A5087346958- Adipose Tissue and Metabolism
- Head and Neck Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Muscle metabolism and nutrition
- High Altitude and Hypoxia
- Diet and metabolism studies
- Exercise and Physiological Responses
- Metabolomics and Mass Spectrometry Studies
- Sarcoma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Metabolism, Diabetes, and Cancer
- PARP inhibition in cancer therapy
- Anesthesia and Sedative Agents
- Lung Cancer Treatments and Mutations
- Liver Disease Diagnosis and Treatment
- Dietary Effects on Health
- Gastrointestinal disorders and treatments
- Fibroblast Growth Factor Research
- Gut microbiota and health
- Genetics and Physical Performance
- Peptidase Inhibition and Analysis
- Veterinary Pharmacology and Anesthesia
- Biotin and Related Studies
- Cancer Risks and Factors
Sun Yat-sen University
2022-2025
Sun Yat-sen University Cancer Center
2022-2025
First Affiliated Hospital of Anhui Medical University
2023-2024
Anhui Medical University
2023-2024
Shenzhen Institutes of Advanced Technology
2024
Fudan University
2021-2024
Affiliated Hospital of Hebei University
2024
Shanghai University of Sport
2019-2023
Huashan Hospital
2023
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2021-2023
Importance Accurate staging is a fundamental step in treating patients with nasopharyngeal carcinoma (NPC) worldwide; this crucial not only for prognostication, but also guiding treatment decisions. The American Joint Committee on Cancer (AJCC)/Union International Control (UICC) tumor-node-metastasis (TNM) system the global language clinicians, researchers, and cancer registries. Continual improvement that aligns contemporary pattern of care essential. Objective To improve prognostic...
Poly(ADP-ribose) polymerase-1 (PARP1) has been reported to play an important role in longevity. Here, we showed that the knockdown of PARP1 extended lifespan Drosophila , with particular emphasis on skeletal muscle. The muscle-specific mutant exhibited resistance starvation and oxidative stress, as well increased ability climb, enhanced mitochondrial biogenesis activity at older age. Mechanistically, inhibition increases AMP-activated protein kinase alpha (AMPKα) turnover. could interact...
Inter-organ crosstalk has gained increasing attention in recent times; however, the underlying mechanisms remain unclear. In this study, we elucidate an endocrine pathway that is regulated by skeletal muscle interferon regulatory factor (IRF) 4, which manipulates liver pathology. Skeletal specific IRF4 knockout (F4MKO) mice exhibited ameliorated hepatic steatosis, inflammation, and fibrosis, without changes body weight, when put on a nonalcoholic steatohepatitis (NASH) diet. Proteomics...
Ferritin, the principal iron storage protein, is essential to homeostasis. How homeostasis affects adipose tissue not well understood. We investigated role of ferritin heavy chain in adipocytes energy metabolism. generated adipocyte-specific (Fth, also known as Fth1) knockout mice, herein referred FthAKO. These mice were analyzed for homeostasis, oxidative stress, mitochondrial biogenesis and activity, adaptive thermogenesis, insulin sensitivity, metabolic measurements. Mouse embryonic...
Objective Many female patients with nasopharyngeal carcinoma (NPC) desire to reproduce after treatment. To evaluate the outcomes of subsequent pregnancy NPC and explore prognostic effects in women.
In addition to the significant role in physical activity, skeletal muscle also contributes health through storage and use of macronutrients associated with energy homeostasis. However, mechanisms regulating integrated metabolism are not well-defined. Here, we compared transcriptome from obese lean control subjects different species (human mouse) found that interferon regulatory factor 4 (IRF4), an inflammation-immune transcription factor, conservatively increased subjects. Thus, investigated...
Obesity is an epidemic all around the world. Weight loss interventions that are effective differ from each other with regard to various lipidomic responses. Here, we aimed find biomarkers related beneficial changes in weight loss. We adopted untargeted liquid chromatography tandem mass spectrometry (LC-MS/MS) method measure 953 lipid species for Exercise (exercise intervention cohort, N = 25), 1388 LSG (laparoscopic sleeve gastrectomy 36), and 886 Cushing (surgical removal of ACTH-secreting...
