A5060886818- Plant Molecular Biology Research
- Light effects on plants
- Photosynthetic Processes and Mechanisms
- Greenhouse Technology and Climate Control
- Circadian rhythm and melatonin
- Telomeres, Telomerase, and Senescence
- PARP inhibition in cancer therapy
- Genetics, Aging, and Longevity in Model Organisms
- Sleep and Wakefulness Research
- Regulation of Appetite and Obesity
- Dietary Effects on Health
- Neuropeptides and Animal Physiology
- Cancer-related molecular mechanisms research
- Thyroid Cancer Diagnosis and Treatment
- Advanced Proteomics Techniques and Applications
- Thyroid Disorders and Treatments
Fudan University
2017-2024
Zhongshan Hospital
2021
State Key Laboratory of Genetic Engineering
2020
Poly(ADP-ribose) polymerase-1 (PARP1) has been reported to play an important role in longevity. Here, we showed that the knockdown of PARP1 extended lifespan Drosophila , with particular emphasis on skeletal muscle. The muscle-specific mutant exhibited resistance starvation and oxidative stress, as well increased ability climb, enhanced mitochondrial biogenesis activity at older age. Mechanistically, inhibition increases AMP-activated protein kinase alpha (AMPKα) turnover. could interact...
Light filtered through dense planting initiates the shade avoidance syndrome (SAS) in plants, which helps them compete against their neighbors. Quantitative trait loci (QTL)-based analysis identified nighttime-expressed clock component ELF3 as a new player SAS, but its detailed mechanism is unclear. Here, we show that circadian gates shade-induced gene expression and hypocotyl elongation at night. involved nighttime suppression via interaction with inactivation of PHYTOCHROME-INTERACTING...
Photomorphogenesis is a critical developmental process bridging light-regulated transcriptional reprogramming with morphological changes in organisms. Strikingly, the chromatin-based control of photomorphogenesis remains poorly understood. Here, we show that Arabidopsis (Arabidopsis thaliana) ortholog ATP-dependent chromatin-remodeling factor AtINO80 represses plant photomorphogenesis. Loss inhibited hypocotyl cell elongation and caused anthocyanin accumulation. Both light-induced genes...
Hashimoto’s thyroiditis (HT) is an autoimmune disease, and its incidence continues to rise. Although scientists have studied this disease for many years discovered the potential effects of various proteins in it, specific pathogenesis still not fully comprehended. To understand HT translate knowledge clinical applications, we took mass spectrometric analysis on thyroid tissue fine-needle puncture from patients healthy people attempt make a further understanding HT. A total 44 with...
Resistance to stress is a key determinant for mammalian functioning. While many studies have revealed neural circuits and substrates responsible initiating mediating responses, little known about how the brain resists prevents overreactions. Here, we identified previously uncharacterized neuropeptide Y (NPY) neuronal population in dorsal raphe nucleus ventrolateral periaqueductal gray region (DRN/vlPAG) with anxiolytic effects male mice. NPYDRN/vlPAG neurons are rapidly activated by various...