A5103122739- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Salivary Gland Tumors Diagnosis and Treatment
- Oral health in cancer treatment
- Brain Metastases and Treatment
- Esophageal Cancer Research and Treatment
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Esophageal and GI Pathology
- Lymphoma Diagnosis and Treatment
- Dysphagia Assessment and Management
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Ear and Head Tumors
- Medical Imaging Techniques and Applications
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Chronic Lymphocytic Leukemia Research
- Radiomics and Machine Learning in Medical Imaging
- CNS Lymphoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Oral and Maxillofacial Pathology
- Maternal and fetal healthcare
- Pregnancy and Medication Impact
University of Chinese Academy of Sciences
2020-2025
Zhejiang Cancer Hospital
2015-2025
Nanjing Medical University
2024-2025
Jiangsu Province Hospital
2024-2025
Translational Research in Oncology
2023
Chinese Academy of Sciences
2020-2023
Cancer Hospital of Chinese Academy of Medical Sciences
2020-2022
Peking Union Medical College Hospital
2016
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2016
Academy of Medical Sciences
2015
Importance Accurate staging is a fundamental step in treating patients with nasopharyngeal carcinoma (NPC) worldwide; this crucial not only for prognostication, but also guiding treatment decisions. The American Joint Committee on Cancer (AJCC)/Union International Control (UICC) tumor-node-metastasis (TNM) system the global language clinicians, researchers, and cancer registries. Continual improvement that aligns contemporary pattern of care essential. Objective To improve prognostic...
Abstract Background LncRNAs are engaged in signaling pathways human physiological and pathological states. However, mediate the onset of labor still remains unknown. Methods RNA sequencing lower segment myometrium (in vs. not labor) was analyzed. N6-Methyladenosine (m6A) complexes were detected by RIP meRIP myometrial cells. Plasmid siRNA transfection performed, contraction ability assessed. pulldown, silver staining, protein mass spectrometry used to identify binding proteins. FISH...
The role of contemporary radiotherapy (RT) has not yet been elucidated, mainly because the low incidence cervical esophageal cancer. purpose this study was to analyze outcome in patients with cancer treated definitive RT.A total 115 RT during January 2001 through April 2012 our center were analyzed. Eighty received alone and 35 concurrent chemoradiotherapy cisplatin administered either weekly (30 mg/m2) or every 3 weeks (80 mg/m2).The median follow-up time 17.1 months. For all patients,...
Purpose: To explore the efficacy of concomitant chemotherapy in intensity-modulated radiotherapy(IMRT) to treat stage II nasopharyngeal carcinoma (NPC). Methods and Materials: In this randomized phase 2 study (registered with ClinicalTrials.gov, (NCT01187238)), eligible patients (2010 UICC/AJCC) NPC were randomly assigned either IMRT alone (RT group) or combined concurrent cisplatin (40 mg/m2, weekly) (CCRT group). The primary endpoint was overall survival (OS). second endpoints included...
The aim of this study is to explore how quercetin interacts with pancreatic cancer stem-like cells and the mechanism underlying effective quercetin-mediated suppression.A model was generated by using a sphere formation culture system. A comparative analysis performed between parent related treatment strategy focusing on stem cell (CSC) properties drug-resistance-related mechanisms in vitro.Our data show that have greater resistance gemcitabine stronger CSC compared cells. In contrast cells,...
The aim of the present study was to evaluate prognostic value magnetic resonance imaging (MRI)‒determined lymph nodal necrosis (LNN) in nasopharyngeal carcinoma (NPC) and explore feasibility an N-classification system based on 8th edition American Joint Committee Cancer (AJCC) system.The MRI scans 616 patients with newly diagnosed stage T1-4N1-3M0 NPC who were treated definitive intensity-modulated radiotherapy (IMRT) reviewed.Multivariate analysis showed that LNN independent negative...
