A5101625733- Inflammasome and immune disorders
- Gout, Hyperuricemia, Uric Acid
- Heme Oxygenase-1 and Carbon Monoxide
- Ocular Surface and Contact Lens
- Chronic Obstructive Pulmonary Disease (COPD) Research
- IL-33, ST2, and ILC Pathways
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Plant Molecular Biology Research
- Cancer, Hypoxia, and Metabolism
- Corneal Surgery and Treatments
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Mosquito-borne diseases and control
- Respiratory Support and Mechanisms
- Corneal surgery and disorders
- Plant nutrient uptake and metabolism
- Lipid metabolism and disorders
- Viral Infections and Immunology Research
- Immune Response and Inflammation
- EFL/ESL Teaching and Learning
- Cancer Research and Treatments
- Vitamin D Research Studies
- Chromatography in Natural Products
Fudan University
2009-2025
Huashan Hospital
2025
Guiyang Medical University
2024-2025
Affiliated Hospital of Guizhou Medical University
2024-2025
Second Affiliated Hospital of Nanchang University
2022-2024
Nanchang University
2022-2024
Shanghai Jiao Tong University
2022-2024
University of Saint Joseph
2024
Shantou University
2024
Zhongshan Hospital
2013-2023
The gradual aging of the global population has led to a surge in age-related diseases, which seriously threaten human health. Researchers are dedicated understanding and coping with complexities aging, constantly uncovering substances mechanism related like chronic low-grade inflammation. NOD-like receptor protein 3 (NLRP3), key regulator innate immune response, recognizes molecular patterns associated pathogens injury, initiating an intrinsic inflammatory response. Dysfunctional NLRP3 is...
The NLRP3 inflammasome is a multiprotein oligomer responsible for activation of the inflammatory response by promoting maturation and secretion pro-inflammatory cytokines IL-1β IL-18. Dysregulation this has been linked to several autoimmune diseases, indicating that tightly regulated prevent aberrant activation. regulation remains unclear. Here, we report identification vitamin D receptor (VDR) as negative regulator oligomerization VDR can physically bind block association with BRCC3. When...
Chemotherapy resistance is one of the most common causes death among patients with ovarian cancer, and identifying novel antitumor agents a priority. Here, we report that molecule 2‐(anaphthoyl)ethyl‐trimethylammonium iodide (α‐NETA) induces epithelial cancer (EOC) cell pyroptosis through gesdermin‐d (GSDMD)/caspase‐4 pathway. Furthermore, Cell Counting Kit‐8 fluorescence‐activated sorting analysis showed α‐NETA treatment led to in different lines, including Ho8910, Ho8910PM, A2780....
Inflammation is a defense mechanism that can protect the host against microbe invasion. A proper inflammatory response maintain homeostasis, but continuous inflammation cause many chronic diseases. To properly treat disorders, molecular mechanisms underlying development of need to be fully elucidated. Pyroptosis an inflammation-related cell death program, different from other types death. plays crucial roles in infections through release proinflammatory cytokines and lysis. Accumulating...
Inflammasome activation in response to elevated tear osmolarity behaves as an initial signal dry eye-related corneal inflammation. Pyroptosis is another prominent consequence of inflammasome activation, which featured by gasdermin D (GSDMD)-driven cell lysis. This study aims explore the role pyroptosis eye, and also verify if calcitriol, a potential therapeutic agent for has certain effects against hyperosmotic stress (HS)-induced human epithelial cells (iHCECs) underlying mechanism.The...
Next generation sequencing (NGS) technologies have revolutionized the genomics field and are becoming more commonplace for identification of human infectious diseases. However, due to low abundance viral nucleic acids (NAs) in relation host, using direct NGS often lacks sufficient sensitivity. Here, we describe an approach based on two complementary enrichment strategies that significantly improves sensitivity NGS-based virus identification. To start, developed sets DNA probes enrich NAs...
Viruses depend on host cellular metabolism to provide the energy and biosynthetic building blocks required for their replication. In this study, we observed that influenza A virus (H1N1), a single-stranded, negative-sense RNA with an eight-segmented genome, enhanced glycolysis both in mouse lung tissues human epithelial (A549) cells. detail, expression of hexokinase 2 (HK2), first enzyme glycolysis, was upregulated H1N1-infected A549 cells, pyruvate kinase M2 (PKM2) dehydrogenase 3 (PDK3)...