Abstract Exercise‐induced fatigue and exhaustion are interesting areas for many researchers. Muscle glycogen is critical physical performance. However, how metabolism manipulated during exercise not very clear. The aim here to assess the impact of interferon regulatory factor 4 (IRF4) on skeletal muscle subsequent regulation capacity. Skeletal muscle‐specific IRF4 knockout mice show normal body weight insulin sensitivity, but better capacity increased content with unaltered triglyceride...
Myostatin (MSTN) has long been recognized as a critical regulator of muscle mass. Recently, there increasing interest in its role metabolism. In our study, we specifically knocked out MSTN brown adipose tissue (BAT) from mice (MSTNΔUCP1) and found that the gained more weight than did controls when fed high-fat diet, with progressive hepatosteatosis impaired skeletal activity. RNA-Seq analysis indicated signatures mitochondrial dysfunction inflammation MSTN-ablated BAT. Further studies...
Physical exercise is an important component of managing Alzheimer's disease (AD). miRNAs can be modulated by intervention.The study explored the involvement and potential mechanism miR-192-5p in protective effect physical on AD.Ninety AD patients were enrolled, which 45 cases accepted cycling training for continuous 3 months. The expression changes before after analyzed reverse transcription-quantitative PCR. 8-month-old APP/PS1 double Tg mice used as animal model. Mice voluntary (VE) group...
Hashimoto’s thyroiditis (HT) is an autoimmune disease, and its incidence continues to rise. Although scientists have studied this disease for many years discovered the potential effects of various proteins in it, specific pathogenesis still not fully comprehended. To understand HT translate knowledge clinical applications, we took mass spectrometric analysis on thyroid tissue fine-needle puncture from patients healthy people attempt make a further understanding HT. A total 44 with...
Abstract Background Lower motor neurons in the spinal cord lose supraspinal inputs after complete injury, leading to a loss of volitional control below injury site. Extensive locomotor training with stimulation can restore locomotion function humans and animals. However, this is non-voluntary, meaning that subjects cannot via their natural “intent” . A recent study demonstrated an advanced system triggers stimulator using forelimb stepping electromyographic patterns quadrupedal walking rats...
Background: The complex etiology of Ischemia-Reperfusion Injury (IRI) induced by liver transplantation (LT) and the “one-target-focused” method limit development effective therapeutic interventions. We aimed to reveal specific active ingredients mechanisms involved in Chinese herb Scutellaria baicalensis Georgi (SBG) alleviating IRI LT. Methods: potential macromolecular targets SBG were screened through related databases. differentially expressed genes LT obtained from GSE151648....
Hypoxic training has been reported to lower obesity morbidity without clear underlying mechanisms. This study investigates the effect of hypoxic on metabolic changes, particularly liver metabolism high fat diet (HFD)-induced obese mice. We compared group with normoxic sedentary, and sedentary groups. Body weight, mass, glucose tolerance physiology were determined after 4 weeks intervention. In both groups, body weight was than group, less mass. Insulin sensitivity improved training....
Purpose: To (i) describe the characteristics of physical fitness and cardiometabolic risk in Chinese university students with normal-weight obesity (NWO); (ii) assess association between NWO risk. Methods: A total 249 participants from 2018 Shanghai University Sport Alumni Health Cohort Study China formed study cohort. was defined as normal body mass index (17.9– 23.9 kg/m 2 for males; 17.2– females) but excess body-fat percentage (≥ 20% ≥ 30% females). Body composition assessed by...
The present study aimed to assess the changes in muscle strength and plasma metabolites athletes with β-glucan supplementation. A total of 29 who met inclusion criteria were recruited for this (ChiCTR2200058091) randomly divided into a placebo group (n = 14) 15). During trial, experimental received supplementation (2 g/d β-glucan) 4 weeks control an equal dose (0 β-glucan), both groups maintaining their regular diet exercise habits during trial. athletes’ performance, strength, metabolome...
Abstract Poly(ADP‐ribose) polymerase 1 (PARP1) plays a key role in genome stability by modulating DNA‐damage responses. Activated DNA interruptions through ultraviolet (UV) exposure, PARylation is synthesized PARP1 and serves as survival mechanism for cancer metabolic diseases. Several strategies including ROS antimicrobial peptides (AMPs) function host defenses, while the targeted tissue under damage are unknown. Here, we show that induces responses specifically gut tissue. The knockdown of...