Malnutrition is a concern in patients with nasopharyngeal carcinoma (NPC) during chemoradiotherapy (CRT)/radiotherapy (RT), which considered to be related radiation-induced oral mucositis (ROM). The study aimed evaluate the nutritional status of NPC RT and investigate its association ROM.A prospective was conducted patients. Patients were divided into three subgroups (mild, moderate, severe groups) based on duration ROM (≥ grade 3). Body weight, body mass index (BMI), albumin, prealbumin,...
The aim of the present study was to summarize clinical characteristics primary breast lymphoma (PBL) and evaluate its management approaches. A total 29 patients newly diagnosed with PBL, treated between April 2006 May 2013, were analyzed retrospectively. median survival follow-up time for all 66.8 (range, 25.4-110.0) months. results revealed 22 living lymphoma-free 7 who had succumbed PBL. Of deceased patients, 6 1 chemotherapy-associated hepatic failure. In total, patient presented...
Background and objective: The aim of this study was to evaluate the expression cytomembranic programmed death-ligand 1 (PD-L1) its clinical significance in locoregionally advanced nasopharyngeal carcinoma (NPC). Patients methods: Formalin-fixed, paraffin-embedded tissue biopsies from 85 patients with histological diagnosis NPC treated radical intensity-modulated radiotherapy concurrent cisplatin-based chemotherapy were studied. By using immunohistochemistry staining, expressions PD-L1 on...
Although parotid-sparing IMRT decreased the dose distribution of parotid, parotid region recurrence has been reported. Prophylactic irradiation in area would be necessary patients with high risk lymph node metastasis (PLNM). This study was to detect high-risk factors PLNM nasopharyngeal carcinoma. a 1:2 case-control study. All this were newly diagnosed NPC N2-3 classification from January 2005 December 2012. Cases 22 sides ipsilateral PLNM. Controls 44 who randomly selected disease database....
Objective To evaluate concurrent chemotherapy for T4 classification nasopharyngeal carcinoma (NPC) treated by intensity-modulated radiotherapy (IMRT). Methods From July 2004 to June 2011, 180 non-metastatic NPC patients were retrospectively analyzed. Of these patients, 117 chemoradiotherapy (CCRT) using IMRT and 63 cases alone. Results The median follow-up time was 58.97 months (range, 2.79–114.92) months. For all the 1, 3 5-year local failure-free survival (LFFS) rates 97.7%, 89.2% 85.9%,...
We explored the influence of body mass index (BMI) on long-term outcomes in patients with esophageal squamous cell carcinoma (ESCC) who underwent esophagectomy as a primary treatment. BMI is risk factor for development cancer. However, details relationship between and cancer prognosis remains unclear. Patients an initial treatment 2000 to 2009 period were included. The divided into 3 groups according Asian-specific cut-offs. associations explored. This study included 1082 ESCC 2009; all...
This study was conducted is to identify the prognostic value and staging categories of magnetic resonance imaging (MRI)-detected intracranial extension in nasopharyngeal carcinoma (NPC) with intensity-modulated radiotherapy (IMRT) determine whether it necessary subclassify T4 classification NPC.A total 335 nonmetastatic NPC patients MRI treated between March 2004 June 2011 by radical IMRT were included. The subclassified into two grades (T4a, without vs. T4b, extension) according site...
Abstract Background To evaluate the expression of programmed death‐1 (PD‐1) and death‐ligand 1 (PD‐L1) by using immunohistochemistry analysis in locoregionally advanced nasopharyngeal carcinoma (NPC) patients receiving cisplatin, fluorouracil, docetaxel followed concurrent chemoradiotherapy. Methods As part a previously reported trial, 108 were enrolled this study. Results We observed that Epstein–Barr Virus (EBV) antibody levels associated with PD‐1 positive staining NPC was identified as...
The aim of this study is to evaluate the prognostic value grading MRI-detected skull-base invasion in nasopharyngeal carcinoma (NPC) with after intensity-modulated radiotherapy (IMRT).This a retrospective chart review 469 non-metastatic NPC patients invasion. Patients were classified as extensive (ESBI) group and limited (LSBI) group.Multivariate analysis showed that (LSBI vs. ESBI) was an independent predictor progression free survival (PFS). estimated 5-year local failure (LFFS), distant...