Silica is an essential substrate of various materials, and inhaling silica induces pulmonary diseases potentially associated with macrophage pyroptosis. Utilizing micro- nano- sizes, we explored the role pyroptosis in silica-induced inflammation. Under transmission electron microscopy, found that internalization nanoparticle induced membrane rupture increased number intracellular vacuoles, both sizes could suppress cell viability proliferation. Also, silica-exposed macrophages generated...
Abstract Prevalence of heart failure (HF) continues to rise over time and is a global difficult problem; new drug targets are urgently needed. In recent years, pyroptosis confirmed promote cardiac remodelling HF. Echinacoside (ECH) natural phenylethanoid glycoside the major active component traditional Chinese medicine Cistanches Herba, which reported possess powerful anti‐oxidation anti‐inflammatory effects. addition, we previously that ECH reversed improved function, but effect on has not...
Silica nanoparticle (SiNP) exposure induces severe pulmonary inflammation and fibrosis, but the pathogenesis remains unclear, effective therapies are currently lacking. To explore mechanism underlying SiNPs-induced we constructed in vivo silica animal models vitro of silica-induced macrophage pyroptosis fibroblast transdifferentiation. We found that SiNP elicits upregulation proteins associated with pyroptosis, including NLRP3, ASC, IL-1β, GSDMD, while immunofluorescence staining...
Virus reprogramming of host cellular function is a critical strategy for viral survival and replication. A better understanding virus-host interaction may provide new potential avenues the treatment diseases. It has been reported that hypoxia-inducible factor-1 (HIF-1) pathway activated by range pathogens via different mechanisms, but impact Influenza virus on HIF-1 signaling still unclear. In this study, we observed H1N1 infection stabilized HIF-1α under normoxic conditions. detail, did not...
Abstract Background Rifaquizinone (RFQ, TNP-2092) is a novel multitargeting antibacterial agent under clinical development for the treatment of acute bacterial skin and structure infections (ABSSSIs) prosthetic joint (PJIs). This study assessed safety, tolerance, pharmacokinetics (PK) RFQ injection in healthy Chinese participants compared PK profile between US population. Methods A randomized was conducted single center China (NCT06394518). Thirty-two eligible were enrolled into 3 cohorts,...
Many flaviviruses including the Dengue virus (DENV), Zika (ZIKV), West Nile virus, Yellow Fever and Japanese encephalitis are significant human pathogens, unfortunately without any specific therapy. Here, we demonstrate that methylene blue, an FDA-approved drug, is a broad-spectrum potent antiviral against both in vitro vivo. We found blue can considerably inhibit interactions between viral protease NS3 its NS2B co-factor, activity, growth, protect 3D mini-brain organoids from ZIKV...
Background: The objective of the study is to develop a scoring system for predicting 90-day re-exacerbation in hospitalized patients with acute exacerbations chronic obstructive pulmonary disease (AECOPD). Methods: A total 176 consecutive AECOPD were included. sociodemographic characteristics, status before exacerbation (AE), presentations and treatment current AE, 90 days after discharge from hospital collected. Results: rate was 48.9% (86 out 176). It associated degree lung function...
Introduction: Silica nanoparticles (SiNPs) are one of the most widely used inorganic nanomaterials, and exposure to SiNP has been demonstrated induce pulmonary inflammation, primarily promoted by NLRP3-mediated macrophage pyroptosis. However, mechanisms underlying activation NLRP3 signaling complex, whether cathepsin B (CTSB), an enzyme released ruptured lysosome, could trigger assembly is controversial. Methods: To further characterize role CTSB in silica-induced pyroptosis, we conducted...
Emerging research has revealed that the activation of NLR family pyrin domain containing 3 (NLRP3) inflammasomes contribute to development inflammatory and neuropathic pains. In addition, microglia are involved in central nervous system (CNS) pain conduction. However, relationship between NLRP3 inflammasome dental conduction is yet be established. Therefore, this study aimed investigate roles P2X7 NLRP3/Caspase-1 (CASP1) caused by pulpitis using a rat experimental model. We discovered...
In addition to the significant role in physical activity, skeletal muscle also contributes health through storage and use of macronutrients associated with energy homeostasis. However, mechanisms regulating integrated metabolism are not well-defined. Here, we compared transcriptome from obese lean control subjects different species (human mouse) found that interferon regulatory factor 4 (IRF4), an inflammation-immune transcription factor, conservatively increased subjects. Thus, investigated...