A5051645906- Epilepsy research and treatment
- Traumatic Brain Injury Research
- Vascular Malformations Diagnosis and Treatment
- Optical Imaging and Spectroscopy Techniques
- Intracranial Aneurysms: Treatment and Complications
- Functional Brain Connectivity Studies
- Neurological disorders and treatments
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Pharmacological Effects and Toxicity Studies
- Treatment of Major Depression
- Memory and Neural Mechanisms
- EEG and Brain-Computer Interfaces
- Lipid Membrane Structure and Behavior
- Psychosomatic Disorders and Their Treatments
- Cerebral Venous Sinus Thrombosis
- Cerebrovascular and Carotid Artery Diseases
- Transcranial Magnetic Stimulation Studies
- Neuroblastoma Research and Treatments
- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- Glioma Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Spatial Neglect and Hemispheric Dysfunction
VA West Los Angeles Medical Center
2024
University of Louisville
2024
VA Greater Los Angeles Healthcare System
2009-2023
Michigan State University
2022
University of California, Los Angeles
2002-2020
University of Colorado Hospital
2018
University of Colorado Denver
2018
Johns Hopkins University
2011-2015
National Center on Addiction and Substance Abuse at Columbia University
2015
Johns Hopkins Hospital
2011-2013
Abstract The neurophysiological mechanisms in the human amygdala that underlie post-traumatic stress disorder (PTSD) remain poorly understood. In a first-of-its-kind pilot study, we recorded intracranial electroencephalographic data longitudinally (over one year) two male individuals with electrodes implanted for management of treatment-resistant PTSD (TR-PTSD) under clinical trial NCT04152993. To determine electrophysiological signatures related to emotionally aversive and clinically...
Deep brain stimulation (DBS) holds promise for neuropsychiatric conditions where imbalance in network activity contributes to symptoms. Treatment-resistant Combat post-traumatic stress disorder (TR-PTSD) is a highly morbid condition and 50% of PTSD sufferers fail recover despite psychotherapy or pharmacotherapy. Reminder-triggered symptoms may arise from inadequate top-down ventromedial prefrontal cortex (vmPFC) control amygdala reactivity. Here, we report long-term data on two TR-PTSD...
Status epilepticus (SE) describes an enduring epileptic state during which seizures are unremitting and tend to be self-perpetuating. We describe the clinical phases of generalized convulsive SE, impending established subtle SE. discuss physiological biochemical cascades characterize self-sustaining SE (SSSE) in animal models. At transition from single SSSE, GABAA (gamma-aminobutyric acid) receptors move synaptic membrane cytoplasm, where they functionally inactive. This reduces number...
Combat post-traumatic stress disorder (PTSD) involves significant suffering, impairments in social and occupational functioning, substance use medical comorbidity, increased mortality from suicide other causes. Many veterans continue to suffer despite current treatments. Deep brain stimulation (DBS) has shown promise refractory movement disorders, depression obsessive-compulsive disorder, with deep targets chosen by integration of clinical neuroimaging literature. The basolateral amygdala...
Cortical spreading depression (CSD) is an important disease model for migraine and cerebral ischemia. In this study, we exploit the high temporal spatial resolution of optical imaging to characterize perfusion-dependent -independent changes in response CSD investigate etiology reflectance during CSD. experiment, characterized at wavelengths that emphasize perfusion-related (610 550 nm), compared these results with 850 nm blood volume data. Blood were recorded using intravascular fluorescent...
Linear relationships between synaptic activity and hemodynamic responses are critically dependent on functional signal etiology paradigm. To investigate these relationships, we simultaneously measured local field potentials (FPs) optical intrinsic signals in rat somatosensory cortex while delivering a small number of electrical pulses to the hindpaw with varied stimulus intensity, number, interstimulus interval. We used 570 610 nm estimate cerebral blood volume (CBV) oxygenation,...
<h3>Objective:</h3> Spinal digital subtraction angiography (SpDSA) continues to be the imaging gold standard for evaluation of spinal cord vascular disorders. The safety this procedure has a poor historical reputation and there are few current reports on complication rates. We hypothesized that modern SpDSA can performed with an acceptably low risk iatrogenic complications. <h3>Methods:</h3> In retrospective series, we reviewed 302 consecutive angiograms during 10-year period at our...
