A5070696076- RNA modifications and cancer
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Nanoparticle-Based Drug Delivery
- MicroRNA in disease regulation
- Asthma and respiratory diseases
- Cancer, Lipids, and Metabolism
- Gout, Hyperuricemia, Uric Acid
- Pediatric health and respiratory diseases
- Liver Disease Diagnosis and Treatment
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- Drug-Induced Hepatotoxicity and Protection
- Lung Cancer Treatments and Mutations
- Allergic Rhinitis and Sensitization
- Peptidase Inhibition and Analysis
- Mosquito-borne diseases and control
- Advanced biosensing and bioanalysis techniques
- Immune Cell Function and Interaction
- Spectroscopy and Chemometric Analyses
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Cancer Cells and Metastasis
Shenyang Pharmaceutical University
2021-2025
Jiangsu University
2019-2025
Qingdao University
2019-2025
Qingdao Municipal Hospital
2019-2025
Huazhong Agricultural University
2019-2025
Shandong Provincial Hospital
2024-2025
Shandong First Medical University
2024-2025
Wuhan University
2025
Yueyang Hospital
2015-2024
Shanghai University of Traditional Chinese Medicine
2015-2024
Abstract Significant improvements in the outcome of non–small cell lung carcinoma (NSCLC) have been reported patients treated with epidermal growth factor receptor (EGFR) inhibitor, erlotinib. To discover biomarkers for enrichment who might benefit from treatment, a pharmacogenomic approach was used to identify gene signatures that may predict erlotinib activity using vitro model systems. Erlotinib sensitivity panel 42 NSCLC lines determined by EGFR-mediated proliferative potential, EGFR...
Activating mutations in receptor tyrosine kinases play a critical role oncogenesis. Despite evidence that Met kinase is deregulated human cancer, the of activating cancers other than renal papillary carcinoma has not been well defined. Here we report identification somatic intronic lead to an alternatively spliced transcript lung which encodes deletion juxtamembrane domain resulting loss Cbl E3-ligase binding. The mutant exhibits decreased ubiquitination and delayed down-regulation...
Abstract Co-delivery of chemotherapeutics and siRNA with different mechanisms in a single system is promising strategy for effective cancer therapy synergistic effects. In this study, triblock copolymer micelle was prepared based on the polymer N-succinyl chitosan–poly-L-lysine–palmitic acid (NSC–PLL–PA) to co-deliver doxorubicin (Dox) siRNA–P-glycoprotein (P-gp) (Dox–siRNA-micelle). Dox–siRNA-micelle unstable pH 5.3 medium than 7.4 medium, which corresponded vitro rapid release Dox acidic...
The epithelial-to-mesenchymal transition (EMT) program is critical for epithelial cell cancer progression and fibrotic diseases. FOXO1 influences a broad range of physiological pathological processes. However, the mechanism by which inhibits EMT not fully understood. In this study, we demonstrated that overexpression inhibited motility invasiveness in vitro lung metastasis vivo. addition, found couldreverse program. silencing siRNA hepatocellular carcinoma (HCC) lines enhanced expression...
The triglyceride glucose-body mass index (TyG-BMI) is recognized as a reliable surrogate for evaluating insulin resistance and an effective predictor of cardiovascular disease. However, the link between TyG-BMI adverse outcomes in heart failure (HF) patients remains unclear. This study examines correlation with long-term HF coronary disease (CHD).
Panobinostat (LBH589) is a highly potent deacetylase inhibitor that has demonstrated clinical efficacy in patients with advanced cutaneous T-cell lymphoma (CTCL). To gain better understanding of the compound activity this tumor type, we investigated cellular and molecular effects panobinostat using both vitro vivo models CTCL. All 4 tested CTCL cell lines exhibited very high sensitivity to panobinostat-induced growth inhibition. However, only 2 significant response cytotoxic panobinostat. In...
The efficient delivery of antitumor agents to tumor sites faces numerous obstacles, such as poor cellular uptake and slow intracellular drug release. In this regard, smart nanoparticles (NPs) that respond the unique microenvironment tissues have been widely used for delivery. study, novel charge-reversal reduction-responsive histidine-grafted chitosan-lipoic acid NPs (HCSL-NPs) were selected therapy breast cancer by enhancing cell internalization pH- reduction-triggered doxorubicin (DOX)...
Ovarian cancer is the leading cause of death in gynecological cancer. Cancer stem cells (CSCs) contribute to occurrence, progression and resistance. Small nucleolar RNAs (SnoRNAs), a class small molecule non-coding RNA, involve cell stemness tumorigenesis. In this study, we screened out SNORNAs related ovarian patient's prognosis by analyzing data 379 cases patients TCGA database, analyzed difference expression between OVCAR-3 (OV) sphere-forming (OS) OV cells. After overexpression or...
