A5103186554- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Angiogenesis and VEGF in Cancer
- Glioma Diagnosis and Treatment
- Thermal Regulation in Medicine
- Cell Adhesion Molecules Research
- CRISPR and Genetic Engineering
- Extracellular vesicles in disease
- Virus-based gene therapy research
- Advanced Memory and Neural Computing
- Protease and Inhibitor Mechanisms
- Force Microscopy Techniques and Applications
- Cancer Research and Treatments
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer, Stress, Anesthesia, and Immune Response
- Meningioma and schwannoma management
- Blood Coagulation and Thrombosis Mechanisms
- Cellular Mechanics and Interactions
- Electrochemical Analysis and Applications
- RNA Interference and Gene Delivery
- Laser Applications in Dentistry and Medicine
- Cancer-related gene regulation
- Microbial infections and disease research
CEA Grenoble
2012-2024
CEA LETI
2012-2024
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2011-2024
Clinatec
2011-2024
Université Grenoble Alpes
2006-2024
Centre National de la Recherche Scientifique
2020
Institut de Recherche de Chimie Paris
2020
Université Paris Sciences et Lettres
2020
Chimie ParisTech
2020
Institut polytechnique de Grenoble
2016-2019
A wireless 64-channel ElectroCorticoGram (ECoG) recording implant named WIMAGINE has been designed for various clinical applications. The device is aimed at interfacing a cortical electrode array to an external computer neural and control This active implantable medical able record activity on 64 electrodes with selectable gain sampling frequency, less than 1 μV(RMS) input referred noise in the [0.5 Hz - 300 Hz] band. It powered remotely through inductive link 13.56 MHz which provides up 100...
Previous experimental studies have documented the neuroprotection of damaged or diseased cells after applying, from outside brain, near-infrared light (NIr) to brain by using external light-emitting diodes (LEDs) laser devices. In present study, authors describe an effective and reliable surgical method applying inside NIr brain. They developed a novel internal device that delivers regions very close target cells. suggest this will be useful in within large human particularly if deep...
Abstract Background We have shown previously that near-infrared light (NIr) treatment or photobiomodulation neuroprotects dopaminergic cells in substantia nigra pars compacta (SNc) from degeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Balb/c albino mice, a well-known model for Parkinson’s disease. The present study explores whether NIr offers neuroprotection to these C57BL/6 pigmented mice. In addition, we examine influences behavioural activity both strains after...
It is now well established that the mechanical environment of cells in tissues deeply impacts cellular fate, including life cycle, differentiation and tumor progression. Designs biomaterials already include control parameters, general, their main focus to rheological properties at a macroscopic scale. However, recent studies have demonstrated can stress below micron scale, therefore could possibly respond this In context, probing physiological environments subcellular scales becoming...
Three methylated bases, 5‐methylcytosine, N4‐methylcytosine and N6‐methyladenine (m6A), can be found in DNA. However, to date, only 5‐methylcytosine has been detected mammalian genomes. To reinvestigate the presence of m6A DNA, we used a highly sensitive method capable detecting one N6‐methyldeoxyadenosine per million nucleosides. Our results suggest that total mouse genome contains, if any, less than 10 3 m6A. Experiments were next performed on PRED28, putative N6‐DNA methyltransferase. The...
OBJECTIVE Wireless technology is a novel tool for the transmission of cortical signals. electrocorticography (ECoG) aims to improve safety and diagnostic gain procedures requiring invasive localization seizure foci also provide long-term recording brain activity brain-computer interfaces (BCIs). However, no wireless devices aimed at these clinical applications are currently available. The authors present application fully implantable externally rechargeable neural prosthesis providing ECoG...
New molecular profiling technologies can aid in analysis of small pathologic samples obtained by minimally invasive biopsy and may enable the discovery key biomarkers synergistic with anatomopathologic related to prognosis, therapeutic response, innovative target validation. Thus proteomic at histologic level healthy settings is a major issue field clinical proteomics.We used surface-enhanced laser desorption ionization-time-of-flight mass spectrometry (SELDI-TOF MS) technology surface...
Circulating autoantibodies to self-antigens overexpressed by cancer cells are common in patients. As specific proteins expressed during neoangiogenesis, a similar phenomenon might occur with particular antigens of tumour vessels. Collagen XVIII, from which endostatin is cleaved, highly the perivascular basement membrane tumour-associated blood vessels and have been reported The present study analyses incidence naturally occurring sera breast patients their relation serum levels patient...
Tissue factor pathway inhibitor (TFPI) is a plasma Kunitz-type serine protease that mainly known for its inhibition of tissue factor-mediated coagulation. In addition to anticoagulant properties, emerging data show TFPI may also regulate endothelial cell functions via non-haemostatic pathway. this work we demonstrate at concentrations within the physiological range, inhibits both migration and their differentiation into capillary-like structures in vitro. These effects were specific cells...
This paper deals with the long-term preclinical validation of WIMAGINE® (Wireless Implantable Multi-channel Acquisition system for Generic Interface NEurons), a 64-channel wireless implantable recorder that measures electrical activity at cortical surface (electrocorticography, ECoG). The implant was designed chronic neuronal signal acquisition, to be used e.g. as an intracranial Brain-Computer (BCI) severely motor-impaired patients. Due size and shape WIMAGINE®, sheep appeared best animal...
The goal of the CLINATEC® Brain Computer Interface (BCI) Project is to improve tetraplegic subjects' quality life by allowing them interact with their environment through control effectors, such as an exoskeleton. BCI platform based on a wireless 64-channel ElectroCorticoGram (ECoG) recording implant WIMAGINE®, designed for long-term clinical application, and software associated 4-limb exoskeleton EMY (Enhancing MobilitY). Innovative ECoG signal decoding algorithms will allow subject's brain...
Focal cooling is emerging as a relevant therapy for drug-resistant epilepsy (DRE). However, we lack data on its effectiveness in controlling seizures that originate deep-seated areas like the hippocampus. We present thermoelectric solution focal brain specifically targets these structures.
The goal of this study was to evaluate the long-term behavior surface electrode through electrochemical characterization and follow-up implanted parylene/platinum microelectrodes.To aim, we designed manufactured specific planar electrodes for cortical implantation a rat model. This work included in INTENSE® project, one goals which prove feasibility selective neural recording or stimulation with cuff around vagus nerve.After 12-week model, can report that these microelectrodes have withstood...