A5040175361- Inflammasome and immune disorders
- Immune cells in cancer
- Immune Cell Function and Interaction
- Heme Oxygenase-1 and Carbon Monoxide
- Phagocytosis and Immune Regulation
- IL-33, ST2, and ILC Pathways
- Adenosine and Purinergic Signaling
- Bipolar Disorder and Treatment
- Sphingolipid Metabolism and Signaling
- Advanced Glycation End Products research
- Psoriasis: Treatment and Pathogenesis
- Vitamin D Research Studies
- Diet and metabolism studies
- Urticaria and Related Conditions
- Animal Nutrition and Physiology
- Eosinophilic Esophagitis
- Gut microbiota and health
- Autophagy in Disease and Therapy
Westlake University
2023-2024
Nanjing Medical University
2017-2023
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2023
Southwest University
2021
The NLRP3 inflammasome is a multiprotein oligomer responsible for activation of the inflammatory response by promoting maturation and secretion pro-inflammatory cytokines IL-1β IL-18. Dysregulation this has been linked to several autoimmune diseases, indicating that tightly regulated prevent aberrant activation. regulation remains unclear. Here, we report identification vitamin D receptor (VDR) as negative regulator oligomerization VDR can physically bind block association with BRCC3. When...
Parkin, an E3 ubiquitin ligase, plays essential role in mitophagy. Emerging evidence indicates that mitophagy is involved various processes closely related to immune diseases, including inflammatory bowel diseases (IBD). Here, the authors show Parkin increases occurrence of colitis and severe inflammation. Deletion resulted marked reductions colonic inflammation exhibited high resistance DSS-induced colitis. Mechanism investigation indicated interacts with Vitamin D receptors (VDR), a...
1,25-Dihydroxyvitamin D [1,25(OH)2D3] is recognized as a key mediator of inflammatory diseases, including sepsis. Clinical studies demonstrate that 1,25 (OH)2D3 protects patients from sepsis, but clinical treatment with 1,25(OH)2D3 rare. In this study, we report has beneficial effects and improves the survival rate in LPS-induced mouse sepsis model by blocking secretion high-mobility group box 1 (HMGB1), late regulator HMGB1 attenuated 1,25(OH)2D3via translocation nucleus to cytoplasm...
Background and Aims: The purpose of this study was to determine the effects low protein diets with same Lys, Met + Cys, Thr, Trp levels as in high on fecal amino acid excretion apparent digestibility, ileal microbial acids composition weaned piglets. Methods: Fifty-four 21-day-old Duroc × Landrace Yorkshire piglets were randomly divided into three groups fed corn-soybean meal basal diets, which crude (CP) content 20% (H-CP), 17% (M-CP), 14% (L-CP), respectively. experiment included a 7-day...