A5038128649- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- MicroRNA in disease regulation
- Bioinformatics and Genomic Networks
- Microplastics and Plastic Pollution
- Glioma Diagnosis and Treatment
- Wastewater Treatment and Nitrogen Removal
- Recycling and Waste Management Techniques
- Chromosomal and Genetic Variations
- CRISPR and Genetic Engineering
- Gene expression and cancer classification
- Liver Disease Diagnosis and Treatment
- Conducting polymers and applications
- Genomics and Phylogenetic Studies
- Ferroptosis and cancer prognosis
- Advanced Sensor and Energy Harvesting Materials
- Circular RNAs in diseases
- Microbial Fuel Cells and Bioremediation
- Cancer, Hypoxia, and Metabolism
- Membrane Separation Technologies
- interferon and immune responses
- Adipose Tissue and Metabolism
Zhejiang Gongshang University
2024-2025
The First Affiliated Hospital, Sun Yat-sen University
2024
Zhongshan Hospital
2021-2024
Fudan University
2007-2024
Sun Yat-sen University
2024
University of Chinese Academy of Sciences
2005-2024
Army Medical University
2014-2024
First Affiliated Hospital of Hebei Medical University
2024
Hebei Medical University
2024
Beijing Jiaotong University
2024
Abstract The behavior of transcriptomes and epigenomes in hybrids heterotic parents is fundamental interest. Here, we report highly integrated maps the epigenome, mRNA, small RNA two rice (Oryza sativa) subspecies their reciprocal hybrids. We found that gene activity was correlated with DNA methylation both active repressive histone modifications transcribed regions. Differential epigenetic changes transcript levels among parental lines. Distinct patterns expression were observed. Through...
Abstract Background Small noncoding RNAs (ncRNAs), including short interfering (siRNAs) and microRNAs (miRNAs), can silence genes at the transcriptional, post-transcriptional or translational level [1, 2]. Results Here, we show that microRNA-10a (miR-10a) targets a homologous DNA region in promoter of hoxd4 gene represses its expression transcriptional level. Mutational analysis miR-10a sequence revealed 3' end miRNA is most critical element for silencing effect. MicroRNA-10a-induced...
Recent advances in transcriptome sequencing have enabled the discovery of thousands long non-coding RNAs (lncRNAs) across many species. Though several lncRNAs been shown to play important roles diverse biological processes, functions and mechanisms most remain unknown. Two significant obstacles lie between functional characterization lncRNAs: identifying truly genes from de novo reconstructed transcriptomes, prioritizing hundreds resulting putative for downstream experimental...
Abstract The development of the Internet Things (IoT) indicates that humankind has entered a new intelligent era “Internet Everything”. Thanks to characteristics low‐cost, diverse structure, and high energy conversion efficiency, self‐powered sensing systems, which are based on Triboelectric Nanogenerator (TENG), demonstrate great potential in field IoT. In order solve challenges TENG signal processing, such as noise nonlinear relations, Machine Learning (ML), is an efficient mature data...
A novel normalization method based on the GC content of probes is developed for two-color tiling arrays. The proposed method, together with robust estimates model parameters, shown to perform superbly published data sets. algorithm detecting peak regions also formulated and well compared other approaches. tools have been implemented as a stand-alone Java program called MA2C, which can display various plots statistical analysis quality control.
Background Piwi-interacting RNA (piRNA) is the largest class of small non-coding molecules. The transposon-derived piRNA prediction can enrich research contents ncRNAs as well help to further understand generation mechanism gamete. Methods In this paper, we attempt differentiate piRNAs from non-piRNAs based on their sequential and physicochemical features by using machine learning methods. We explore six sequence-derived features, i.e. spectrum profile, mismatch subsequence position-specific...
Abstract Topologically associating domains (TADs) are critical structural units in three-dimensional genome organization of mammalian genome. Dynamic reorganizations TADs between health and disease states associated with essential functions. However, computational methods for identifying reorganized still the early stages development. Here, we present DiffDomain, an algorithm leveraging high-dimensional random matrix theory to identify structurally using high-throughput chromosome...
Recent evidence points to considerable transcription occurring in non-protein-coding regions of eukaryote genomes. However, their lack conservation and demonstrated function have created controversy over whether these transcripts are functional. Applying a novel cloning strategy, we cloned 100 61 known or predicted Caenorhabditis elegans full-length ncRNAs. Studying the genomic environment transcriptional characteristics shown that two-thirds all ncRNAs, including many intronic snoRNAs,...
Abstract Background Recent analysis of the mouse transcriptional data has revealed existence ~34,000 messenger-like non-coding RNAs (ml-ncRNAs). Whereas functional properties these ml-ncRNAs are beginning to be unravelled, no information is available for large majority transcripts. Results A few ml-ncRNA have been shown genomic loci that overlap with microRNA loci, leading us suspect a fraction may encode microRNAs. We therefore developed an algorithm (PriMir) specifically detecting...
Abstract A novel biomimetic mineralization system was designed to induce a layer of hydroxyapatite on demineralized dentin surface. This constructed as follows. 0.5% agarose gel containing 0.26 M Na 2 HPO 4 used cover acid‐etched slices, followed by without phosphate ions. Then neutral 0.13 CaCl solution added onto the ion‐free The (dentin‐agarose ions‐CaCl solution) kept in water bath at 37°C, and were replaced various intervals. results showed that deposited crystals densely packed each...
In recent years, ultrasound has emerged as a widely used technology for modifying proteins/peptides. this study, we focused on the intrinsic mechanism of ultrasound-induced modification bovine liver peptides, which were treated with power 0, 100, 200, 300, 400, and 500 W, their physicochemical functional properties, well ultrastructures, investigated. The results show that mainly affects hydrogen bonding hydrophobic interactions to change conformation proteins unfolds through cavitation...