A5032195012- Head and Neck Cancer Studies
- Cancer survivorship and care
- Family Support in Illness
- Palliative Care and End-of-Life Issues
- Oral Health Pathology and Treatment
- Cancer Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Oral health in cancer treatment
- Innovations in Medical Education
- Probiotics and Fermented Foods
- Global Cancer Incidence and Screening
- Patient-Provider Communication in Healthcare
- Dental Education, Practice, Research
- Microbial Metabolites in Food Biotechnology
- Oral microbiology and periodontitis research
- Gut microbiota and health
- Salivary Gland Disorders and Functions
- Advanced Proteomics Techniques and Applications
- Evaluation of Teaching Practices
- Problem and Project Based Learning
- Alzheimer's disease research and treatments
- Migraine and Headache Studies
- Cleft Lip and Palate Research
- Migration, Health and Trauma
- Animal Disease Management and Epidemiology
Southmead Hospital
2025
Cork University Hospital
2014-2024
University College Cork
2011-2024
Munster Technological University
2021-2022
RK University
2015-2016
Cork County Council
2012
West Midlands Police
2006
ABSTRACT Spray drying of skim milk was evaluated as a means preserving Lactobacillus paracasei NFBC 338 and salivarius UCC 118, which are human-derived strains with probiotic potential. Our initial experiments revealed that is considerably more heat resistant in 20% (wt/vol) than 118 is; the comparable decimal reduction times were 11.1 1.1 min, respectively, at 59°C. An air outlet temperature 80 to 85°C optimal for spray drying; these conditions resulted powders moisture contents 4.1 4.2%...
Brain-derived neurotrophic factor (BDNF) is of interest because its putative role in stress and psychiatric disorders. Maternal separation used as an animal model early-life irritable bowel syndrome (IBS). Animals exposed to the paradigm show altered gut function together with heightened levels arousal corticosterone. Some probiotic organisms have been shown be benefit IBS influence brain-gut axis. Our objective was investigate effects maternal on BDNF under basal conditions response...
Background and PurposesTo assess osteoradionecrosis (ORN) incidence in a population of Irish Head Neck cancer (HNC) patients, precipitating factors that may contribute to ORN development aid prevention.Materials MethodsReview 1050 HNC patients attending the Dental Oncology Clinic, CUDSH between 2010 2021 identified 47 cases ORN. Medical, dental radiotherapy records these forty-seven were retrospectively reviewed. Patient-, tumour-, treatment-related variables investigated association with...
This study demonstrates that exposure of log-phase Lactococcus lactis subsp. cremoris 712 cells to mildly acid conditions induces resistance normally lethal intensities environmental stresses such as acid, heat, NaCl, H2O2, and ethanol. The intracellular pH (pHi) played a major role in the induction this multistress response. pHi was dependent on extracellular (pHo) specific used reduce pHo. When resuspended fresh medium, were able maintain gradient even at pHo values resulted cell death....
In the search for new probiotics, 61 Lactobacillus spp. isolates, belonging to 12 species and isolated as dominant lactic acid bacteria from feces of healthy humans, were subjected a subtractive system in vitro analyses, which included desirable undesirable traits. Twenty-four isolates able grow 2% bovine bile, 13 grew acidified broth at pH 3.5 cysteine-containing MRS broth. Intrinsic resistance certain antimicrobial agents (cefoxitin, metronidazole, vancomycin) was observed most but...
There is a lack of research on the financial impacts that head and neck cancer has caregivers.To explore overall impact caregivers; to describe factors mitigate this impact.Interviews with 31 caregivers (mean time caring: 5.7 years).Head had considerable caregivers. It resulted in out pocket costs and/or their relative/friend often became under- or un-employed. Caregivers large debts ongoing expenses appeared be particularly vulnerable cancer-related pressures. Finance related psychological...
Aims: The aim of this work was to identify and select new probiotic strains among majority intestinal bifidobacterial species from healthy Spaniards. Methods Results: One hundred eighty isolates belonging seven Bifidobacterium were subjected a subtractive system in vitro analysis addressing beneficial undesirable traits. Approx. 45% the able grow 2% bovine bile, about 20% these grew at pH 3·5. Undesirable enzymatic activities, such as α‐chymotrypsin, β‐glucuronidase...
Abstract Objective Cancer survivors are susceptible to financial hardship. In head and neck cancer (HNC) survivors, we investigated (a) predictors for cancer‐related hardship (b) associations between health‐related quality of life (HRQoL). Methods We conducted a cross‐sectional study in HNC identified from the National Registry Ireland. HRQoL was based on Functional Assessment Therapy General (FACT‐G) plus Head Neck Module (FACT‐HN). (financial stress) assessed as household ability make ends...
An apparent "inverse" relationship exists between two seemingly unconnected conditions: Alzheimer's disease (AD) and cancer, despite sharing similar risk factors, like increased age obesity. AD is associated with amyloid beta (Aβ) plaques neurofibrillary tau tangles that cause neural degeneration; in contrast, characterised by enhanced cell survival proliferation. Apolipoprotein E (ApoE) the main lipoprotein found central nervous system via its high affinity receptors plays a...
Fear of recurrence (FOR) is a primary concern for both cancer survivors and their caregivers, yet little known about what care-related factors exacerbate this worry.This study aimed to establish the role stressors-as distinct from survivor characteristics-in predicting FOR in head neck caregivers.HNC survivor-caregiver dyads took part mailed survey. Survivors provided information on health quality life (using Functional Assessment Cancer Therapy Questionnaire). Caregivers sociodemographic...
Abstract Objective Active self‐management practices may help head and neck cancer (HNC) survivors to deal with challenges their physical, functional, social, psychological well‐being presented by HNC its treatment. This study investigates the factors perceived act as barriers active following primary Methods In this qualitative study, 27 identified through 4 designated centres in Ireland participated face‐to‐face semistructured interviews. Interviews were audio‐recorded, transcribed,...
Head and neck cancer (HNC) survivors encounter unique challenges following treatment. This study aimed to identify self-management strategies that HNC use overcome these posttreatment challenges.Twenty-seven individuals from 4 designated centres in Ireland were interviewed about helped them Interviews audio-recorded, transcribed, analysed using directed content analysis.Twenty strategy types (encompassing 77 specific strategies) identified. The most frequently used self-sustaining (used by...
Disease- and treatment-related consequences in Head Neck Cancer (HNC) can result psychological issues for which specialist support, dubbed psycho-oncology, is recommended. Health Social Care Professionals (HSCPs) function as a crucial link between survivors these services, through onward referral pathways. However, little known about HSCPs' perspectives on barriers to accessing psycho-oncology HNC. The current study sought investigate such perspectives.Eleven HSCPs from national cancer...