation. With growing interest in miRNAs as biomarkers the diagnosis...
Abstract Background COVID-19 poses a global health challenge with more than 325 million cumulative cases and above 5 deaths reported till January 17, 2022, by the World Health Organization. Several potential treatments to treat are under clinical trials including antivirals, steroids, immunomodulators, non-specific IVIG, monoclonal antibodies, passive immunization through convalescent plasma. The need produce anti-COVID-19 IVIG therapy must be continued, alongside current treatment...
Group A streptococcus (GAS) is known to cause many different kinds of infections, including invasive pneumonia in rare cases. When it the causative agent, associated with a more severe disease course, but can often be adequately treated if caught early enough. We hereby present case 32-year-old male no past medical history who presented fever, hemoptysis, and tachycardia. Laboratory results showed leukocytosis, hyponatremia, mild transaminitis, elevated creatine kinase. Initial imaging...
The aim of the study was to observe effects immobilization on histomorphology rats’ intervertebral disc (IVD) and protective widely used neutraceuticals, Omega 3 fatty acids Co-enzyme Q 10 (CoQ10) it. animal experimental carried out in National Institute Health, Islamabad collaboration with Anatomy Department, Army Medical College, Rawalpindi. Forty Sprague Dawley rats, weighing 250-300g, were chosen grouped into 4 equal sets. Control group A fed normal lab diet. In B, along diet, an...