Mammalian vestibular organs have two types of hair cell, type I and II, which differ morphologically electrophysiologically. Type cells alone express an outwardly rectifying current, IK,L, activates at relatively negative voltages. We used whole cell patch configurations to studyI K,L in isolated from the sensory epithelia rat semicircular canals. K,Lwas potassium selective, blocked by 4-aminopyridine, permeable internal cesium. It activated with sigmoidal kinetics was half-maximally −74.5 ±...
Posttraumatic epilepsy (PTE) is a major long-term complication of traumatic brain injury (TBI). PTE usually develops within 5 years head injury. The risk for developing varies with TBI type. Both Korean and Vietnam war veterans penetrating had 53% PTE. between 10% 25% in combat-associated closed-head trauma positive imaging about 5% moderately severe without finding. We do not know the among Operation Iraqi Freedom/Operation Enduring Freedom minimal because blast exposure.Partial seizures...
The amygdala plays a critical role in emotion regulation. It could prove to be an effective neuromodulation target the treatment of psychiatric conditions characterized by failure extinction. We aim describe our targeting technique, and intra-operative post-operative electrodiagnostic findings associated with placement deep brain stimulation (DBS) electrodes amygdala. used transfrontal approach implant DBS basolateral nucleus (BLn) patient suffering from severe post-traumatic stress...
<b><i>Article abstract</i></b> The authors studied seizure activity with optical intrinsic signal (OIS) imaging in a rat model. OIS, which measures vascular and metabolic effects associated neuronal activity, showed significant cortical reflectance changes from penicillin-induced seizures, correlated well EEG epileptiform discharges. Furthermore, OIS often preceded initial spikes. These observations suggest that is coupled may provide sensitive cues for detection.
Cortical spreading depression (CSD) was imaged in vivo a rodent model with optical intrinsic signals (OIS). This is the first study to identify triphasic OIS response and characterize rate timing of response. The initial phase had highly uniform wavefront, which spread at characteristic CSD, 3.5 mm/min. Later phases were more diffuse inhomogeneous. Blood volume changes, measured intravascular fluorescent dye, correlated time location later reponse. suggests that inhomogeneity late may be due...
Penetrating traumatic brain injury (TBI) is a well-established risk factor for post-traumatic epilepsy (PTE). However, many veterans in Operation Enduring Freedom (OEF) and Iraqi (OIF) who suffer from TBI do so blast injury, its consequences are not fully known. Two neurologists performed chart review to describe patterns of health care among all 16 OEF/OIF at the VA Greater Los Angeles Healthcare System were assigned an outpatient diagnosis both 2008–2009. All Veterans male, mean age was 30...
The case history is described of a patient referred to our institution with facial nerve palsy following embolization middle cranial fossa dural arteriovenous fistula using ethylene vinyl alcohol copolymer (EVOH). Facial decompression was performed which showed evidence extensive penetration EVOH into the vasa nervosa nerve. debilitating complication that can be avoided by attention lower arterial supply during careful procedural planning and consideration alternative strategies for...
Accurate localization of complex human experiences such as emotions, dreaming, creativity, and consciousness to specific cerebral structures or neural networks has remained elusive despite technological advances. We report the use acute deep brain stimulation evoke behavioral emotional effects by applying electrical at various voltage strengths basolateral central subnuclei amygdala in addition head hippocampus for 2 subjects with medically refractory post-traumatic stress disorder. Our...
The basolateral amygdala (BLA) forms a triad with the medial prefrontal cortex (mPFC) and hippocampus (HPC) to process incoming stimuli orchestrate emotional responses [[1]Calhoon GG Tye KM Resolving neural circuits of anxiety.Nat Neurosci. 2015; : 1394-1404https://doi.org/10.1038/nn.4101Crossref PubMed Scopus (270) Google Scholar]. In post-traumatic stress disorder (PTSD), dysfunction in this is characterized by deficit mPFC inhibition BLA [[2]Groblewski PA Stafford JM When fails:...
"An ounce of prevention is worth a pound cure." —Benjamin Franklin, 1736 Aneurysmal subarachnoid hemorrhage (aSAH) devastating subtype stroke affecting up to 30,000 individuals annually in the United States.1 Despite significant advances diagnosis and treatment, aSAH associated with an 50% mortality rate permanent disability 30% survivors.1,2 Whenever patients survive ictus aneurysm rupture, they are at risk rebleeding delayed cerebral ischemia (DCI). Although historically common, aneurysmal...