A5083645513- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- interferon and immune responses
- Muscle activation and electromyography studies
- Thyroid Disorders and Treatments
- Advanced Proteomics Techniques and Applications
- RNA modifications and cancer
- Muscle Physiology and Disorders
- Parkinson's Disease Mechanisms and Treatments
- PARP inhibition in cancer therapy
- Metabolomics and Mass Spectrometry Studies
- Genetics, Aging, and Longevity in Model Organisms
- Telomeres, Telomerase, and Senescence
- Thyroid Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
Fudan University
2021-2023
State Key Laboratory of Genetic Engineering
2023
Zhongshan Hospital
2021
Poly(ADP-ribose) polymerase-1 (PARP1) has been reported to play an important role in longevity. Here, we showed that the knockdown of PARP1 extended lifespan Drosophila , with particular emphasis on skeletal muscle. The muscle-specific mutant exhibited resistance starvation and oxidative stress, as well increased ability climb, enhanced mitochondrial biogenesis activity at older age. Mechanistically, inhibition increases AMP-activated protein kinase alpha (AMPKα) turnover. could interact...
In addition to the significant role in physical activity, skeletal muscle also contributes health through storage and use of macronutrients associated with energy homeostasis. However, mechanisms regulating integrated metabolism are not well-defined. Here, we compared transcriptome from obese lean control subjects different species (human mouse) found that interferon regulatory factor 4 (IRF4), an inflammation-immune transcription factor, conservatively increased subjects. Thus, investigated...
DJ-1 is a causative gene for Parkinson's disease. DJ-1-deficient mice develop gait-associated progressive behavioural abnormalities and hypoactive forearm grip strength. However, underlying activity mechanisms are not fully explored.Western blotting quantitative real-time polymerase chain reaction approaches were adopted to analyse expression in skeletal muscle from aged humans or compared with young subjects. Skeletal muscle-specific-DJ-1 knockout (MDKO) generated, followed by an assessment...
Hashimoto’s thyroiditis (HT) is an autoimmune disease, and its incidence continues to rise. Although scientists have studied this disease for many years discovered the potential effects of various proteins in it, specific pathogenesis still not fully comprehended. To understand HT translate knowledge clinical applications, we took mass spectrometric analysis on thyroid tissue fine-needle puncture from patients healthy people attempt make a further understanding HT. A total 44 with...
<p> </p> <p>In addition to the significant role in physical activity, skeletal muscle also contributes health through storage and use of macronutrients associated with energy homeostasis. However, mechanisms regulating integrated metabolism were not well-defined. Here, we compared transcriptome from obese lean controls different species (human mouse), found that interferon regulatory factor 4 (IRF4), an inflammation-immune transcription factor, conservatively increased...
<p> </p> <p>In addition to the significant role in physical activity, skeletal muscle also contributes health through storage and use of macronutrients associated with energy homeostasis. However, mechanisms regulating integrated metabolism were not well-defined. Here, we compared transcriptome from obese lean controls different species (human mouse), found that interferon regulatory factor 4 (IRF4), an inflammation-immune transcription factor, conservatively increased...