Zika virus (ZIKV) can be transmitted from mother to fetus during pregnancy, causing adverse fetal outcomes. Several studies have indicated that ZIKV damage the brain directly; however, whether ZIKV-induced maternal placental injury contributes outcomes is sparsely defined. Here, we demonstrated causes pyroptosis of cells by activating executor gasdermin E (GSDME) in vitro and vivo. Mechanistically, TNF-α release induced upon recognition viral genomic RNA RIG-I, followed activation caspase-8...
Abstract Prevalence of heart failure (HF) continues to rise over time and is a global difficult problem; new drug targets are urgently needed. In recent years, pyroptosis confirmed promote cardiac remodelling HF. Echinacoside (ECH) natural phenylethanoid glycoside the major active component traditional Chinese medicine Cistanches Herba, which reported possess powerful anti‐oxidation anti‐inflammatory effects. addition, we previously that ECH reversed improved function, but effect on has not...
Multidrug resistance (MDR) remains a critical bottleneck in successful treatment of osteosarcoma (OS). Luteolin is flavonoid compound that has been verified to increase the sensitivity antineoplastic drugs many tumors. However, its roles reversing MDR OS and potential underlying mechanisms remain largely unknown. In this study, we demonstrated luteolin enhances cellular chemosensitivity doxorubicin cisplatin both cells xenograft models, it could miR-384 level downregulate PTN expression....
Abstract: Multidrug resistance (MDR) is a major obstacle for the clinical therapy of malignant human cancers. The discovery RNA interference provides efficient gene silencing within tumor cells reversing MDR. In this study, new "binary polymer" low-density lipoprotein– N -succinyl chitosan–cystamine–urocanic acid (LDL–NSC–SS–UA) with dual pH/redox sensitivity and targeting effect was synthesized co-delivery breast cancer protein small interfering (siRNA) paclitaxel (PTX). vivo, co-delivering...
Postoperative cognitive dysfunction (POCD), common in elderly patients, refers to a decline function following surgery, which may persist or even evolve into Alzheimer's disease (AD). Despite great efforts, the mechanism of POCD remains unclear. In present study, we tested hypothesis that Toll-like receptor 4 (TLR4) on microglia contributes POCD. Shortly after aged rats demonstrated significant deficits memory and learning, accompanied by activation microglia, marked upregulation TLR4...
Curcumin was recently discovered to strengthen immune response through multiple mechanisms. Cytotoxic CD8+ T-cells play a critical role in modulating anticancer response, but is severely restricted by T-cell exhaustion. Bladder carcinomas express PD-L1 and can abrogate response. Thus, we hypothesized that bisdemethoxycurcumin, natural dimethoxy derivative of curcumin, may provide favorable environment for against bladder cancer when used combination with α-PD-L1 antibody. Immunocompetent...
Abstract: In this study, harmine liposomes (HM-lip) were prepared through the thin-film hydration–pH-gradient method and then coated with N -trimethyl chitosan (TMC). Particle size, zeta potential, entrapment efficiency, in vitro release of HM-lip TMC-coated (TMC-HM-lip) also determined. Sprague Dawley rats further used to investigate pharmacokinetics vivo. Retention behavior mouse gastrointestinal tract (GIT) was studied high-performance liquid chromatography near-infrared imaging....
Abstract Increasing evidence has verified that small nucleolar RNAs (snoRNAs) play significant roles in tumorigenesis and exhibit prognostic value clinical practice. In the study, we analysed expression profile relevance of snoRNAs from TCGA database including 530 ccRCC (clear cell renal carcinoma) 72 control cases. By using univariate multivariate Cox analysis, established a six‐snoRNA signature divided patients into high‐risk or low‐risk groups. We found group had significantly shorter...
Lung adenocarcinoma (LUAD) is associated with poor prognosis. Identifying novel cancer targets and helpful therapeutic strategies remains a serious clinical challenge. This study detected differentially expressed genes in The Cancer Genome Atlas (TCGA) LUAD data collection. We also identified predictive DNA biomarker, G protein-coupled receptor 37 (GPR37), which was verified as prognostic biomarker critical role tumor progression. In human specimens microarray analyses, we determined that...
This study took the wheat grown in experimental area of Jiangsu Academy Agricultural Sciences as research object and used unmanned aerial vehicle (UAV) to carry Rededge-MX multispectral camera obtain scab image with different spatial resolutions (1.44 cm, 2.11 3.47 4.96 6.34 7.67 cm). The vegetation indexes (VIs) texture features (TFs) extracted from UAV were screened for high correlation disease index (DI) investigate impact resolution on accuracy monitoring. Finally, best monitoring was...