A5061568176- Adipose Tissue and Metabolism
- Luminescence and Fluorescent Materials
- Adipokines, Inflammation, and Metabolic Diseases
- Schizophrenia research and treatment
- Quantum Dots Synthesis And Properties
- Myasthenia Gravis and Thymoma
- Treatment of Major Depression
- Cardiovascular Disease and Adiposity
- Conducting polymers and applications
- Nanocluster Synthesis and Applications
- Angiogenesis and VEGF in Cancer
- Polymer Nanocomposites and Properties
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Molecular Sensors and Ion Detection
- Diet and metabolism studies
- Cancer, Hypoxia, and Metabolism
- Synthesis and properties of polymers
- Silicone and Siloxane Chemistry
- Circular RNAs in diseases
- Functional Brain Connectivity Studies
- Carbon and Quantum Dots Applications
- Peripheral Neuropathies and Disorders
- Liver Disease Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
First Affiliated Hospital of Jinan University
2021-2025
Jilin Province Tumor Hospital
2019-2024
Changchun Normal University
2020-2024
Changchun University of Chinese Medicine
2019-2024
Second Affiliated Hospital of Zhejiang University
2024
Northeast Normal University
2008-2023
Southern Medical University
2015-2023
Zhejiang Sci-Tech University
2022
People 's Hospital of Jilin Province
2016-2022
Air Force Medical University
2020-2022
Beige adipocytes are an inducible form of mitochondria-enriched thermogenic that emerge in response to external stimuli, such as chronic cold exposure. We have previously shown after the withdrawal beige directly acquire a white fat-like phenotype through autophagy-mediated mitochondrial degradation. investigated upstream pathway mediates clearance and report Parkin-mediated mitophagy plays key role beige-to-white adipocyte transition. Mice genetically deficient Park2 showed reduced...
An aggregation-induced emission based sensor that detects CN<sup>−</sup>, SO<sub>3</sub><sup>2−</sup>and Fe<sup>3+</sup>in aqueous solution and can be applied in test strips cellular imaging was designed.
In experimental stroke research, anesthesia is common and serves as a major reason for translational failure. Real-time cerebral blood flow (CBF) monitoring during onset can provide important information the prediction of brain injury; however, this difficult to achieve in clinical practice due various technical problems. We created photothrombotic focal ischemic model utilizing our self-developed miniature headstage conscious freely moving rats. model, high spatiotemporal resolution imager...
Abstract A series of novel nano‐ZnO/polymer composite films with different ZnO contents was prepared through incorporation pre‐made colloidal particles into monomer mixtures urethane‐methacrylate oligomer and 2‐hydroxyethyl methacrylate, followed by ultraviolet (UV) radiation‐initiated polymerization. The nanoparticles a diameter 3–5 nm were synthesized from zinc acetate lithium hydroxide in ethanol via wet chemical method. In order to stabilize immobilize the polymer matrix, further capped...
Adipose tissues are classified into white adipose tissue (WAT) and brown (BAT). WAT is responsible for energy storage, malfunction associated with obesity. BAT, on the contrary, consumes fat to generate heat through uncoupling mitochondrial respiration important in body weight control. Vascular endothelial growth factor (VEGF)-A founding member of VEGF family has been found highly expressed tissue. A genetic mouse model an inducible (VEGF-A) repression system was used study VEGF-regulated...
Background: Thyroid cancer, the most common endocrine neoplasia, has seen a rapid increase in global incidence, with USA reporting over 62,000 new cases 2015, making it fifth cancer among women. Differentiated thyroid accounts for more than 95% of and arises from follicular epithelial cells, primarily manifesting as papillary (PTC) (FTC). Despite significant advancements understanding molecular mechanisms underlying these cancers, identification relevant genes comprehensive view...
White light emitting semiconductor nanocrystals (NCs) have been successfully synthesized from 8-hydroxyquinoline-5-sulfonic acid (HQS) decorated manganese doped ZnS NCs through fine tuning the surface-coordination emission and dopant of NC host. The HQS functionalized (QS-ZnS:Mn), with a cubic crystal structure, same diameter about 4.0 nm as ZnS:Mn without HQS. intensity peak increased increasing content or augmenting excited wavelength. white was achieved by carefully controlling dosage in...
Obesity is the result of abnormal adipose development and energy metabolism. Using vascular endothelial growth factor (VEGF) B–knockout inducible VEGF downregulation mouse models, we have shown that VEGFB inactivation caused expansion white adipose, whitening brown an increase in fat accumulation, a reduction consumption. At same time, expression adipose–associated genes was increased decreased. repression, contrast, induced adipocyte expenditure, upregulated genes, downregulated genes. When...
Nitroxides have great potential as magnetic resonance imaging (MRI) contrast agents for tumor detection. Polyacetylenes(PAs) containing 2,2,6,6‐tetramethyl‐piperidine oxyl (TEMPO) and poly(ethylene glycol) were synthesized via metathesis polymerization of the corresponding substituted acetylenes to be used targeted bimodal MRI /optical tumors. The in polyacetylenes enables covalent conjugation carboxyl fluorescein folic acid (FA) with hydroxyl groups develop multifunctional organic radical...
Soluble epoxide hydrolase (sEH) catalyzes the conversion of epoxyeicosatrienoic acids into less active eicosanoids, and inhibitors sEH have anti-inflammatory antiapoptotic properties. Based on previous observations that inhibition attenuates cisplatin-induced nephrotoxicity by modulating nuclear factor-<i>κ</i>B signaling, we hypothesized this strategy would also attenuate renal apoptosis. Inhibition with AR9273 [1-adamantan-1-yl-3-(1-methylsulfonyl-piperidin-4-yl-urea)] reduced apoptosis...
Optical/MRI bimodal probes have attracted much attention due to palmary soft tissue resolution and high imaging sensitivity. In this study, poly[fluorene-co-alt-p-phenylene] containing organic radical (PFP-TEMPO+) is successfully developed for optical MRI dual-modality bioimaging. PFP-TEMPO+ displays advanced properties such as fluorescence emission, photostablilty, reasonable T1 relaxation effect, low cytotoxicity, good biocompatibility. Moreover, the ability of tumor tissues confirms that...
Background This study aims to develop and validate a nomogram for predicting 1- 2-year generalization probabilities in patients with ocular myasthenia gravis (OMG). Methods In total, 501 eligible OMG treated at seven tertiary hospitals China between January 2015 May 2019 were included. The primary outcome measure was disease generalization. A constructed using stepwise Cox regression model. Nomogram performance quantified C-indexes calibration curves. Two-year cumulative rates analyzed the...