A5022826141- Nanoplatforms for cancer theranostics
- Liver Disease Diagnosis and Treatment
- Photodynamic Therapy Research Studies
- Gut microbiota and health
- Luminescence and Fluorescent Materials
- Chronic Obstructive Pulmonary Disease (COPD) Research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Helicobacter pylori-related gastroenterology studies
- Traditional Chinese Medicine Studies
- Pharmacological Effects of Natural Compounds
- Ferroptosis and cancer prognosis
- Drug Transport and Resistance Mechanisms
- Molecular Sensors and Ion Detection
- Gestational Diabetes Research and Management
- Extracellular vesicles in disease
- Liver physiology and pathology
- Medical Research and Treatments
- Photoacoustic and Ultrasonic Imaging
- Advanced Nanomaterials in Catalysis
- Traditional Chinese Medicine Analysis
- Diet and metabolism studies
- Probiotics and Fermented Foods
- Neurological Disease Mechanisms and Treatments
- Sulfur Compounds in Biology
South China University of Technology
2024
Ningbo University
2018-2024
Beijing Sport University
2024
Jiyang College of Zhejiang A&F University
2024
Ningbo First Hospital
2023
Southern Medical University
2016-2022
Shuguang Hospital
2016-2022
Shanghai University of Traditional Chinese Medicine
2016-2022
The First Affiliated Hospital, Sun Yat-sen University
2022
Sun Yat-sen University
2022
Pre-eclampsia (PE) is the most common complication of pregnancy and seriously threatens health safety mother child. Studies have shown that an imbalance in gut microbiota can affect progression PE. Trimethylamine N-oxide (TMAO) intestinal microbiota-derived metabolite thought to be involved occurrence PE; however, its causal relationship mechanism remain unclear. In this clinical cohort study, including 28 patients with eclampsia 39 matched healthy controls, fecal samples were collected for...
Abstract Pancreatic ductal adenocarcinoma (PDAC) presents a formidable global health challenge. Targeting genetic aberrations, particularly KRAS and TP53 mutations, remains critical challenge in PDAC treatment. Herein, it is demonstrated for the first time that electron‐rich aromatic pyrrole derivatives can be transformed into red‐to‐near‐infrared emissive radical cations an acidic buffer, efficiently targeting mitochondria triggering mutant p53 (mutp53) degradation. Leveraging positive...
Green-emitting carbon dots (G-CDs) were synthesized <italic>via</italic> a simple and green hydrothermal method using betaine hydrochloride sulfadiazine as nitrogen sources, respectively.
The change in the characteristics of gut microbiota is linked to gestational diabetes mellitus (GDM). However, whether and how microbiota-derived metabolites GDM uncertain. Here, we aimed determine associations between GDM.
Objective To investigate the expression of short-chain fatty acids (SCFAs)—metabolites intestinal flora—in gestational complications diabetes mellitus (GDM), preeclampsia (PE), and intrahepatic cholestasis pregnancy (ICP), its clinical significance. Methods Targeted metabonomics was used to detect SCFAs in serum 28 GDM pregnant women, PE 29 ICP 27 healthy women (NP); their changes were observed; correlation between characteristics studied; potential as biomarkers for diagnosis evaluated....
Abstract Drug resistance is one of the leading causes treatment failure in current cancer chemotherapy. In addition to classical drug efflux transporter‐mediated chemoresistance, cells with stemness features play a crucial role escaping maximum impact To sensitize chemotherapy, novel approach, hedgehog pathway inhibitor ellagic acid (EA) coordinated Cu 2+ develop nanoscale metal–organic frameworks (EA‐Cu), which are then loaded doxorubicin (DOX) and modified targeted chondroitin sulfate (CS)...
Astragaloside IV (AS-IV) is one of the main pharmacologically active compounds found in Astragalus membranaceus. AS-IV has protective effects against ischemia-reperfusion injury (IRI), but its mechanism action not yet been determined. This study aims to investigate effect on IRI and phosphadylinositol 3-kinase (PI3K)/Akt/heme oxygenase (HO-1) signaling pathway through vitro experiments. Firstly, a cell culture model myocardiocyte hypoxia-reoxygenation (H/R) was replicated. After treatment,...
EPA, superior to DHA, significantly attenuated DSS-induced colitis involved in promoting the expression of tight junction proteins, suppressing inflammatory signaling pathways and triggering intestinal epithelial cell proliferation.
Abstract Acetaminophen (APAP)-induced liver injury (AILI) is the most frequent cause of acute failure; but underlying mechanisms still remain obscure. Macrophages and endoplasmic reticulum (ER) stress play an important role in pathogenesis AILI. Mesencephalic astrocyte-derived neurotrophic factor (MANF) a newly identified 18-kDa soluble protein, whose expression secretion are stimulated by ER stress. To investigate myeloid cell MANF AILI, we assayed serum samples from AILI model mice...
Background: Ulcerative colitis (UC) is a chronic inflammatory disorder of the colon with continuously remitting and relapsing course. Its etiology closely related to abnormal interactions between host gut microbiota. The mucus barrier lining gastrointestinal tract necessary coordinate microbiota interaction by nourishing modulating Differential effects anti-inflammatory fatty acids docosahexaenoic acid (DHA) eicosapentaenoic (EPA) on UC progression in mice were firstly addressed our previous...
Nonalcoholic fatty liver disease (NAFLD) has developed into the most common chronic and can lead to cancer. Our laboratory previously a novel prescription for NAFLD, "Eight Zhes Decoction" (EZD), which shown good curative effects in clinical practice. However, pharmacodynamic material basis mechanism have not yet been revealed. A strategy integrating lipidomics, network pharmacology pharmacokinetics was used reveal active components mechanisms of EZD against NAFLD. The histopathological...
To measure the expression profile of circular RNA (circRNA) in hepatic tissues a liver fibrosis model and to explore their function using molecular biology bioinformatic techniques.The classic CCl4 mouse was established alongside normal control group. The circRNA tissue from two groups compared high-throughput microarray. differentially expressed circRNAs were identified, real-time quantitative polymerase chain reaction (RT-qPCR) used verify subset (target genes). At same time, oxidative...
Preeclampsia (PE) is a complex pregnancy-related hypertensive disorder leading to multiorgan dysfunction. It has high maternal, fetal, and neonatal morbidity mortality rates. The study of gut microbiota its metabolites in PE deserves further exploration. Thirty-eight pregnant women with 29 healthy the third trimester their pregnancy were recruited this study. We used targeted metabolomics approach evaluate short-chain fatty acids (SCFAs) serum samples. correlation between SCFAs clinical...